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Roles of signaling and transcriptional networks in pathological lymphangiogenesis.

Yoshimatsu, Yasuhiro; Miyazaki, Hideki LU and Watabe, Tetsuro (2016) In Advanced Drug Delivery Reviews 99. p.161-171
Abstract
Lymphangiogenesis, the generation of new lymphatic vessels, plays important roles in cancer metastasis. Outstanding progress during the past decade has dramatically increased the novel knowledge and insights of the mechanisms underlying the generation of new lymphatic vessels, the roles of transcription factors and lymphangiogenic growth factors during physiological development and pathological processes such as cancer and inflammation. Furthermore, an understanding of the molecular consequences during tumor lymphangiogenesis has provided chances to develop better diagnostic and therapeutic approaches that aim to limit the progression of cancer. In this article, we will explain the current knowledge of how lymphatic function is altered in... (More)
Lymphangiogenesis, the generation of new lymphatic vessels, plays important roles in cancer metastasis. Outstanding progress during the past decade has dramatically increased the novel knowledge and insights of the mechanisms underlying the generation of new lymphatic vessels, the roles of transcription factors and lymphangiogenic growth factors during physiological development and pathological processes such as cancer and inflammation. Furthermore, an understanding of the molecular consequences during tumor lymphangiogenesis has provided chances to develop better diagnostic and therapeutic approaches that aim to limit the progression of cancer. In this article, we will explain the current knowledge of how lymphatic function is altered in various pathological conditions including cancer progression. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Advanced Drug Delivery Reviews
volume
99
pages
161 - 171
publisher
Elsevier
external identifiers
  • pmid:26850127
  • scopus:84962615544
  • wos:000374421500004
ISSN
0169-409X
DOI
10.1016/j.addr.2016.01.020
language
English
LU publication?
yes
id
2e34ea38-09c6-480e-a6a8-71c7b43da354 (old id 8829159)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26850127?dopt=Abstract
date added to LUP
2016-03-02 10:01:29
date last changed
2017-09-18 11:29:09
@article{2e34ea38-09c6-480e-a6a8-71c7b43da354,
  abstract     = {Lymphangiogenesis, the generation of new lymphatic vessels, plays important roles in cancer metastasis. Outstanding progress during the past decade has dramatically increased the novel knowledge and insights of the mechanisms underlying the generation of new lymphatic vessels, the roles of transcription factors and lymphangiogenic growth factors during physiological development and pathological processes such as cancer and inflammation. Furthermore, an understanding of the molecular consequences during tumor lymphangiogenesis has provided chances to develop better diagnostic and therapeutic approaches that aim to limit the progression of cancer. In this article, we will explain the current knowledge of how lymphatic function is altered in various pathological conditions including cancer progression.},
  author       = {Yoshimatsu, Yasuhiro and Miyazaki, Hideki and Watabe, Tetsuro},
  issn         = {0169-409X},
  language     = {eng},
  month        = {02},
  pages        = {161--171},
  publisher    = {Elsevier},
  series       = {Advanced Drug Delivery Reviews},
  title        = {Roles of signaling and transcriptional networks in pathological lymphangiogenesis.},
  url          = {http://dx.doi.org/10.1016/j.addr.2016.01.020},
  volume       = {99},
  year         = {2016},
}