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The Bystander Effect : Mesenchymal Stem Cell-Mediated Lung Repair

Blank Savukinas, Ulrika LU ; Rolandsson Enes, Sara LU ; Andersson Sjöland, Annika LU and Westergren-Thorsson, Gunilla LU (2016) In Stem Cells 34(6). p.1437-1444
Abstract
Mesenchymal stem or stromal cells (MSCs), a heterogeneous subset of adult stem/progenitor cells, have surfaced as potential therapeutic units with significant clinical benefit for a wide spectrum of disease conditions, including those affecting the lung. Although MSCs carry both self-renewal and multilineage differentiation abilities, current dogma holds that MSCs mainly contribute to tissue regeneration and repair by modulating the host tissue via secreted cues. Thus, the therapeutic benefit of MSCs is thought to derive from so called bystander effects. The regenerative mechanisms employed by MSCs in the lung include modulation of the immune system as well as promotion of epithelial and endothelial repair. Apart from secreted factors, a... (More)
Mesenchymal stem or stromal cells (MSCs), a heterogeneous subset of adult stem/progenitor cells, have surfaced as potential therapeutic units with significant clinical benefit for a wide spectrum of disease conditions, including those affecting the lung. Although MSCs carry both self-renewal and multilineage differentiation abilities, current dogma holds that MSCs mainly contribute to tissue regeneration and repair by modulating the host tissue via secreted cues. Thus, the therapeutic benefit of MSCs is thought to derive from so called bystander effects. The regenerative mechanisms employed by MSCs in the lung include modulation of the immune system as well as promotion of epithelial and endothelial repair. Apart from secreted factors, a number of recent findings suggest that MSCs engage in mitochondrial transfer and shedding of membrane vesicles as a means to enhance tissue repair following injury. Furthermore, it is becoming increasingly clear that MSCs are an integral component of epithelial lung stem cell niches. As such, MSCs play an important role in coupling information from the environment to stem and progenitor populations, such that homeostasis can be ensured even in the face of injury. It is the aim of this review to outline the major mechanisms by which MSCs contribute to lung regeneration, synthesizing recent preclinical findings with data from clinical trials and potential for future therapy (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Lung, Mesenchymal stem cell, Paracrine communication, Regenerative medicine, Stem cell niche, Immunomodulation
in
Stem Cells
volume
34
issue
6
pages
1437 - 1444
publisher
AlphaMed Press
external identifiers
  • scopus:84963652558
ISSN
1549-4918
DOI
10.1002/stem.2357
language
English
LU publication?
yes
id
8903be80-0ff6-49d0-9ab9-67b2b5fc56f6
date added to LUP
2016-05-20 15:15:49
date last changed
2017-06-29 14:43:45
@article{8903be80-0ff6-49d0-9ab9-67b2b5fc56f6,
  abstract     = {Mesenchymal stem or stromal cells (MSCs), a heterogeneous subset of adult stem/progenitor cells, have surfaced as potential therapeutic units with significant clinical benefit for a wide spectrum of disease conditions, including those affecting the lung. Although MSCs carry both self-renewal and multilineage differentiation abilities, current dogma holds that MSCs mainly contribute to tissue regeneration and repair by modulating the host tissue via secreted cues. Thus, the therapeutic benefit of MSCs is thought to derive from so called bystander effects. The regenerative mechanisms employed by MSCs in the lung include modulation of the immune system as well as promotion of epithelial and endothelial repair. Apart from secreted factors, a number of recent findings suggest that MSCs engage in mitochondrial transfer and shedding of membrane vesicles as a means to enhance tissue repair following injury. Furthermore, it is becoming increasingly clear that MSCs are an integral component of epithelial lung stem cell niches. As such, MSCs play an important role in coupling information from the environment to stem and progenitor populations, such that homeostasis can be ensured even in the face of injury. It is the aim of this review to outline the major mechanisms by which MSCs contribute to lung regeneration, synthesizing recent preclinical findings with data from clinical trials and potential for future therapy},
  author       = {Blank Savukinas, Ulrika and Rolandsson Enes, Sara and Andersson Sjöland, Annika and Westergren-Thorsson, Gunilla},
  issn         = {1549-4918},
  keyword      = {Lung,Mesenchymal stem cell,Paracrine communication,Regenerative medicine,Stem cell niche,Immunomodulation},
  language     = {eng},
  month        = {03},
  number       = {6},
  pages        = {1437--1444},
  publisher    = {AlphaMed Press},
  series       = {Stem Cells},
  title        = {The Bystander Effect : Mesenchymal Stem Cell-Mediated Lung Repair},
  url          = {http://dx.doi.org/10.1002/stem.2357},
  volume       = {34},
  year         = {2016},
}