Advanced

Familial and second lung cancers : a nation-wide epidemiologic study from Sweden

Li, Xinjun LU and Hemminki, Kari LU (2003) In Lung Cancer 39(3). p.63-255
Abstract

The role of hereditary factors in tumor development has been less well understood for lung cancer than for many other human neoplastic diseases. The nation-wide Swedish Family-Cancer Database was used on 10.2 million individuals and 4524 lung cancers to calculate standardized incidence ratios (SIRs) and 95% confidence intervals (CIs) for histological subtypes of lung cancer in 0-66-year-old offspring by cancers in family members. Additionally, SIRs for second lung cancers were analyzed. SIRs in offspring for all lung cancer were increased to 1.87 (95% CI 1.66-2.10), adenocarcinoma to 2.15 (1.77-2.59) and squamous cell carcinoma to 1.86 (1.39-2.44) when a parent presented with lung cancer. The familial risk was not dependent on... (More)

The role of hereditary factors in tumor development has been less well understood for lung cancer than for many other human neoplastic diseases. The nation-wide Swedish Family-Cancer Database was used on 10.2 million individuals and 4524 lung cancers to calculate standardized incidence ratios (SIRs) and 95% confidence intervals (CIs) for histological subtypes of lung cancer in 0-66-year-old offspring by cancers in family members. Additionally, SIRs for second lung cancers were analyzed. SIRs in offspring for all lung cancer were increased to 1.87 (95% CI 1.66-2.10), adenocarcinoma to 2.15 (1.77-2.59) and squamous cell carcinoma to 1.86 (1.39-2.44) when a parent presented with lung cancer. The familial risk was not dependent on diagnostic age. Lung cancer associated with parental rectal, cervical, kidney, urinary bladder and endocrine gland cancer. The population attributable fraction of familial lung cancer was 2.97%. Risks for second lung cancers were increased in men and women after smoking and life style related sites, and after skin cancer, non-Hodgkin's lymphoma and Hodgkin's disease.

(Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adolescent, Adult, Age of Onset, Aged, Child, Child, Preschool, Databases, Factual, Epidemiologic Studies, Female, Genetic Predisposition to Disease, Humans, Infant, Infant, Newborn, Life Style, Lung Neoplasms/epidemiology, Male, Middle Aged, Neoplasms, Second Primary/epidemiology, Registries/statistics & numerical data, Risk Factors, Smoking, Sweden/epidemiology
in
Lung Cancer
volume
39
issue
3
pages
9 pages
publisher
Elsevier
external identifiers
  • scopus:0037373666
ISSN
0169-5002
DOI
10.1016/S0169-5002(02)00535-4
language
English
LU publication?
no
id
890328fa-3b94-4cfa-8da8-59c8a3372b18
date added to LUP
2019-01-30 12:06:01
date last changed
2019-02-27 05:11:34
@article{890328fa-3b94-4cfa-8da8-59c8a3372b18,
  abstract     = {<p>The role of hereditary factors in tumor development has been less well understood for lung cancer than for many other human neoplastic diseases. The nation-wide Swedish Family-Cancer Database was used on 10.2 million individuals and 4524 lung cancers to calculate standardized incidence ratios (SIRs) and 95% confidence intervals (CIs) for histological subtypes of lung cancer in 0-66-year-old offspring by cancers in family members. Additionally, SIRs for second lung cancers were analyzed. SIRs in offspring for all lung cancer were increased to 1.87 (95% CI 1.66-2.10), adenocarcinoma to 2.15 (1.77-2.59) and squamous cell carcinoma to 1.86 (1.39-2.44) when a parent presented with lung cancer. The familial risk was not dependent on diagnostic age. Lung cancer associated with parental rectal, cervical, kidney, urinary bladder and endocrine gland cancer. The population attributable fraction of familial lung cancer was 2.97%. Risks for second lung cancers were increased in men and women after smoking and life style related sites, and after skin cancer, non-Hodgkin's lymphoma and Hodgkin's disease.</p>},
  author       = {Li, Xinjun and Hemminki, Kari},
  issn         = {0169-5002},
  keyword      = {Adolescent,Adult,Age of Onset,Aged,Child,Child, Preschool,Databases, Factual,Epidemiologic Studies,Female,Genetic Predisposition to Disease,Humans,Infant,Infant, Newborn,Life Style,Lung Neoplasms/epidemiology,Male,Middle Aged,Neoplasms, Second Primary/epidemiology,Registries/statistics & numerical data,Risk Factors,Smoking,Sweden/epidemiology},
  language     = {eng},
  number       = {3},
  pages        = {63--255},
  publisher    = {Elsevier},
  series       = {Lung Cancer},
  title        = {Familial and second lung cancers : a nation-wide epidemiologic study from Sweden},
  url          = {http://dx.doi.org/10.1016/S0169-5002(02)00535-4},
  volume       = {39},
  year         = {2003},
}