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Vortex ring behavior provides the epigenetic blueprint for the human heart.

Arvidsson, Per LU ; Kovács, Sándor J; Töger, Johannes LU ; Borgquist, Rasmus LU ; Heiberg, Einar LU ; Carlsson, Marcus LU and Arheden, Håkan LU (2016) In Scientific Reports 6.
Abstract
The laws of fluid dynamics govern vortex ring formation and precede cardiac development by billions of years, suggesting that diastolic vortex ring formation is instrumental in defining the shape of the heart. Using novel and validated magnetic resonance imaging measurements, we show that the healthy left ventricle moves in tandem with the expanding vortex ring, indicating that cardiac form and function is epigenetically optimized to accommodate vortex ring formation for volume pumping. Healthy hearts demonstrate a strong coupling between vortex and cardiac volumes (R(2) = 0.83), but this optimized phenotype is lost in heart failure, suggesting restoration of normal vortex ring dynamics as a new, and possibly important consideration for... (More)
The laws of fluid dynamics govern vortex ring formation and precede cardiac development by billions of years, suggesting that diastolic vortex ring formation is instrumental in defining the shape of the heart. Using novel and validated magnetic resonance imaging measurements, we show that the healthy left ventricle moves in tandem with the expanding vortex ring, indicating that cardiac form and function is epigenetically optimized to accommodate vortex ring formation for volume pumping. Healthy hearts demonstrate a strong coupling between vortex and cardiac volumes (R(2) = 0.83), but this optimized phenotype is lost in heart failure, suggesting restoration of normal vortex ring dynamics as a new, and possibly important consideration for individualized heart failure treatment. Vortex ring volume was unrelated to early rapid filling (E-wave) velocity in patients and controls. Characteristics of vortex-wall interaction provide unique physiologic and mechanistic information about cardiac diastolic function that may be applied to guide the design and implantation of prosthetic valves, and have potential clinical utility as therapeutic targets for tailored medicine or measures of cardiac health. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scientific Reports
volume
6
publisher
Nature Publishing Group
external identifiers
  • pmid:26915473
  • scopus:84959449463
  • wos:000370922300001
ISSN
2045-2322
DOI
10.1038/srep22021
language
English
LU publication?
yes
id
b7bdc9d4-77e4-44e5-bfe8-6177793748c6 (old id 8821641)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26915473?dopt=Abstract
date added to LUP
2016-03-02 13:53:19
date last changed
2017-11-05 03:52:53
@article{b7bdc9d4-77e4-44e5-bfe8-6177793748c6,
  abstract     = {The laws of fluid dynamics govern vortex ring formation and precede cardiac development by billions of years, suggesting that diastolic vortex ring formation is instrumental in defining the shape of the heart. Using novel and validated magnetic resonance imaging measurements, we show that the healthy left ventricle moves in tandem with the expanding vortex ring, indicating that cardiac form and function is epigenetically optimized to accommodate vortex ring formation for volume pumping. Healthy hearts demonstrate a strong coupling between vortex and cardiac volumes (R(2) = 0.83), but this optimized phenotype is lost in heart failure, suggesting restoration of normal vortex ring dynamics as a new, and possibly important consideration for individualized heart failure treatment. Vortex ring volume was unrelated to early rapid filling (E-wave) velocity in patients and controls. Characteristics of vortex-wall interaction provide unique physiologic and mechanistic information about cardiac diastolic function that may be applied to guide the design and implantation of prosthetic valves, and have potential clinical utility as therapeutic targets for tailored medicine or measures of cardiac health.},
  articleno    = {22021},
  author       = {Arvidsson, Per and Kovács, Sándor J and Töger, Johannes and Borgquist, Rasmus and Heiberg, Einar and Carlsson, Marcus and Arheden, Håkan},
  issn         = {2045-2322},
  language     = {eng},
  publisher    = {Nature Publishing Group},
  series       = {Scientific Reports},
  title        = {Vortex ring behavior provides the epigenetic blueprint for the human heart.},
  url          = {http://dx.doi.org/10.1038/srep22021},
  volume       = {6},
  year         = {2016},
}