Advanced

Association between plasma phospholipid saturated fatty acids and metabolic markers of lipid, hepatic, inflammation and glycaemic pathways in eight European countries : A cross-sectional analysis in the EPIC-InterAct study

Zheng, Ju Sheng; Sharp, Stephen J.; Imamura, Fumiaki; Koulman, Albert; Schulze, Matthias B.; Ye, Zheng; Griffin, Jules; Guevara, Marcela; Huerta, José María and Kröger, Janine, et al. (2017) In BMC Medicine 15(1).
Abstract

Background: Accumulating evidence suggests that individual circulating saturated fatty acids (SFAs) are heterogeneous in their associations with cardio-metabolic diseases, but evidence about associations of SFAs with metabolic markers of different pathogenic pathways is limited. We aimed to examine the associations between plasma phospholipid SFAs and the metabolic markers of lipid, hepatic, glycaemic and inflammation pathways. Methods: We measured nine individual plasma phospholipid SFAs and derived three SFA groups (odd-chain: C15:0 + C17:0, even-chain: C14:0 + C16:0 + C18:0, and very-long-chain: C20:0 + C22:0 + C23:0 + C24:0) in individuals from the subcohort of the European Prospective Investigation into Cancer and Nutrition... (More)

Background: Accumulating evidence suggests that individual circulating saturated fatty acids (SFAs) are heterogeneous in their associations with cardio-metabolic diseases, but evidence about associations of SFAs with metabolic markers of different pathogenic pathways is limited. We aimed to examine the associations between plasma phospholipid SFAs and the metabolic markers of lipid, hepatic, glycaemic and inflammation pathways. Methods: We measured nine individual plasma phospholipid SFAs and derived three SFA groups (odd-chain: C15:0 + C17:0, even-chain: C14:0 + C16:0 + C18:0, and very-long-chain: C20:0 + C22:0 + C23:0 + C24:0) in individuals from the subcohort of the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study across eight European countries. Using linear regression in 15,919 subcohort members, adjusted for potential confounders and corrected for multiple testing, we examined cross-sectional associations of SFAs with 13 metabolic markers. Multiplicative interactions of the three SFA groups with pre-specified factors, including body mass index (BMI) and alcohol consumption, were tested. Results: Higher levels of odd-chain SFA group were associated with lower levels of major lipids (total cholesterol (TC), triglycerides, apolipoprotein A-1 (ApoA1), apolipoprotein B (ApoB)) and hepatic markers (alanine transaminase (ALT), aspartate transaminase (AST), gamma-glutamyl transferase (GGT)). Higher even-chain SFA group levels were associated with higher levels of low-density lipoprotein cholesterol (LDL-C), TC/high-density lipoprotein cholesterol (HDL-C) ratio, triglycerides, ApoB, ApoB/A1 ratio, ALT, AST, GGT and CRP, and lower levels of HDL-C and ApoA1. Very-long-chain SFA group levels showed inverse associations with triglycerides, ApoA1 and GGT, and positive associations with TC, LDL-C, TC/HDL-C, ApoB and ApoB/A1. Associations were generally stronger at higher levels of BMI or alcohol consumption. Conclusions: Subtypes of SFAs are associated in a differential way with metabolic markers of lipid metabolism, liver function and chronic inflammation, suggesting that odd-chain SFAs are associated with lower metabolic risk and even-chain SFAs with adverse metabolic risk, whereas mixed findings were obtained for very-long-chain SFAs. The clinical and biochemical implications of these findings may vary by adiposity and alcohol intake.

(Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Even-chain, Glycaemic, Hepatic, Inflammation, Lipids, Metabolic markers, Odd-chain, Saturated fatty acids, Very-long-chain
in
BMC Medicine
volume
15
issue
1
publisher
BioMed Central
external identifiers
  • scopus:85034219449
  • wos:000415290800001
ISSN
1741-7015
DOI
10.1186/s12916-017-0968-4
language
English
LU publication?
yes
id
8803677f-9b52-4741-817e-d6716d469233
date added to LUP
2017-12-15 14:50:19
date last changed
2018-05-29 10:10:40
@article{8803677f-9b52-4741-817e-d6716d469233,
  abstract     = {<p>Background: Accumulating evidence suggests that individual circulating saturated fatty acids (SFAs) are heterogeneous in their associations with cardio-metabolic diseases, but evidence about associations of SFAs with metabolic markers of different pathogenic pathways is limited. We aimed to examine the associations between plasma phospholipid SFAs and the metabolic markers of lipid, hepatic, glycaemic and inflammation pathways. Methods: We measured nine individual plasma phospholipid SFAs and derived three SFA groups (odd-chain: C15:0 + C17:0, even-chain: C14:0 + C16:0 + C18:0, and very-long-chain: C20:0 + C22:0 + C23:0 + C24:0) in individuals from the subcohort of the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study across eight European countries. Using linear regression in 15,919 subcohort members, adjusted for potential confounders and corrected for multiple testing, we examined cross-sectional associations of SFAs with 13 metabolic markers. Multiplicative interactions of the three SFA groups with pre-specified factors, including body mass index (BMI) and alcohol consumption, were tested. Results: Higher levels of odd-chain SFA group were associated with lower levels of major lipids (total cholesterol (TC), triglycerides, apolipoprotein A-1 (ApoA1), apolipoprotein B (ApoB)) and hepatic markers (alanine transaminase (ALT), aspartate transaminase (AST), gamma-glutamyl transferase (GGT)). Higher even-chain SFA group levels were associated with higher levels of low-density lipoprotein cholesterol (LDL-C), TC/high-density lipoprotein cholesterol (HDL-C) ratio, triglycerides, ApoB, ApoB/A1 ratio, ALT, AST, GGT and CRP, and lower levels of HDL-C and ApoA1. Very-long-chain SFA group levels showed inverse associations with triglycerides, ApoA1 and GGT, and positive associations with TC, LDL-C, TC/HDL-C, ApoB and ApoB/A1. Associations were generally stronger at higher levels of BMI or alcohol consumption. Conclusions: Subtypes of SFAs are associated in a differential way with metabolic markers of lipid metabolism, liver function and chronic inflammation, suggesting that odd-chain SFAs are associated with lower metabolic risk and even-chain SFAs with adverse metabolic risk, whereas mixed findings were obtained for very-long-chain SFAs. The clinical and biochemical implications of these findings may vary by adiposity and alcohol intake.</p>},
  articleno    = {203},
  author       = {Zheng, Ju Sheng and Sharp, Stephen J. and Imamura, Fumiaki and Koulman, Albert and Schulze, Matthias B. and Ye, Zheng and Griffin, Jules and Guevara, Marcela and Huerta, José María and Kröger, Janine and Sluijs, Ivonne and Agudo, Antonio and Barricarte, Aurelio and Boeing, Heiner and Colorado-Yohar, Sandra and Dow, Courtney and Dorronsoro, Miren and Dinesen, Pia T. and Fagherazzi, Guy and Franks, Paul W. and Feskens, Edith J.M. and Kühn, Tilman and Katzke, Verena Andrea and Key, Timothy J. and Khaw, Kay Tee and de Magistris, Maria Santucci and Mancini, Francesca Romana and Molina-Portillo, Elena and Nilsson, Peter M. and Olsen, Anja and Overvad, Kim and Palli, Domenico and Quirós, Jose Ramón and Rolandsson, Olov and Ricceri, Fulvio and Spijkerman, Annemieke M.W. and Slimani, Nadia and Tagliabue, Giovanna and Tjonneland, Anne and Tumino, Rosario and van der Schouw, Yvonne T. and Langenberg, Claudia and Riboli, Elio and Forouhi, Nita G. and Wareham, Nicholas J.},
  issn         = {1741-7015},
  keyword      = {Even-chain,Glycaemic,Hepatic,Inflammation,Lipids,Metabolic markers,Odd-chain,Saturated fatty acids,Very-long-chain},
  language     = {eng},
  month        = {11},
  number       = {1},
  publisher    = {BioMed Central},
  series       = {BMC Medicine},
  title        = {Association between plasma phospholipid saturated fatty acids and metabolic markers of lipid, hepatic, inflammation and glycaemic pathways in eight European countries : A cross-sectional analysis in the EPIC-InterAct study},
  url          = {http://dx.doi.org/10.1186/s12916-017-0968-4},
  volume       = {15},
  year         = {2017},
}