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Longitudinal trajectories of cognitive decline and cerebral blood flow abnormalities in octogenarian men with normal global cognition

Siennicki-Lantz, Arkadiusz LU orcid ; André-Petersson, Lena LU and Elmståhl, Sölve LU (2024) In Cerebral Circulation - Cognition and Behavior 6.
Abstract

Aims: Cognitive and perfusion changes have been previously observed in older men with Mini Mental State Examination scores>24 points. We aimed to investigate time change in cognitive domains in a cohort of non-demented men between age 68 and 82, and how they are expressed in regional defects estimated by Cerebral Blood Flow (rCBF). Methods: 103 men at age 81 with MMSE scores >24 (mean 28.4 ± 1.7), no dementia or stroke, were examined with the same cognitive test battery at age 68 and age 81: Synonyms (SRB-1), Block design (SRB-3), Paired Associates, Digit Symbol Substitution and Benton Visual Retention test. rCBF was estimated using 99mTc-HMPAO SPECT at age 82. Results: Between ages 68 and 82 we observed a relative... (More)

Aims: Cognitive and perfusion changes have been previously observed in older men with Mini Mental State Examination scores>24 points. We aimed to investigate time change in cognitive domains in a cohort of non-demented men between age 68 and 82, and how they are expressed in regional defects estimated by Cerebral Blood Flow (rCBF). Methods: 103 men at age 81 with MMSE scores >24 (mean 28.4 ± 1.7), no dementia or stroke, were examined with the same cognitive test battery at age 68 and age 81: Synonyms (SRB-1), Block design (SRB-3), Paired Associates, Digit Symbol Substitution and Benton Visual Retention test. rCBF was estimated using 99mTc-HMPAO SPECT at age 82. Results: Between ages 68 and 82 we observed a relative decline (Δ%) of cognitive test scores: SRB-3 and Benton tests, -33.7 % (SD 16,8) and -25.8 % (SD 23.9) respectively, followed by Digit Symbol test: -22,6 % (SD 15,6). The cluster of men (46 %) could be detected, grouped on the largest test score decline and highest overall test predictors’ importance in decreasing order: Δ% SRB-3, Δ% Paired Associates, Δ% Digit Symbol, Δ% Benton VR and Δ% SRB-1. Compared to the cluster with stable cognitive functions, it expressed lower rCBF in frontal and parietal lobes, and in subcortical areas. Conclusion: Nearly half of the studied, community-dwelling cohort of non-demented, octogenarian men with MMSE > 24, had a combination of decreasing visuospatial ability and episodic memory during preceding years, expressed by widespread rCBF changes in fronto-subcortical areas.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Aged, 80 and over, Cohort studies, Neuropsychological tests;Tomography, emission-computed, single-photon
in
Cerebral Circulation - Cognition and Behavior
volume
6
article number
100220
publisher
Elsevier
external identifiers
  • pmid:38523604
  • scopus:85187985758
ISSN
2666-2450
DOI
10.1016/j.cccb.2024.100220
language
English
LU publication?
yes
id
88dfa881-7687-43d4-b0c6-c313784415e6
date added to LUP
2024-04-10 11:36:42
date last changed
2024-04-24 14:28:27
@article{88dfa881-7687-43d4-b0c6-c313784415e6,
  abstract     = {{<p>Aims: Cognitive and perfusion changes have been previously observed in older men with Mini Mental State Examination scores&gt;24 points. We aimed to investigate time change in cognitive domains in a cohort of non-demented men between age 68 and 82, and how they are expressed in regional defects estimated by Cerebral Blood Flow (rCBF). Methods: 103 men at age 81 with MMSE scores &gt;24 (mean 28.4 ± 1.7), no dementia or stroke, were examined with the same cognitive test battery at age 68 and age 81: Synonyms (SRB-1), Block design (SRB-3), Paired Associates, Digit Symbol Substitution and Benton Visual Retention test. rCBF was estimated using <sup>99mTc</sup>-HMPAO SPECT at age 82. Results: Between ages 68 and 82 we observed a relative decline (Δ%) of cognitive test scores: SRB-3 and Benton tests, -33.7 % (SD 16,8) and -25.8 % (SD 23.9) respectively, followed by Digit Symbol test: -22,6 % (SD 15,6). The cluster of men (46 %) could be detected, grouped on the largest test score decline and highest overall test predictors’ importance in decreasing order: Δ% SRB-3, Δ% Paired Associates, Δ% Digit Symbol, Δ% Benton VR and Δ% SRB-1. Compared to the cluster with stable cognitive functions, it expressed lower rCBF in frontal and parietal lobes, and in subcortical areas. Conclusion: Nearly half of the studied, community-dwelling cohort of non-demented, octogenarian men with MMSE &gt; 24, had a combination of decreasing visuospatial ability and episodic memory during preceding years, expressed by widespread rCBF changes in fronto-subcortical areas.</p>}},
  author       = {{Siennicki-Lantz, Arkadiusz and André-Petersson, Lena and Elmståhl, Sölve}},
  issn         = {{2666-2450}},
  keywords     = {{Aged, 80 and over; Cohort studies; Neuropsychological tests;Tomography, emission-computed, single-photon}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{Cerebral Circulation - Cognition and Behavior}},
  title        = {{Longitudinal trajectories of cognitive decline and cerebral blood flow abnormalities in octogenarian men with normal global cognition}},
  url          = {{http://dx.doi.org/10.1016/j.cccb.2024.100220}},
  doi          = {{10.1016/j.cccb.2024.100220}},
  volume       = {{6}},
  year         = {{2024}},
}