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Association of family history of type 2 diabetes with prostate cancer : A national cohort study

Ji, Jianguang LU ; Sundquist, Jan LU and Sundquist, Kristina LU (2016) In Frontiers in Oncology 6(AUG).
Abstract

Background: Personal history of type 2 diabetes mellitus (T2DM) is associated with a lower incidence of prostate cancer, but the underlying mechanisms are largely unknown. We hypothesized that genetic factors that are involved in the development of T2DM might protect against prostate cancer. Methods: We used a few Swedish registers, including the Swedish Multigeneration Register and the Cancer Register, to examine the risk of prostate cancer among men with a family history of T2DM. Standardized incidence ratios were used to calculate the relative risk. Results: The overall risk of prostate cancer among men with a familial history of T2DM was 0.87 (95% CI: 0.86-0.89) as compared to matched controls. The risk was even lower for those... (More)

Background: Personal history of type 2 diabetes mellitus (T2DM) is associated with a lower incidence of prostate cancer, but the underlying mechanisms are largely unknown. We hypothesized that genetic factors that are involved in the development of T2DM might protect against prostate cancer. Methods: We used a few Swedish registers, including the Swedish Multigeneration Register and the Cancer Register, to examine the risk of prostate cancer among men with a family history of T2DM. Standardized incidence ratios were used to calculate the relative risk. Results: The overall risk of prostate cancer among men with a familial history of T2DM was 0.87 (95% CI: 0.86-0.89) as compared to matched controls. The risk was even lower for those multiple affected relatives with T2DM, and it was 0.86 for those with two affected relatives and 0.67 for those with three and more affected relatives. Conclusion: Family history of T2DM was associated with a lower incidence of prostate cancer, and the risk was even lower for those with more than one affected relative. Our study strongly suggests that genetic factors or shared familial factors, such as obesity, that contributed to T2DM may protect against prostate cancer.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Familial risk, Incidence, Prostate cancer, Type 2 diabetes
in
Frontiers in Oncology
volume
6
issue
AUG
publisher
Frontiers Media S. A.
external identifiers
  • scopus:84990045020
ISSN
2234-943X
DOI
10.3389/fonc.2016.00194
language
English
LU publication?
yes
id
8784c968-6d48-4cab-8501-fa2e49a327c0
date added to LUP
2016-12-20 06:55:49
date last changed
2017-01-01 08:43:54
@article{8784c968-6d48-4cab-8501-fa2e49a327c0,
  abstract     = {<p>Background: Personal history of type 2 diabetes mellitus (T2DM) is associated with a lower incidence of prostate cancer, but the underlying mechanisms are largely unknown. We hypothesized that genetic factors that are involved in the development of T2DM might protect against prostate cancer. Methods: We used a few Swedish registers, including the Swedish Multigeneration Register and the Cancer Register, to examine the risk of prostate cancer among men with a family history of T2DM. Standardized incidence ratios were used to calculate the relative risk. Results: The overall risk of prostate cancer among men with a familial history of T2DM was 0.87 (95% CI: 0.86-0.89) as compared to matched controls. The risk was even lower for those multiple affected relatives with T2DM, and it was 0.86 for those with two affected relatives and 0.67 for those with three and more affected relatives. Conclusion: Family history of T2DM was associated with a lower incidence of prostate cancer, and the risk was even lower for those with more than one affected relative. Our study strongly suggests that genetic factors or shared familial factors, such as obesity, that contributed to T2DM may protect against prostate cancer.</p>},
  articleno    = {194},
  author       = {Ji, Jianguang and Sundquist, Jan and Sundquist, Kristina},
  issn         = {2234-943X},
  keyword      = {Familial risk,Incidence,Prostate cancer,Type 2 diabetes},
  language     = {eng},
  month        = {08},
  number       = {AUG},
  publisher    = {Frontiers Media S. A.},
  series       = {Frontiers in Oncology},
  title        = {Association of family history of type 2 diabetes with prostate cancer : A national cohort study},
  url          = {http://dx.doi.org/10.3389/fonc.2016.00194},
  volume       = {6},
  year         = {2016},
}