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Accuracy of the quantification of organ activity from planar gamma camera images

Norrgren, Kristina LU ; Svegborn, SL; Areberg, Johan LU and Mattsson, Sören LU (2003) In Cancer Biotherapy & Radiopharmaceuticals 18(1). p.125-131
Abstract
The accuracy in determination of organ activity of Tc-99m was investigated, with activity estimated from gamma camera images of phantoms, using the, conjugate view method. The accuracy depends on several parameters such as the choice of background correction method, the accuracy in determination of the effective attenuation coefficient and the thickness of the body and organs and on the determination of the gamma camera sensitivity. The background correction method has a major influence on the quantification of the activity. Methods which take the volume of the source organ into consideration are recommended The discrepancy in the determined organ activity varied between an underestimation of 26% and an overestimation of 16% in the MIRD... (More)
The accuracy in determination of organ activity of Tc-99m was investigated, with activity estimated from gamma camera images of phantoms, using the, conjugate view method. The accuracy depends on several parameters such as the choice of background correction method, the accuracy in determination of the effective attenuation coefficient and the thickness of the body and organs and on the determination of the gamma camera sensitivity. The background correction method has a major influence on the quantification of the activity. Methods which take the volume of the source organ into consideration are recommended The discrepancy in the determined organ activity varied between an underestimation of 26% and an overestimation of 16% in the MIRD phantom, depending on which organ was studied and on the correction method used To correct for absorption and scattering, an effective attenuation coefficient was used. A theoretical analysis showed that a change in the effective attenuation coefficient of 0.01 cm(-1) resulted in a 15% change in the calculated activity. Also the thickness of the body and the organ of interest influences the calculated activity. A 2 cm deviation in the body thickness causes a deviation of approximately 10% in the calculated activity. The quantification is improved if the attenuation coefficient is determined by transmission measurements. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cancer Biotherapy & Radiopharmaceuticals
volume
18
issue
1
pages
125 - 131
publisher
Mary Ann Liebert, Inc.
external identifiers
  • wos:000181441400014
  • pmid:12667315
  • scopus:0037219491
ISSN
1557-8852
DOI
10.1089/108497803321269403.
language
English
LU publication?
yes
id
2a111a5f-2fc2-48d7-8845-635d5b57ce29 (old id 890995)
date added to LUP
2008-01-15 09:22:00
date last changed
2018-07-22 03:58:51
@article{2a111a5f-2fc2-48d7-8845-635d5b57ce29,
  abstract     = {The accuracy in determination of organ activity of Tc-99m was investigated, with activity estimated from gamma camera images of phantoms, using the, conjugate view method. The accuracy depends on several parameters such as the choice of background correction method, the accuracy in determination of the effective attenuation coefficient and the thickness of the body and organs and on the determination of the gamma camera sensitivity. The background correction method has a major influence on the quantification of the activity. Methods which take the volume of the source organ into consideration are recommended The discrepancy in the determined organ activity varied between an underestimation of 26% and an overestimation of 16% in the MIRD phantom, depending on which organ was studied and on the correction method used To correct for absorption and scattering, an effective attenuation coefficient was used. A theoretical analysis showed that a change in the effective attenuation coefficient of 0.01 cm(-1) resulted in a 15% change in the calculated activity. Also the thickness of the body and the organ of interest influences the calculated activity. A 2 cm deviation in the body thickness causes a deviation of approximately 10% in the calculated activity. The quantification is improved if the attenuation coefficient is determined by transmission measurements.},
  author       = {Norrgren, Kristina and Svegborn, SL and Areberg, Johan and Mattsson, Sören},
  issn         = {1557-8852},
  language     = {eng},
  number       = {1},
  pages        = {125--131},
  publisher    = {Mary Ann Liebert, Inc.},
  series       = {Cancer Biotherapy & Radiopharmaceuticals},
  title        = {Accuracy of the quantification of organ activity from planar gamma camera images},
  url          = {http://dx.doi.org/10.1089/108497803321269403.},
  volume       = {18},
  year         = {2003},
}