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Aged garlic extract preserves cutaneous microcirculation in patients with increased risk for cardiovascular diseases : A double-blinded placebo-controlled study

Wlosinska, Martine LU ; Nilsson, Ann Christin LU ; Hlebowicz, Joanna LU ; Malmsjö, Malin LU ; Fakhro, Mohammed LU and Lindstedt, Sandra LU (2019) In International Wound Journal 16(6). p.1487-1493
Abstract

Laser Doppler velocimetry estimates tissue perfusion providing a record of microvascular blood flow. Patients with heart disease or diabetes mellitus have impaired microvascular perfusion leading to impaired wound healing. Aged garlic extract (AGE) has a positive effect on vascular elasticity. This study aimed to assess the effect of long-term treatment with AGE on cutaneous tissue perfusion. A total of 122 patients with Framingham Risk Score ≥ 10 were randomised in a double-blinded manner to placebo or 2400 mg AGE daily for 1 year and monitored. Cutaneous microcirculation was measured at 0 and 12 months using laser Doppler velocimetry. A repeated measures analysis of variance (ANOVA) with a Greenhouse–Geisser correction determined that... (More)

Laser Doppler velocimetry estimates tissue perfusion providing a record of microvascular blood flow. Patients with heart disease or diabetes mellitus have impaired microvascular perfusion leading to impaired wound healing. Aged garlic extract (AGE) has a positive effect on vascular elasticity. This study aimed to assess the effect of long-term treatment with AGE on cutaneous tissue perfusion. A total of 122 patients with Framingham Risk Score ≥ 10 were randomised in a double-blinded manner to placebo or 2400 mg AGE daily for 1 year and monitored. Cutaneous microcirculation was measured at 0 and 12 months using laser Doppler velocimetry. A repeated measures analysis of variance (ANOVA) with a Greenhouse–Geisser correction determined that mean post-occlusive reactive hyperaemia differed significantly between time points. The mean percent change between the two time points 0 and 12 months was 102, 64 (174, 15)% change for AGE and 78, 62 (107, 92)% change for the placebo group (F[1, 120] = 5. 95, P < 0.016), 12 months of AGE increases the microcirculation in patients with an increased risk for cardiovascular events estimated using the Framingham risk score. Increased microcirculation could hypothetically facilitate wound healing.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
aged garlic extract, atherosclerosis, cutaneous microcirculation, double blinded, laser Doppler velocimetry
in
International Wound Journal
volume
16
issue
6
pages
1487 - 1493
publisher
Wiley-Blackwell
external identifiers
  • pmid:31518044
  • scopus:85073807225
ISSN
1742-4801
DOI
10.1111/iwj.13220
project
Microvascular blood flow measurements with laser speckle contranst imaging in skin, lung and heart
language
English
LU publication?
yes
id
88cc7ac1-cf1a-45e4-bb14-cf6c62e23622
date added to LUP
2019-11-01 09:50:33
date last changed
2024-06-26 05:27:33
@article{88cc7ac1-cf1a-45e4-bb14-cf6c62e23622,
  abstract     = {{<p>Laser Doppler velocimetry estimates tissue perfusion providing a record of microvascular blood flow. Patients with heart disease or diabetes mellitus have impaired microvascular perfusion leading to impaired wound healing. Aged garlic extract (AGE) has a positive effect on vascular elasticity. This study aimed to assess the effect of long-term treatment with AGE on cutaneous tissue perfusion. A total of 122 patients with Framingham Risk Score ≥ 10 were randomised in a double-blinded manner to placebo or 2400 mg AGE daily for 1 year and monitored. Cutaneous microcirculation was measured at 0 and 12 months using laser Doppler velocimetry. A repeated measures analysis of variance (ANOVA) with a Greenhouse–Geisser correction determined that mean post-occlusive reactive hyperaemia differed significantly between time points. The mean percent change between the two time points 0 and 12 months was 102, 64 (174, 15)% change for AGE and 78, 62 (107, 92)% change for the placebo group (F[1, 120] = 5. 95, P &lt; 0.016), 12 months of AGE increases the microcirculation in patients with an increased risk for cardiovascular events estimated using the Framingham risk score. Increased microcirculation could hypothetically facilitate wound healing.</p>}},
  author       = {{Wlosinska, Martine and Nilsson, Ann Christin and Hlebowicz, Joanna and Malmsjö, Malin and Fakhro, Mohammed and Lindstedt, Sandra}},
  issn         = {{1742-4801}},
  keywords     = {{aged garlic extract; atherosclerosis; cutaneous microcirculation; double blinded; laser Doppler velocimetry}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{1487--1493}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{International Wound Journal}},
  title        = {{Aged garlic extract preserves cutaneous microcirculation in patients with increased risk for cardiovascular diseases : A double-blinded placebo-controlled study}},
  url          = {{http://dx.doi.org/10.1111/iwj.13220}},
  doi          = {{10.1111/iwj.13220}},
  volume       = {{16}},
  year         = {{2019}},
}