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Splicing and polyadenylation of human papillomavirus type 16 mRNAs

Wu, Troy Chengjun LU ; Kajitani, Naoko LU and Schwartz, Stefan LU (2017) In International Journal of Molecular Sciences 18(2).
Abstract

The human papillomavirus type 16 (HPV16) life cycle can be divided into an early stage in which the HPV16 genomic DNA is replicated, and a late stage in which the HPV16 structural proteins are synthesized and virions are produced. A strong coupling between the viral life cycle and the differentiation state of the infected cell is highly characteristic of all HPVs. The switch from the HPV16 early gene expression program to the late requires a promoter switch, a polyadenylation signal switch and a shift in alternative splicing. A number of cis-acting RNA elements on the HPV16 mRNAs and cellular and viral factors interacting with these elements are involved in the control of HPV16 gene expression. This review summarizes our knowledge of... (More)

The human papillomavirus type 16 (HPV16) life cycle can be divided into an early stage in which the HPV16 genomic DNA is replicated, and a late stage in which the HPV16 structural proteins are synthesized and virions are produced. A strong coupling between the viral life cycle and the differentiation state of the infected cell is highly characteristic of all HPVs. The switch from the HPV16 early gene expression program to the late requires a promoter switch, a polyadenylation signal switch and a shift in alternative splicing. A number of cis-acting RNA elements on the HPV16 mRNAs and cellular and viral factors interacting with these elements are involved in the control of HPV16 gene expression. This review summarizes our knowledge of HPV16 cis-acting RNA elements and cellular and viral trans-acting factors that regulate HPV16 gene expression at the level of splicing and polyadenylation.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
hnRNP, HPV16, Human papillomavirus, Polyadenylation, Splicing, SR-protein
in
International Journal of Molecular Sciences
volume
18
issue
2
publisher
MOLECULAR DIVERSITY PRESERVATION INT
external identifiers
  • scopus:85012118441
  • wos:000395457700134
ISSN
1661-6596
DOI
10.3390/ijms18020366
language
English
LU publication?
yes
id
8890e1de-48da-4bab-8bca-5ef79525b950
date added to LUP
2017-02-22 13:38:45
date last changed
2018-01-07 11:51:55
@article{8890e1de-48da-4bab-8bca-5ef79525b950,
  abstract     = {<p>The human papillomavirus type 16 (HPV16) life cycle can be divided into an early stage in which the HPV16 genomic DNA is replicated, and a late stage in which the HPV16 structural proteins are synthesized and virions are produced. A strong coupling between the viral life cycle and the differentiation state of the infected cell is highly characteristic of all HPVs. The switch from the HPV16 early gene expression program to the late requires a promoter switch, a polyadenylation signal switch and a shift in alternative splicing. A number of cis-acting RNA elements on the HPV16 mRNAs and cellular and viral factors interacting with these elements are involved in the control of HPV16 gene expression. This review summarizes our knowledge of HPV16 cis-acting RNA elements and cellular and viral trans-acting factors that regulate HPV16 gene expression at the level of splicing and polyadenylation.</p>},
  articleno    = {366},
  author       = {Wu, Troy Chengjun and Kajitani, Naoko and Schwartz, Stefan},
  issn         = {1661-6596},
  keyword      = {hnRNP,HPV16,Human papillomavirus,Polyadenylation,Splicing,SR-protein},
  language     = {eng},
  month        = {02},
  number       = {2},
  publisher    = {MOLECULAR DIVERSITY PRESERVATION INT},
  series       = {International Journal of Molecular Sciences},
  title        = {Splicing and polyadenylation of human papillomavirus type 16 mRNAs},
  url          = {http://dx.doi.org/10.3390/ijms18020366},
  volume       = {18},
  year         = {2017},
}