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Recurrent bacteremia with Streptococcus dysgalactiae: a case-control study.

Trell, Kristina LU ; Sendi, Parham and Rasmussen, Magnus LU (2016) In Diagnostic Microbiology and Infectious Disease
Abstract
Beta-hemolytic streptococci of groups C and G, designated as Streptococcus dysgalactiae (SD), can cause severe and recurring invasive infections. In this case-control study, we aimed to identify clinical and molecular risk factors for recurrence of SD bacteremia. Twenty-two cases of recurrent SD bacteremia were identified, and median time between episodes was 6 months. The most frequent clinical manifestation was skin and soft tissue infection. Cases and 92 controls, with single-episode SD bacteremia, showed similar demographics, had similar Charlson comorbidity scores, and had similar clinical presentations. Thirty-day fatality was 13% among controls, whereas none of 22 cases died. In 19 cases (86%), the same emm type was encountered in... (More)
Beta-hemolytic streptococci of groups C and G, designated as Streptococcus dysgalactiae (SD), can cause severe and recurring invasive infections. In this case-control study, we aimed to identify clinical and molecular risk factors for recurrence of SD bacteremia. Twenty-two cases of recurrent SD bacteremia were identified, and median time between episodes was 6 months. The most frequent clinical manifestation was skin and soft tissue infection. Cases and 92 controls, with single-episode SD bacteremia, showed similar demographics, had similar Charlson comorbidity scores, and had similar clinical presentations. Thirty-day fatality was 13% among controls, whereas none of 22 cases died. In 19 cases (86%), the same emm type was encountered in both episodes. SD isolates from recurrent episodes and from single episodes had a similar emm type distribution. Thus, we did not identify clinical risk factors for recurrences. The high proportion of identical emm types in recurrent episodes indicates a host-specific colonization. (Less)
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organization
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publication status
published
subject
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Diagnostic Microbiology and Infectious Disease
publisher
Elsevier
external identifiers
  • pmid:26906192
  • scopus:84959062448
  • wos:000375358000027
ISSN
1879-0070
DOI
10.1016/j.diagmicrobio.2016.01.011
language
English
LU publication?
yes
id
cbff591a-94c0-4b2e-a996-e4742cdd9d03 (old id 8821898)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26906192?dopt=Abstract
date added to LUP
2016-03-03 11:44:55
date last changed
2017-08-27 03:22:24
@article{cbff591a-94c0-4b2e-a996-e4742cdd9d03,
  abstract     = {Beta-hemolytic streptococci of groups C and G, designated as Streptococcus dysgalactiae (SD), can cause severe and recurring invasive infections. In this case-control study, we aimed to identify clinical and molecular risk factors for recurrence of SD bacteremia. Twenty-two cases of recurrent SD bacteremia were identified, and median time between episodes was 6 months. The most frequent clinical manifestation was skin and soft tissue infection. Cases and 92 controls, with single-episode SD bacteremia, showed similar demographics, had similar Charlson comorbidity scores, and had similar clinical presentations. Thirty-day fatality was 13% among controls, whereas none of 22 cases died. In 19 cases (86%), the same emm type was encountered in both episodes. SD isolates from recurrent episodes and from single episodes had a similar emm type distribution. Thus, we did not identify clinical risk factors for recurrences. The high proportion of identical emm types in recurrent episodes indicates a host-specific colonization.},
  author       = {Trell, Kristina and Sendi, Parham and Rasmussen, Magnus},
  issn         = {1879-0070},
  language     = {eng},
  month        = {01},
  publisher    = {Elsevier},
  series       = {Diagnostic Microbiology and Infectious Disease},
  title        = {Recurrent bacteremia with Streptococcus dysgalactiae: a case-control study.},
  url          = {http://dx.doi.org/10.1016/j.diagmicrobio.2016.01.011},
  year         = {2016},
}