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Screening of organic solvents for bioprocesses using aqueous-organic two-phase systems

Rosinha Grundtvig, Inês P. ; Heintz, Søren ; Krühne, Ulrich ; Gernaey, Krist V. ; Adlercreutz, Patrick LU orcid ; Hayler, John D. ; Wells, Andy S. and Woodley, John M. (2018) In Biotechnology Advances 36(7). p.1801-1814
Abstract

The application of conventional organic solvents has been essential in several steps of bioprocesses in order to achieve sufficient economic efficiency. The use of organic solvents is frequently used either to partly or fully replace water in the reaction medium or as a process aid for downstream separation. Nowadays, manufacturers are increasingly requested to avoid and substitute solvents with hazardous potential. Therefore, the solvent selection must account for potential environmental hazards, health and safety problems, in addition to fulfilling the ideal characteristics for application in a process. For the first time, criteria including Environment, Health and Safety (EHS), as well as the technical requirements for reaction and... (More)

The application of conventional organic solvents has been essential in several steps of bioprocesses in order to achieve sufficient economic efficiency. The use of organic solvents is frequently used either to partly or fully replace water in the reaction medium or as a process aid for downstream separation. Nowadays, manufacturers are increasingly requested to avoid and substitute solvents with hazardous potential. Therefore, the solvent selection must account for potential environmental hazards, health and safety problems, in addition to fulfilling the ideal characteristics for application in a process. For the first time, criteria including Environment, Health and Safety (EHS), as well as the technical requirements for reaction and separation have been reviewed, collected and integrated in a single organic solvent screening strategy to be used as a guideline for narrowing down the list of solvents to test experimentally. Additionally, we have also included a solvent selection guide based on the methodology developed in the Innovative Medicines Initiative CHEM21 (IMI CHEM21) project and applied specifically to water-immiscible solvents commonly used in bioprocesses.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Bioprocesses, Biphasic systems, Downstream processing, In situ product removal, Organic solvents screening
in
Biotechnology Advances
volume
36
issue
7
pages
1801 - 1814
publisher
Elsevier
external identifiers
  • scopus:85049635187
  • pmid:29864458
ISSN
0734-9750
DOI
10.1016/j.biotechadv.2018.05.007
language
English
LU publication?
yes
id
877bef66-1b50-4143-81b0-def66701523f
date added to LUP
2018-07-26 13:33:57
date last changed
2025-01-08 12:39:22
@article{877bef66-1b50-4143-81b0-def66701523f,
  abstract     = {{<p>The application of conventional organic solvents has been essential in several steps of bioprocesses in order to achieve sufficient economic efficiency. The use of organic solvents is frequently used either to partly or fully replace water in the reaction medium or as a process aid for downstream separation. Nowadays, manufacturers are increasingly requested to avoid and substitute solvents with hazardous potential. Therefore, the solvent selection must account for potential environmental hazards, health and safety problems, in addition to fulfilling the ideal characteristics for application in a process. For the first time, criteria including Environment, Health and Safety (EHS), as well as the technical requirements for reaction and separation have been reviewed, collected and integrated in a single organic solvent screening strategy to be used as a guideline for narrowing down the list of solvents to test experimentally. Additionally, we have also included a solvent selection guide based on the methodology developed in the Innovative Medicines Initiative CHEM21 (IMI CHEM21) project and applied specifically to water-immiscible solvents commonly used in bioprocesses.</p>}},
  author       = {{Rosinha Grundtvig, Inês P. and Heintz, Søren and Krühne, Ulrich and Gernaey, Krist V. and Adlercreutz, Patrick and Hayler, John D. and Wells, Andy S. and Woodley, John M.}},
  issn         = {{0734-9750}},
  keywords     = {{Bioprocesses; Biphasic systems; Downstream processing; In situ product removal; Organic solvents screening}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{1801--1814}},
  publisher    = {{Elsevier}},
  series       = {{Biotechnology Advances}},
  title        = {{Screening of organic solvents for bioprocesses using aqueous-organic two-phase systems}},
  url          = {{http://dx.doi.org/10.1016/j.biotechadv.2018.05.007}},
  doi          = {{10.1016/j.biotechadv.2018.05.007}},
  volume       = {{36}},
  year         = {{2018}},
}