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Influence of CD4 or CD8 deficiency on collagen-induced arthritis

Ehinger, Magnus LU ; Vestberg, Mikael LU ; Johansson, Åsa C M LU ; Johannesson, Martina LU ; Svensson, Anders and Holmdahl, Rikard (2001) In Immunology 103(3). p.291-300
Abstract
The role of T cells in the mouse collagen-induced arthritis (CIA) model for rheumatoid arthritis is not clarified, and different results have been reported concerning the role of CD4 and CD8 T cells. To address this issue, we have investigated B10.Q mice deficient for CD4 or CD8. The mice lacking CD4 were found to be less susceptible to disease, but not completely resistant, whereas the CD8 deficiency had no significant impact on the disease. No difference in the development of late occurring relapses was noted. Interestingly, the CD4-deficient mice had a severely reduced response to the glycosylated form of the immunodominant type II collagen (CII) 256–270 peptide whereas the response to the non-glycosylated peptide was not significantly... (More)
The role of T cells in the mouse collagen-induced arthritis (CIA) model for rheumatoid arthritis is not clarified, and different results have been reported concerning the role of CD4 and CD8 T cells. To address this issue, we have investigated B10.Q mice deficient for CD4 or CD8. The mice lacking CD4 were found to be less susceptible to disease, but not completely resistant, whereas the CD8 deficiency had no significant impact on the disease. No difference in the development of late occurring relapses was noted. Interestingly, the CD4-deficient mice had a severely reduced response to the glycosylated form of the immunodominant type II collagen (CII) 256–270 peptide whereas the response to the non-glycosylated peptide was not significantly different. Furthermore, CD4-deficient mice had lower antibody responses to CII, explaining the lower disease susceptibility. In comparison with previously reported results, it is apparent that the lack of CD4 molecules has a different impact on CIA if present on different genetic backgrounds, findings that could possibly be related to the occurrence of different disease pathways of CIA in different mouse strains. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Immunology
volume
103
issue
3
pages
291 - 300
publisher
Wiley-Blackwell
external identifiers
  • scopus:0034942508
ISSN
0019-2805
DOI
10.1046/j.1365-2567.2001.01257.x
language
English
LU publication?
yes
id
88a7b86c-5cf0-410b-8f4b-88450e265855
date added to LUP
2024-06-05 10:53:59
date last changed
2024-06-06 04:02:24
@article{88a7b86c-5cf0-410b-8f4b-88450e265855,
  abstract     = {{The role of T cells in the mouse collagen-induced arthritis (CIA) model for rheumatoid arthritis is not clarified, and different results have been reported concerning the role of CD4 and CD8 T cells. To address this issue, we have investigated B10.Q mice deficient for CD4 or CD8. The mice lacking CD4 were found to be less susceptible to disease, but not completely resistant, whereas the CD8 deficiency had no significant impact on the disease. No difference in the development of late occurring relapses was noted. Interestingly, the CD4-deficient mice had a severely reduced response to the glycosylated form of the immunodominant type II collagen (CII) 256–270 peptide whereas the response to the non-glycosylated peptide was not significantly different. Furthermore, CD4-deficient mice had lower antibody responses to CII, explaining the lower disease susceptibility. In comparison with previously reported results, it is apparent that the lack of CD4 molecules has a different impact on CIA if present on different genetic backgrounds, findings that could possibly be related to the occurrence of different disease pathways of CIA in different mouse strains.}},
  author       = {{Ehinger, Magnus and Vestberg, Mikael and Johansson, Åsa C M and Johannesson, Martina and Svensson, Anders and Holmdahl, Rikard}},
  issn         = {{0019-2805}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{291--300}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Immunology}},
  title        = {{Influence of CD4 or CD8 deficiency on collagen-induced arthritis}},
  url          = {{http://dx.doi.org/10.1046/j.1365-2567.2001.01257.x}},
  doi          = {{10.1046/j.1365-2567.2001.01257.x}},
  volume       = {{103}},
  year         = {{2001}},
}