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Emerging aspects of nanotoxicology in health and disease: From agriculture and food sector to cancer therapeutics.

Piperigkou, Zoi; Karamanou, Konstantina; Engin, Ayse Basak; Gialeli, Chrysostomi LU ; Docea, Anca Oana; Vynios, Demitrios H; Pavão, Mauro S G; Golokhvast, Kirill S; Shtilman, Mikhail I and Argiris, Athanassios, et al. (2016) In Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 91(May). p.42-57
Abstract
Nanotechnology is an evolving scientific field that has allowed the manufacturing of materials with novel physicochemical and biological properties, offering a wide spectrum of potential applications. Properties of nanoparticles that contribute to their usefulness include their markedly increased surface area in relation to mass, surface reactivity and insolubility, ability to agglomerate or change size in different media and enhanced endurance over conventional-scale substance. Here, we review nanoparticle classification and their emerging applications in several fields; from active food packaging to drug delivery and cancer research. Nanotechnology has exciting therapeutic applications, including novel drug delivery for the treatment of... (More)
Nanotechnology is an evolving scientific field that has allowed the manufacturing of materials with novel physicochemical and biological properties, offering a wide spectrum of potential applications. Properties of nanoparticles that contribute to their usefulness include their markedly increased surface area in relation to mass, surface reactivity and insolubility, ability to agglomerate or change size in different media and enhanced endurance over conventional-scale substance. Here, we review nanoparticle classification and their emerging applications in several fields; from active food packaging to drug delivery and cancer research. Nanotechnology has exciting therapeutic applications, including novel drug delivery for the treatment of cancer. Additionally, we discuss that exposure to nanostructures incorporated to polymer composites, may result in potential human health risks. Therefore, the knowledge of processes, including absorption, distribution, metabolism and excretion, as well as careful toxicological assessment is critical in order to determine the effects of nanomaterials in humans and other biological systems. Expanding the knowledge of nanoparticle toxicity will facilitate designing of safer nanocomposites and their application in a beneficial manner. (Less)
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published
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in
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
volume
91
issue
May
pages
42 - 57
publisher
Elsevier
external identifiers
  • pmid:26969113
  • scopus:84960427574
  • wos:000375629200005
ISSN
1873-6351
DOI
10.1016/j.fct.2016.03.003
language
English
LU publication?
yes
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66b044b0-2510-46de-8c25-524c8a1a69ec (old id 8852574)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26969113?dopt=Abstract
date added to LUP
2016-03-16 15:50:29
date last changed
2017-09-18 11:28:39
@article{66b044b0-2510-46de-8c25-524c8a1a69ec,
  abstract     = {Nanotechnology is an evolving scientific field that has allowed the manufacturing of materials with novel physicochemical and biological properties, offering a wide spectrum of potential applications. Properties of nanoparticles that contribute to their usefulness include their markedly increased surface area in relation to mass, surface reactivity and insolubility, ability to agglomerate or change size in different media and enhanced endurance over conventional-scale substance. Here, we review nanoparticle classification and their emerging applications in several fields; from active food packaging to drug delivery and cancer research. Nanotechnology has exciting therapeutic applications, including novel drug delivery for the treatment of cancer. Additionally, we discuss that exposure to nanostructures incorporated to polymer composites, may result in potential human health risks. Therefore, the knowledge of processes, including absorption, distribution, metabolism and excretion, as well as careful toxicological assessment is critical in order to determine the effects of nanomaterials in humans and other biological systems. Expanding the knowledge of nanoparticle toxicity will facilitate designing of safer nanocomposites and their application in a beneficial manner.},
  author       = {Piperigkou, Zoi and Karamanou, Konstantina and Engin, Ayse Basak and Gialeli, Chrysostomi and Docea, Anca Oana and Vynios, Demitrios H and Pavão, Mauro S G and Golokhvast, Kirill S and Shtilman, Mikhail I and Argiris, Athanassios and Shishatskaya, Ekaterina and Tsatsakis, Aristidis M},
  issn         = {1873-6351},
  language     = {eng},
  number       = {May},
  pages        = {42--57},
  publisher    = {Elsevier},
  series       = {Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  title        = {Emerging aspects of nanotoxicology in health and disease: From agriculture and food sector to cancer therapeutics.},
  url          = {http://dx.doi.org/10.1016/j.fct.2016.03.003},
  volume       = {91},
  year         = {2016},
}