Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Development of MHz X-ray phase contrast imaging at the European XFEL

Koliyadu, Jayanath C.P. ; Moško, Daniel ; Asimakopoulou, Eleni Myrto LU orcid ; Bellucci, Valerio ; Birnšteinová, Šarlota ; Bean, Richard ; Letrun, Romain ; Kim, Chan ; Kirkwood, Henry and Giovanetti, Gabriele , et al. (2025) In Journal of Synchrotron Radiation 32. p.17-28
Abstract

We report on recent developments that enable megahertz hard X-ray phase contrast imaging (MHz XPCI) experiments at the Single Particles, Clusters, and Biomolecules and Serial Femtosecond Crystallography (SPB/SFX) instrument of the European XFEL facility (EuXFEL). We describe the technical implementation of the key components, including an MHz fast camera and a modular indirect X-ray microscope system based on fast scintillators coupled through a high-resolution optical microscope, which enable full-field X-ray microscopy with phase contrast of fast and irreversible phenomena. The image quality for MHz XPCI data showed significant improvement compared with a pilot demonstration of the technique using parallel beam illumination, which... (More)

We report on recent developments that enable megahertz hard X-ray phase contrast imaging (MHz XPCI) experiments at the Single Particles, Clusters, and Biomolecules and Serial Femtosecond Crystallography (SPB/SFX) instrument of the European XFEL facility (EuXFEL). We describe the technical implementation of the key components, including an MHz fast camera and a modular indirect X-ray microscope system based on fast scintillators coupled through a high-resolution optical microscope, which enable full-field X-ray microscopy with phase contrast of fast and irreversible phenomena. The image quality for MHz XPCI data showed significant improvement compared with a pilot demonstration of the technique using parallel beam illumination, which also allows access to up to 24 keV photon energies at the SPB/SFX instrument of the EuXFEL. With these developments, MHz XPCI was implemented as a new method offered for a broad user community (academic and industrial) and is accessible via standard user proposals. Furthermore, intra-Train pulse diagnostics with a high few-micrometre spatial resolution and recording up to 128 images of consecutive pulses in a train at up to 1.1 MHz repetition rate is available upstream of the instrument. Together with the diagnostic camera upstream of the instrument and the MHz XPCI setup at the SPB/SFX instrument, simultaneous two-plane measurements for future beam studies and feedback for machine parameter tuning are now possible.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; and (Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
European XFEL, indirect MHz X-ray detector, Megahertz sampling, pulse-resolved imaging, X-ray phase contrast imaging
in
Journal of Synchrotron Radiation
volume
32
pages
12 pages
publisher
International Union of Crystallography
external identifiers
  • pmid:39565194
  • scopus:85214529961
ISSN
0909-0495
DOI
10.1107/S160057752400986X
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2025 International Union of Crystallography. All rights reserved.
id
87b0103c-ab9c-4f47-a286-13de5721197d
date added to LUP
2025-03-24 14:35:46
date last changed
2025-06-02 17:34:36
@article{87b0103c-ab9c-4f47-a286-13de5721197d,
  abstract     = {{<p>We report on recent developments that enable megahertz hard X-ray phase contrast imaging (MHz XPCI) experiments at the Single Particles, Clusters, and Biomolecules and Serial Femtosecond Crystallography (SPB/SFX) instrument of the European XFEL facility (EuXFEL). We describe the technical implementation of the key components, including an MHz fast camera and a modular indirect X-ray microscope system based on fast scintillators coupled through a high-resolution optical microscope, which enable full-field X-ray microscopy with phase contrast of fast and irreversible phenomena. The image quality for MHz XPCI data showed significant improvement compared with a pilot demonstration of the technique using parallel beam illumination, which also allows access to up to 24 keV photon energies at the SPB/SFX instrument of the EuXFEL. With these developments, MHz XPCI was implemented as a new method offered for a broad user community (academic and industrial) and is accessible via standard user proposals. Furthermore, intra-Train pulse diagnostics with a high few-micrometre spatial resolution and recording up to 128 images of consecutive pulses in a train at up to 1.1 MHz repetition rate is available upstream of the instrument. Together with the diagnostic camera upstream of the instrument and the MHz XPCI setup at the SPB/SFX instrument, simultaneous two-plane measurements for future beam studies and feedback for machine parameter tuning are now possible.</p>}},
  author       = {{Koliyadu, Jayanath C.P. and Moško, Daniel and Asimakopoulou, Eleni Myrto and Bellucci, Valerio and Birnšteinová, Šarlota and Bean, Richard and Letrun, Romain and Kim, Chan and Kirkwood, Henry and Giovanetti, Gabriele and Jardon, Nerea and Szuba, Janusz and Guest, Trey and Koch, Andreas and Grünert, Jan and Szeles, Peter and Villanueva-Perez, Pablo and Reuter, Fabian and Ohl, Claus Dieter and Noack, Mike Andreas and Garcia-Moreno, Francisco and Kuglerová-Valdová, Zuzana and Juha, Libor and Nikl, Martin and Yashiro, Wataru and Soyama, Hitoshi and Eakins, Daniel and Korsunsky, Alexander M. and Uličný, Jozef and Meents, Alke and Chapman, Henry N. and Mancuso, Adrian P. and Sato, Tokushi and Vagovič, Patrik}},
  issn         = {{0909-0495}},
  keywords     = {{European XFEL; indirect MHz X-ray detector; Megahertz sampling; pulse-resolved imaging; X-ray phase contrast imaging}},
  language     = {{eng}},
  month        = {{01}},
  pages        = {{17--28}},
  publisher    = {{International Union of Crystallography}},
  series       = {{Journal of Synchrotron Radiation}},
  title        = {{Development of MHz X-ray phase contrast imaging at the European XFEL}},
  url          = {{http://dx.doi.org/10.1107/S160057752400986X}},
  doi          = {{10.1107/S160057752400986X}},
  volume       = {{32}},
  year         = {{2025}},
}