Splicing and polyadenylation of human papillomavirus type 16 mRNAs
(2017) In International Journal of Molecular Sciences 18(2).- Abstract
The human papillomavirus type 16 (HPV16) life cycle can be divided into an early stage in which the HPV16 genomic DNA is replicated, and a late stage in which the HPV16 structural proteins are synthesized and virions are produced. A strong coupling between the viral life cycle and the differentiation state of the infected cell is highly characteristic of all HPVs. The switch from the HPV16 early gene expression program to the late requires a promoter switch, a polyadenylation signal switch and a shift in alternative splicing. A number of cis-acting RNA elements on the HPV16 mRNAs and cellular and viral factors interacting with these elements are involved in the control of HPV16 gene expression. This review summarizes our knowledge of... (More)
The human papillomavirus type 16 (HPV16) life cycle can be divided into an early stage in which the HPV16 genomic DNA is replicated, and a late stage in which the HPV16 structural proteins are synthesized and virions are produced. A strong coupling between the viral life cycle and the differentiation state of the infected cell is highly characteristic of all HPVs. The switch from the HPV16 early gene expression program to the late requires a promoter switch, a polyadenylation signal switch and a shift in alternative splicing. A number of cis-acting RNA elements on the HPV16 mRNAs and cellular and viral factors interacting with these elements are involved in the control of HPV16 gene expression. This review summarizes our knowledge of HPV16 cis-acting RNA elements and cellular and viral trans-acting factors that regulate HPV16 gene expression at the level of splicing and polyadenylation.
(Less)
- author
- Wu, Troy Chengjun LU ; Kajitani, Naoko LU and Schwartz, Stefan LU
- organization
- publishing date
- 2017-02-09
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- hnRNP, HPV16, Human papillomavirus, Polyadenylation, Splicing, SR-protein
- in
- International Journal of Molecular Sciences
- volume
- 18
- issue
- 2
- article number
- 366
- publisher
- MDPI AG
- external identifiers
-
- pmid:28208770
- wos:000395457700134
- scopus:85012118441
- ISSN
- 1661-6596
- DOI
- 10.3390/ijms18020366
- language
- English
- LU publication?
- yes
- id
- 8890e1de-48da-4bab-8bca-5ef79525b950
- date added to LUP
- 2017-02-22 13:38:45
- date last changed
- 2025-01-07 07:58:26
@article{8890e1de-48da-4bab-8bca-5ef79525b950,
abstract = {{<p>The human papillomavirus type 16 (HPV16) life cycle can be divided into an early stage in which the HPV16 genomic DNA is replicated, and a late stage in which the HPV16 structural proteins are synthesized and virions are produced. A strong coupling between the viral life cycle and the differentiation state of the infected cell is highly characteristic of all HPVs. The switch from the HPV16 early gene expression program to the late requires a promoter switch, a polyadenylation signal switch and a shift in alternative splicing. A number of cis-acting RNA elements on the HPV16 mRNAs and cellular and viral factors interacting with these elements are involved in the control of HPV16 gene expression. This review summarizes our knowledge of HPV16 cis-acting RNA elements and cellular and viral trans-acting factors that regulate HPV16 gene expression at the level of splicing and polyadenylation.</p>}},
author = {{Wu, Troy Chengjun and Kajitani, Naoko and Schwartz, Stefan}},
issn = {{1661-6596}},
keywords = {{hnRNP; HPV16; Human papillomavirus; Polyadenylation; Splicing; SR-protein}},
language = {{eng}},
month = {{02}},
number = {{2}},
publisher = {{MDPI AG}},
series = {{International Journal of Molecular Sciences}},
title = {{Splicing and polyadenylation of human papillomavirus type 16 mRNAs}},
url = {{http://dx.doi.org/10.3390/ijms18020366}},
doi = {{10.3390/ijms18020366}},
volume = {{18}},
year = {{2017}},
}