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Long-chain saturated and monounsaturated fatty acids associate with development of premature infants up to 18 months of age.

Strandvik, Birgitta; Ntoumani, Eleni; Lundqvist, Cristina LU and Sabel, Karl-Göran (2016) In Prostaglandins, Leukotrienes and Essential Fatty Acids p.43-49
Abstract
Myelination is important perinatally and highly dependent on long-chain saturated and monounsaturated fatty acids. Long-chain polyunsaturated fatty acids, nowadays often supplemented, inhibit oleic acid synthesis. Using data from a premature cohort, we studied if nervonic, lignoceric and oleic acids correlated to growth and early development up to 18 months corrected age. Small for gestational age infants had lower concentrations than infants appropriate for gestational age. Only oleic acid was negatively correlated to long-chain polyunsaturated fatty acids. Oleic and lignoceric acids correlated to social interaction at one month, and nervonic acid to mental, psychomotor and behavioral development at 6, 10 and 18 months, also when adjusted... (More)
Myelination is important perinatally and highly dependent on long-chain saturated and monounsaturated fatty acids. Long-chain polyunsaturated fatty acids, nowadays often supplemented, inhibit oleic acid synthesis. Using data from a premature cohort, we studied if nervonic, lignoceric and oleic acids correlated to growth and early development up to 18 months corrected age. Small for gestational age infants had lower concentrations than infants appropriate for gestational age. Only oleic acid was negatively correlated to long-chain polyunsaturated fatty acids. Oleic and lignoceric acids correlated to social interaction at one month, and nervonic acid to mental, psychomotor and behavioral development at 6, 10 and 18 months, also when adjusted for several confounders. Negative association between oleic acid and long-chain polyunsaturated fatty acids suggests inhibition of delta-9 desaturase, and nervonic acid´s divergent correlation to lignoceric and oleic acids suggests different metabolism in neonatal period. Our results may have implications for the supplementation of premature infants. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Prostaglandins, Leukotrienes and Essential Fatty Acids
pages
43 - 49
publisher
Elsevier
external identifiers
  • pmid:26858144
  • wos:000374356900007
  • scopus:84962122619
ISSN
0952-3278
DOI
10.1016/j.plefa.2016.01.002
language
English
LU publication?
yes
id
c8120d27-9103-4daa-beb0-2f53dec072d0 (old id 8826077)
date added to LUP
2016-03-16 10:21:50
date last changed
2017-05-31 10:44:12
@article{c8120d27-9103-4daa-beb0-2f53dec072d0,
  abstract     = {Myelination is important perinatally and highly dependent on long-chain saturated and monounsaturated fatty acids. Long-chain polyunsaturated fatty acids, nowadays often supplemented, inhibit oleic acid synthesis. Using data from a premature cohort, we studied if nervonic, lignoceric and oleic acids correlated to growth and early development up to 18 months corrected age. Small for gestational age infants had lower concentrations than infants appropriate for gestational age. Only oleic acid was negatively correlated to long-chain polyunsaturated fatty acids. Oleic and lignoceric acids correlated to social interaction at one month, and nervonic acid to mental, psychomotor and behavioral development at 6, 10 and 18 months, also when adjusted for several confounders. Negative association between oleic acid and long-chain polyunsaturated fatty acids suggests inhibition of delta-9 desaturase, and nervonic acid´s divergent correlation to lignoceric and oleic acids suggests different metabolism in neonatal period. Our results may have implications for the supplementation of premature infants.},
  author       = {Strandvik, Birgitta and Ntoumani, Eleni and Lundqvist, Cristina and Sabel, Karl-Göran},
  issn         = {0952-3278},
  language     = {eng},
  pages        = {43--49},
  publisher    = {Elsevier},
  series       = {Prostaglandins, Leukotrienes and Essential Fatty Acids},
  title        = {Long-chain saturated and monounsaturated fatty acids associate with development of premature infants up to 18 months of age.},
  url          = {http://dx.doi.org/10.1016/j.plefa.2016.01.002},
  year         = {2016},
}