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Towards the modelling of ageing and atherosclerosis effects in ApoE(-/-) mice aortic tissue.

Waffenschmidt, Tobias; Cilla, Myriam; Sáez, Pablo; Pérez, Marta M; Martínez, Miguel A; Menzel, Andreas LU and Peña, Estefanía (2016) In Journal of Biomechanics
Abstract
The goal of this work consists in a quantitative analysis and constitutive modelling of ageing processes associated to plaque formation in mice arteries. Reliable information on the characteristic evolution of pressure-stretch curves due to the ageing effects is extracted from previous inflation test experiments. Furthermore, characteristic age-dependent material parameters are identified on the basis of a continuum-mechanics-based parameter optimisation technique. The results indicate that the aorta-stiffness of the healthy control mice remains basically constant irrespective of the diet-time and age. In contrast, significant differences exist within the material response and in consequence within the material parameters between the... (More)
The goal of this work consists in a quantitative analysis and constitutive modelling of ageing processes associated to plaque formation in mice arteries. Reliable information on the characteristic evolution of pressure-stretch curves due to the ageing effects is extracted from previous inflation test experiments. Furthermore, characteristic age-dependent material parameters are identified on the basis of a continuum-mechanics-based parameter optimisation technique. The results indicate that the aorta-stiffness of the healthy control mice remains basically constant irrespective of the diet-time and age. In contrast, significant differences exist within the material response and in consequence within the material parameters between the ApoE(-/-) and the control mice as well as for the different locations over the aorta which is underlined by our experimental observations. With regard to the temporal evolution of the material parameters, we observe that the material parameters for the ApoE(-/-) mice aortas exhibit a saturation-type increase with respect to age. (Less)
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Contribution to journal
publication status
published
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in
Journal of Biomechanics
publisher
Elsevier
external identifiers
  • pmid:26924660
  • scopus:84975729872
  • wos:000384857800010
ISSN
1873-2380
DOI
10.1016/j.jbiomech.2016.01.043
language
English
LU publication?
yes
id
96b7be4b-d50f-48e1-b628-c0e765dd4986 (old id 8857142)
date added to LUP
2016-03-21 15:05:18
date last changed
2017-11-05 03:21:36
@article{96b7be4b-d50f-48e1-b628-c0e765dd4986,
  abstract     = {The goal of this work consists in a quantitative analysis and constitutive modelling of ageing processes associated to plaque formation in mice arteries. Reliable information on the characteristic evolution of pressure-stretch curves due to the ageing effects is extracted from previous inflation test experiments. Furthermore, characteristic age-dependent material parameters are identified on the basis of a continuum-mechanics-based parameter optimisation technique. The results indicate that the aorta-stiffness of the healthy control mice remains basically constant irrespective of the diet-time and age. In contrast, significant differences exist within the material response and in consequence within the material parameters between the ApoE(-/-) and the control mice as well as for the different locations over the aorta which is underlined by our experimental observations. With regard to the temporal evolution of the material parameters, we observe that the material parameters for the ApoE(-/-) mice aortas exhibit a saturation-type increase with respect to age.},
  author       = {Waffenschmidt, Tobias and Cilla, Myriam and Sáez, Pablo and Pérez, Marta M and Martínez, Miguel A and Menzel, Andreas and Peña, Estefanía},
  issn         = {1873-2380},
  language     = {eng},
  month        = {02},
  publisher    = {Elsevier},
  series       = {Journal of Biomechanics},
  title        = {Towards the modelling of ageing and atherosclerosis effects in ApoE(-/-) mice aortic tissue.},
  url          = {http://dx.doi.org/10.1016/j.jbiomech.2016.01.043},
  year         = {2016},
}