Aged garlic extract preserves cutaneous microcirculation in patients with increased risk for cardiovascular diseases : A double-blinded placebo-controlled study
(2019) In International Wound Journal 16(6). p.1487-1493- Abstract
Laser Doppler velocimetry estimates tissue perfusion providing a record of microvascular blood flow. Patients with heart disease or diabetes mellitus have impaired microvascular perfusion leading to impaired wound healing. Aged garlic extract (AGE) has a positive effect on vascular elasticity. This study aimed to assess the effect of long-term treatment with AGE on cutaneous tissue perfusion. A total of 122 patients with Framingham Risk Score ≥ 10 were randomised in a double-blinded manner to placebo or 2400 mg AGE daily for 1 year and monitored. Cutaneous microcirculation was measured at 0 and 12 months using laser Doppler velocimetry. A repeated measures analysis of variance (ANOVA) with a Greenhouse–Geisser correction determined that... (More)
Laser Doppler velocimetry estimates tissue perfusion providing a record of microvascular blood flow. Patients with heart disease or diabetes mellitus have impaired microvascular perfusion leading to impaired wound healing. Aged garlic extract (AGE) has a positive effect on vascular elasticity. This study aimed to assess the effect of long-term treatment with AGE on cutaneous tissue perfusion. A total of 122 patients with Framingham Risk Score ≥ 10 were randomised in a double-blinded manner to placebo or 2400 mg AGE daily for 1 year and monitored. Cutaneous microcirculation was measured at 0 and 12 months using laser Doppler velocimetry. A repeated measures analysis of variance (ANOVA) with a Greenhouse–Geisser correction determined that mean post-occlusive reactive hyperaemia differed significantly between time points. The mean percent change between the two time points 0 and 12 months was 102, 64 (174, 15)% change for AGE and 78, 62 (107, 92)% change for the placebo group (F[1, 120] = 5. 95, P < 0.016), 12 months of AGE increases the microcirculation in patients with an increased risk for cardiovascular events estimated using the Framingham risk score. Increased microcirculation could hypothetically facilitate wound healing.
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- author
- Wlosinska, Martine LU ; Nilsson, Ann Christin LU ; Hlebowicz, Joanna LU ; Malmsjö, Malin LU ; Fakhro, Mohammed LU and Lindstedt, Sandra LU
- organization
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- aged garlic extract, atherosclerosis, cutaneous microcirculation, double blinded, laser Doppler velocimetry
- in
- International Wound Journal
- volume
- 16
- issue
- 6
- pages
- 1487 - 1493
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85073807225
- pmid:31518044
- ISSN
- 1742-4801
- DOI
- 10.1111/iwj.13220
- project
- Microvascular blood flow measurements with laser speckle contranst imaging in skin, lung and heart
- language
- English
- LU publication?
- yes
- id
- 88cc7ac1-cf1a-45e4-bb14-cf6c62e23622
- date added to LUP
- 2019-11-01 09:50:33
- date last changed
- 2024-09-04 11:46:42
@article{88cc7ac1-cf1a-45e4-bb14-cf6c62e23622, abstract = {{<p>Laser Doppler velocimetry estimates tissue perfusion providing a record of microvascular blood flow. Patients with heart disease or diabetes mellitus have impaired microvascular perfusion leading to impaired wound healing. Aged garlic extract (AGE) has a positive effect on vascular elasticity. This study aimed to assess the effect of long-term treatment with AGE on cutaneous tissue perfusion. A total of 122 patients with Framingham Risk Score ≥ 10 were randomised in a double-blinded manner to placebo or 2400 mg AGE daily for 1 year and monitored. Cutaneous microcirculation was measured at 0 and 12 months using laser Doppler velocimetry. A repeated measures analysis of variance (ANOVA) with a Greenhouse–Geisser correction determined that mean post-occlusive reactive hyperaemia differed significantly between time points. The mean percent change between the two time points 0 and 12 months was 102, 64 (174, 15)% change for AGE and 78, 62 (107, 92)% change for the placebo group (F[1, 120] = 5. 95, P < 0.016), 12 months of AGE increases the microcirculation in patients with an increased risk for cardiovascular events estimated using the Framingham risk score. Increased microcirculation could hypothetically facilitate wound healing.</p>}}, author = {{Wlosinska, Martine and Nilsson, Ann Christin and Hlebowicz, Joanna and Malmsjö, Malin and Fakhro, Mohammed and Lindstedt, Sandra}}, issn = {{1742-4801}}, keywords = {{aged garlic extract; atherosclerosis; cutaneous microcirculation; double blinded; laser Doppler velocimetry}}, language = {{eng}}, number = {{6}}, pages = {{1487--1493}}, publisher = {{Wiley-Blackwell}}, series = {{International Wound Journal}}, title = {{Aged garlic extract preserves cutaneous microcirculation in patients with increased risk for cardiovascular diseases : A double-blinded placebo-controlled study}}, url = {{http://dx.doi.org/10.1111/iwj.13220}}, doi = {{10.1111/iwj.13220}}, volume = {{16}}, year = {{2019}}, }