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Increased expression of upstream TH2-cytokines in a mouse model of viral-induced asthma exacerbation.

Mahmutovic Persson, Irma LU ; Akbarshahi, Hamid LU ; Menzel, Mandy LU ; Brandelius, Angelica LU and Uller, Lena LU (2016) In Journal of Translational Medicine 14(1).
Abstract
Exacerbations of asthma caused by respiratory viral infections are serious conditions in need of novel treatment. To this end animal models of asthma exacerbations are warranted. We have shown that dsRNA challenges or rhinoviral infection produce exacerbation effects in mice with ovalbumin (OVA)-induced allergic asthma. However, house dust mite (HDM) is a more human asthma-relevant allergen than OVA. We thus hypothesised that dsRNA challenges in mice with HDM-induced experimental asthma would produce important translational features of asthma exacerbations.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Translational Medicine
volume
14
issue
1
publisher
BioMed Central
external identifiers
  • pmid:26879906
  • scopus:84957937645
  • wos:000370121300001
ISSN
1479-5876
DOI
10.1186/s12967-016-0808-x
language
English
LU publication?
yes
id
86e7172d-45c8-4b18-9965-e143581136e9 (old id 8825425)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26879906?dopt=Abstract
date added to LUP
2016-03-03 11:25:44
date last changed
2017-04-16 04:25:10
@article{86e7172d-45c8-4b18-9965-e143581136e9,
  abstract     = {Exacerbations of asthma caused by respiratory viral infections are serious conditions in need of novel treatment. To this end animal models of asthma exacerbations are warranted. We have shown that dsRNA challenges or rhinoviral infection produce exacerbation effects in mice with ovalbumin (OVA)-induced allergic asthma. However, house dust mite (HDM) is a more human asthma-relevant allergen than OVA. We thus hypothesised that dsRNA challenges in mice with HDM-induced experimental asthma would produce important translational features of asthma exacerbations.},
  articleno    = {52},
  author       = {Mahmutovic Persson, Irma and Akbarshahi, Hamid and Menzel, Mandy and Brandelius, Angelica and Uller, Lena},
  issn         = {1479-5876},
  language     = {eng},
  number       = {1},
  publisher    = {BioMed Central},
  series       = {Journal of Translational Medicine},
  title        = {Increased expression of upstream TH2-cytokines in a mouse model of viral-induced asthma exacerbation.},
  url          = {http://dx.doi.org/10.1186/s12967-016-0808-x},
  volume       = {14},
  year         = {2016},
}