The amino-terminal phosphorylation sites of C-MYC are frequently mutated in Burkitt's lymphoma lines but not in mouse plasmacytomas and rat immunocytomas
(1995) In European Journal of Cancer 31A(12). p.104-2099- Abstract
We sequenced the region encoding the amino-terminal phosphorylation sites of C-MYC in the Ig/MYC translocation-carrying Burkitt lymphomas (BL), mouse plasmacytomas (MPC) and rat immunocytomas (RIC). Mutations affecting the Thr-58 codon or the immediate flanking region were found in seven of the 10 in vitro propagated BL lines. No mutations were found in any of the eight BL biopsies analysed. Germ-line sequences were also found in six in vivo and five in vitro passaged MPCs and in four in vivo transplanted RICs. These findings indicate that mutations in this region do not represent a general phenomena in Ig/MYC translocation-carrying tumours, but may confer growth advantage on BL cells under continuous in vitro propagation.
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- author
- Axelson, H LU ; Henriksson, M LU ; Wang, Y LU ; Magnusson, K P and Klein, G
- organization
- publishing date
- 1995-11
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Animals, Base Sequence, Burkitt Lymphoma, Genes, myc, Humans, Leukemia, Lymphocytic, Chronic, B-Cell, Mice, Molecular Sequence Data, Phosphorylation, Plasmacytoma, Point Mutation, Polymerase Chain Reaction, Rats, Translocation, Genetic, Tumor Cells, Cultured
- in
- European Journal of Cancer
- volume
- 31A
- issue
- 12
- pages
- 6 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:8562172
- scopus:0029176520
- ISSN
- 0959-8049
- language
- English
- LU publication?
- yes
- id
- 87c83116-f84d-44c7-8b49-ede1e44205dd
- date added to LUP
- 2016-08-09 09:18:39
- date last changed
- 2024-01-04 10:34:20
@article{87c83116-f84d-44c7-8b49-ede1e44205dd, abstract = {{<p>We sequenced the region encoding the amino-terminal phosphorylation sites of C-MYC in the Ig/MYC translocation-carrying Burkitt lymphomas (BL), mouse plasmacytomas (MPC) and rat immunocytomas (RIC). Mutations affecting the Thr-58 codon or the immediate flanking region were found in seven of the 10 in vitro propagated BL lines. No mutations were found in any of the eight BL biopsies analysed. Germ-line sequences were also found in six in vivo and five in vitro passaged MPCs and in four in vivo transplanted RICs. These findings indicate that mutations in this region do not represent a general phenomena in Ig/MYC translocation-carrying tumours, but may confer growth advantage on BL cells under continuous in vitro propagation.</p>}}, author = {{Axelson, H and Henriksson, M and Wang, Y and Magnusson, K P and Klein, G}}, issn = {{0959-8049}}, keywords = {{Animals; Base Sequence; Burkitt Lymphoma; Genes, myc; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Mice; Molecular Sequence Data; Phosphorylation; Plasmacytoma; Point Mutation; Polymerase Chain Reaction; Rats; Translocation, Genetic; Tumor Cells, Cultured}}, language = {{eng}}, number = {{12}}, pages = {{104--2099}}, publisher = {{Elsevier}}, series = {{European Journal of Cancer}}, title = {{The amino-terminal phosphorylation sites of C-MYC are frequently mutated in Burkitt's lymphoma lines but not in mouse plasmacytomas and rat immunocytomas}}, volume = {{31A}}, year = {{1995}}, }