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Consensus guidelines for the use and interpretation of angiogenesis assays

Nowak-Sliwinska, Patrycja; Alitalo, Kari; Allen, Elizabeth; Anisimov, Andrey; Aplin, Alfred C.; Auerbach, Robert; Augustin, Hellmut G.; Bates, David O.; van Beijnum, Judy R. and Bender, R. Hugh F., et al. (2018) In Angiogenesis p.1-108
Abstract

The formation of new blood vessels, or angiogenesis, is a complex process that plays important roles in growth and development, tissue and organ regeneration, as well as numerous pathological conditions. Angiogenesis undergoes multiple discrete steps that can be individually evaluated and quantified by a large number of bioassays. These independent assessments hold advantages but also have limitations. This article describes in vivo, ex vivo, and in vitro bioassays that are available for the evaluation of angiogenesis and highlights critical aspects that are relevant for their execution and proper interpretation. As such, this collaborative work is the first edition of consensus guidelines on angiogenesis bioassays to serve for current... (More)

The formation of new blood vessels, or angiogenesis, is a complex process that plays important roles in growth and development, tissue and organ regeneration, as well as numerous pathological conditions. Angiogenesis undergoes multiple discrete steps that can be individually evaluated and quantified by a large number of bioassays. These independent assessments hold advantages but also have limitations. This article describes in vivo, ex vivo, and in vitro bioassays that are available for the evaluation of angiogenesis and highlights critical aspects that are relevant for their execution and proper interpretation. As such, this collaborative work is the first edition of consensus guidelines on angiogenesis bioassays to serve for current and future reference.

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Angiogenesis, Aortic ring, Chorioallantoic membrane (CAM), Corneal angiogenesis, Endothelial cell migration, Hindlimb ischemia, Intussusceptive angiogenesis, Microfluidic, Myocardial angiogenesis, Plug assay, Proliferation, Recombinant proteins, Retinal vasculature, Tip cells, Vascular network, Vessel co-option, Zebrafish
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Angiogenesis
pages
108 pages
publisher
Springer Netherlands
external identifiers
  • scopus:85046903965
ISSN
0969-6970
DOI
10.1007/s10456-018-9613-x
language
English
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yes
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878b766a-a6bf-4e63-b463-17fdede72164
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2018-05-23 13:29:27
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2018-11-11 05:02:25
@article{878b766a-a6bf-4e63-b463-17fdede72164,
  abstract     = {<p>The formation of new blood vessels, or angiogenesis, is a complex process that plays important roles in growth and development, tissue and organ regeneration, as well as numerous pathological conditions. Angiogenesis undergoes multiple discrete steps that can be individually evaluated and quantified by a large number of bioassays. These independent assessments hold advantages but also have limitations. This article describes in vivo, ex vivo, and in vitro bioassays that are available for the evaluation of angiogenesis and highlights critical aspects that are relevant for their execution and proper interpretation. As such, this collaborative work is the first edition of consensus guidelines on angiogenesis bioassays to serve for current and future reference.</p>},
  author       = {Nowak-Sliwinska, Patrycja and Alitalo, Kari and Allen, Elizabeth and Anisimov, Andrey and Aplin, Alfred C. and Auerbach, Robert and Augustin, Hellmut G. and Bates, David O. and van Beijnum, Judy R. and Bender, R. Hugh F. and Bergers, Gabriele and Bikfalvi, Andreas and Bischoff, Joyce and Böck, Barbara C. and Brooks, Peter C. and Bussolino, Federico and Cakir, Bertan and Carmeliet, Peter and Castranova, Daniel and Cimpean, Anca M. and Cleaver, Ondine and Coukos, George and Davis, George E. and de Palma, Michele and Dimberg, Anna and Dings, Ruud P.M. and Djonov, Valentin and Dudley, Andrew C. and Dufton, Neil P. and Fendt, Sarah Maria and Ferrara, Napoleone and Fruttiger, Marcus and Fukumura, Dai and Ghesquière, Bart and Gong, Yan and Griffin, Robert J. and Harris, Adrian L. and Hughes, Christopher C.W. and Hultgren, Nan W. and Iruela-Arispe, M. Luisa and Irving, Melita and Jain, Rakesh K. and Kalluri, Raghu and Kalucka, Joanna and Kerbel, Robert S. and Kitajewski, Jan and Klaassen, Ingeborg and Kleinmann, Hynda K. and Koolwijk, Pieter and Kuczynski, Elisabeth and Kwak, Brenda R. and Marien, Koen and Melero-Martin, Juan M. and Munn, Lance L. and Nicosia, Roberto F. and Noel, Agnes and Nurro, Jussi and Olsson, Anna Karin and Petrova, Tatiana V. and Pietras, Kristian and Pili, Roberto and Pollard, Jeffrey W. and Post, Mark J. and Quax, Paul H.A. and Rabinovich, Gabriel A. and Raica, Marius and Randi, Anna M. and Ribatti, Domenico and Ruegg, Curzio and Schlingemann, Reinier O. and Schulte-Merker, Stefan and Smith, Lois E.H. and Song, Jonathan W. and Stacker, Steven A. and Stalin, Jimmy and Stratman, Amber N. and van de Velde, Maureen and van Hinsbergh, Victor W.M. and Vermeulen, Peter B. and Waltenberger, Johannes and Weinstein, Brant M. and Xin, Hong and Yetkin-Arik, Bahar and Yla-Herttuala, Seppo and Yoder, Mervin C. and Griffioen, Arjan W.},
  issn         = {0969-6970},
  keyword      = {Angiogenesis,Aortic ring,Chorioallantoic membrane (CAM),Corneal angiogenesis,Endothelial cell migration,Hindlimb ischemia,Intussusceptive angiogenesis,Microfluidic,Myocardial angiogenesis,Plug assay,Proliferation,Recombinant proteins,Retinal vasculature,Tip cells,Vascular network,Vessel co-option,Zebrafish},
  language     = {eng},
  month        = {05},
  pages        = {1--108},
  publisher    = {Springer Netherlands},
  series       = {Angiogenesis},
  title        = {Consensus guidelines for the use and interpretation of angiogenesis assays},
  url          = {http://dx.doi.org/10.1007/s10456-018-9613-x},
  year         = {2018},
}