Formation of Bone-like Nanocrystalline Apatite Using Self-Assembled Liquid Crystals
(2012) In Chemistry of Materials 24(5). p.892-902- Abstract
- A two-step process using liquid crystalline phases combined with controlled postcrystallization for the preparation of bone-like apatite has been developed. First, amorphous calcium phosphate (ACP) spherules with a diameter of 10.8 +/- 1.4 nm and specific surface area (SSA) in the range of 150-170 m(2)/g were synthesized within a reverse hexagonal liquid crystalline (LC) phase. Second, the ACP spherules were dispersed and aged in Milli-Qwater, where they crystallized into poorly crystalline apatite (PCA). The addition of heparin during aging was explored, which was shown to retard the ACP - PCA conversion. The particle formation within the LC phase was monitored using synchrotron small-angle X-ray scattering, and the formed materials were... (More)
- A two-step process using liquid crystalline phases combined with controlled postcrystallization for the preparation of bone-like apatite has been developed. First, amorphous calcium phosphate (ACP) spherules with a diameter of 10.8 +/- 1.4 nm and specific surface area (SSA) in the range of 150-170 m(2)/g were synthesized within a reverse hexagonal liquid crystalline (LC) phase. Second, the ACP spherules were dispersed and aged in Milli-Qwater, where they crystallized into poorly crystalline apatite (PCA). The addition of heparin during aging was explored, which was shown to retard the ACP - PCA conversion. The particle formation within the LC phase was monitored using synchrotron small-angle X-ray scattering, and the formed materials were characterized by X-ray diffraction, conventional and high-resolution transmission electron microscopy, nitrogen adsorption, thermogravimetry with infrared-coupled analysis, and Raman spectroscopy. The PCA formed using the LC aging route presented bone-resembling features, such as,Ca2+ and OH- deficiency, CO32- substitution, poor crystallinity; and ultrahigh SSA of 356 m(2)/g. The resulting particles were compared to hydroxyapatite synthesized via a conventional water-based precipitation method. The LC-aging route exhibited excellent controllability over the CaP crystallization, which enabled facile tailoring of the resulting material properties for different types of application. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2515532
- author
- He, Wenxiao ; Kjellin, Per ; Currie, Fredrik ; Handa, Paul ; Knee, Christopher S. ; Bielecki, Johan ; Wallenberg, Reine LU and Andersson, Martin
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- liquid crystalline phase, nanoparticles, calcium, phosphate, apatite, bone
- in
- Chemistry of Materials
- volume
- 24
- issue
- 5
- pages
- 892 - 902
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- wos:000301398100015
- scopus:84858233138
- ISSN
- 0897-4756
- DOI
- 10.1021/cm201077t
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Polymer and Materials Chemistry (LTH) (011001041)
- id
- 873ec1ca-f7c6-4c75-8b21-1a6f3f571d2d (old id 2515532)
- date added to LUP
- 2016-04-01 10:22:20
- date last changed
- 2023-11-09 19:16:03
@article{873ec1ca-f7c6-4c75-8b21-1a6f3f571d2d,
abstract = {{A two-step process using liquid crystalline phases combined with controlled postcrystallization for the preparation of bone-like apatite has been developed. First, amorphous calcium phosphate (ACP) spherules with a diameter of 10.8 +/- 1.4 nm and specific surface area (SSA) in the range of 150-170 m(2)/g were synthesized within a reverse hexagonal liquid crystalline (LC) phase. Second, the ACP spherules were dispersed and aged in Milli-Qwater, where they crystallized into poorly crystalline apatite (PCA). The addition of heparin during aging was explored, which was shown to retard the ACP - PCA conversion. The particle formation within the LC phase was monitored using synchrotron small-angle X-ray scattering, and the formed materials were characterized by X-ray diffraction, conventional and high-resolution transmission electron microscopy, nitrogen adsorption, thermogravimetry with infrared-coupled analysis, and Raman spectroscopy. The PCA formed using the LC aging route presented bone-resembling features, such as,Ca2+ and OH- deficiency, CO32- substitution, poor crystallinity; and ultrahigh SSA of 356 m(2)/g. The resulting particles were compared to hydroxyapatite synthesized via a conventional water-based precipitation method. The LC-aging route exhibited excellent controllability over the CaP crystallization, which enabled facile tailoring of the resulting material properties for different types of application.}},
author = {{He, Wenxiao and Kjellin, Per and Currie, Fredrik and Handa, Paul and Knee, Christopher S. and Bielecki, Johan and Wallenberg, Reine and Andersson, Martin}},
issn = {{0897-4756}},
keywords = {{liquid crystalline phase; nanoparticles; calcium; phosphate; apatite; bone}},
language = {{eng}},
number = {{5}},
pages = {{892--902}},
publisher = {{The American Chemical Society (ACS)}},
series = {{Chemistry of Materials}},
title = {{Formation of Bone-like Nanocrystalline Apatite Using Self-Assembled Liquid Crystals}},
url = {{http://dx.doi.org/10.1021/cm201077t}},
doi = {{10.1021/cm201077t}},
volume = {{24}},
year = {{2012}},
}