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Structural and Functional Progression in the Early Manifest Glaucoma Trial.

Öhnell, HannaMaria LU ; Heijl, Anders LU ; Brenner, Lena; Anderson, Harald LU and Bengtsson, Boel LU (2016) In Ophthalmology 123(6). p.1173-1180
Abstract
Purpose
To elucidate the temporal relationship between detection of glaucomatous optic disc progression, as assessed by fundus photography, and visual field progression.

Design
Prospective, randomized, longitudinal trial.

Participants
Three hundred six study eyes with manifest glaucoma with field loss and 192 fellow eyes without any field defect at the start of the trial, from a total of 249 subjects included in the Early Manifest Glaucoma Trial (EMGT), were assessed.

Methods
Evaluation of visual field progression and optic disc progression during an 8-year follow-up period. Three graders independently assessed optic disc progression in optic disc photographs. Visual field progression was assessed... (More)
Purpose
To elucidate the temporal relationship between detection of glaucomatous optic disc progression, as assessed by fundus photography, and visual field progression.

Design
Prospective, randomized, longitudinal trial.

Participants
Three hundred six study eyes with manifest glaucoma with field loss and 192 fellow eyes without any field defect at the start of the trial, from a total of 249 subjects included in the Early Manifest Glaucoma Trial (EMGT), were assessed.

Methods
Evaluation of visual field progression and optic disc progression during an 8-year follow-up period. Three graders independently assessed optic disc progression in optic disc photographs. Visual field progression was assessed using glaucoma change probability maps and the EMGT progression criterion.

Main Outcome Measures
Time to detection of visual field progression and optic disc progression.

Results
Among study eyes with manifest glaucoma, progression was detected in the visual field first in 163 eyes (52%) and in the optic disc first in 39 eyes (12%); in 1 eye (0%), it was found simultaneously with both methods. Among fellow eyes with normal fields, progression was detected in the visual field first in 28 eyes (15%) and in the optic disc first in 34 eyes (18%); in 1 eye (1%), it occurred simultaneously.

Conclusions
In eyes with manifest glaucoma, progression in the visual field was detected first more than 4 times as often as progression in the optic disc. Among fellow eyes without visual field loss at baseline, progression was detected first as frequently in the optic disc as in the visual field. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Ophthalmology
volume
123
issue
6
pages
1173 - 1180
publisher
Elsevier
external identifiers
  • pmid:26949119
  • scopus:84961184614
  • wos:000376506400009
ISSN
1549-4713
DOI
10.1016/j.ophtha.2016.01.039
language
English
LU publication?
yes
id
255f4815-342e-4904-b264-78bfc1cfb533 (old id 8856025)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26949119?dopt=Abstract
date added to LUP
2016-03-15 12:05:13
date last changed
2017-11-12 04:08:33
@article{255f4815-342e-4904-b264-78bfc1cfb533,
  abstract     = {Purpose<br/>To elucidate the temporal relationship between detection of glaucomatous optic disc progression, as assessed by fundus photography, and visual field progression.<br/><br/>Design<br/>Prospective, randomized, longitudinal trial.<br/><br/>Participants<br/>Three hundred six study eyes with manifest glaucoma with field loss and 192 fellow eyes without any field defect at the start of the trial, from a total of 249 subjects included in the Early Manifest Glaucoma Trial (EMGT), were assessed.<br/><br/>Methods<br/>Evaluation of visual field progression and optic disc progression during an 8-year follow-up period. Three graders independently assessed optic disc progression in optic disc photographs. Visual field progression was assessed using glaucoma change probability maps and the EMGT progression criterion.<br/><br/>Main Outcome Measures<br/>Time to detection of visual field progression and optic disc progression.<br/><br/>Results<br/>Among study eyes with manifest glaucoma, progression was detected in the visual field first in 163 eyes (52%) and in the optic disc first in 39 eyes (12%); in 1 eye (0%), it was found simultaneously with both methods. Among fellow eyes with normal fields, progression was detected in the visual field first in 28 eyes (15%) and in the optic disc first in 34 eyes (18%); in 1 eye (1%), it occurred simultaneously.<br/><br/>Conclusions<br/>In eyes with manifest glaucoma, progression in the visual field was detected first more than 4 times as often as progression in the optic disc. Among fellow eyes without visual field loss at baseline, progression was detected first as frequently in the optic disc as in the visual field.},
  author       = {Öhnell, HannaMaria and Heijl, Anders and Brenner, Lena and Anderson, Harald and Bengtsson, Boel},
  issn         = {1549-4713},
  language     = {eng},
  month        = {03},
  number       = {6},
  pages        = {1173--1180},
  publisher    = {Elsevier},
  series       = {Ophthalmology},
  title        = {Structural and Functional Progression in the Early Manifest Glaucoma Trial.},
  url          = {http://dx.doi.org/10.1016/j.ophtha.2016.01.039},
  volume       = {123},
  year         = {2016},
}