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Fecundability according to male serum inhibin B - a prospective study among first pregnancy planners

Mabeck, LM; Jensen, MS; Toft, G; Thulstrup, M; Andersson, M; Jensen, TK; Giwercman, Aleksander LU ; Olsen, J and Bonde, JP (2005) In Human Reproduction 20(10). p.2909-2915
Abstract
BACKGROUND: New biological markers of male fecundity are needed for use in large-scale epidemiological studies. We studied the association between male inhibin B and fecundability. METHODS: Four hundred and thirty Danish couples without previous reproductive experience were followed from termination of contraception until pregnancy or for a maximum of six menstrual cycles. At enrolment we obtained semen samples (n = 418) and blood samples to measure reproductive hormones, including inhibin B (n = 343). RESULTS: The fecundability odds ratio for an increment of male inhibin B by 1 log pg/ml was 1.428 (95% confidence interval 1.022-1.994), adjusted for factors influencing the crude estimate. Only inhibin B values below 100 pg/ml were strongly... (More)
BACKGROUND: New biological markers of male fecundity are needed for use in large-scale epidemiological studies. We studied the association between male inhibin B and fecundability. METHODS: Four hundred and thirty Danish couples without previous reproductive experience were followed from termination of contraception until pregnancy or for a maximum of six menstrual cycles. At enrolment we obtained semen samples (n = 418) and blood samples to measure reproductive hormones, including inhibin B (n = 343). RESULTS: The fecundability odds ratio for an increment of male inhibin B by 1 log pg/ml was 1.428 (95% confidence interval 1.022-1.994), adjusted for factors influencing the crude estimate. Only inhibin B values below 100 pg/ml were strongly related to fecundability. We designed a receiver operating characteristic curve based on the 29 males with serum inhibin B <= 100 pg/ml. The area under the curve (AUC) for inhibin B was 0.787 and the corresponding AUCs for sperm density and FSH were 0.913 and 0.800, respectively. CONCLUSION: Serum inhibin B may be a reliable marker of male fecundity for epidemiological research and may have some advantages over sperm density. Our findings do not support the replacement of sperm density by male inhibin B when obtaining sperm data is an option. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
inhibins, fertility, male reproduction, sperm density, time to pregnancy
in
Human Reproduction
volume
20
issue
10
pages
2909 - 2915
publisher
Oxford University Press
external identifiers
  • pmid:16024538
  • wos:000232427600036
  • scopus:27144546958
ISSN
0268-1161
DOI
10.1093/humrep/dei141
language
English
LU publication?
yes
id
f044bf19-2ea7-4b28-8187-b4e42d03e15d (old id 891472)
date added to LUP
2008-01-16 13:55:46
date last changed
2017-01-01 04:45:26
@article{f044bf19-2ea7-4b28-8187-b4e42d03e15d,
  abstract     = {BACKGROUND: New biological markers of male fecundity are needed for use in large-scale epidemiological studies. We studied the association between male inhibin B and fecundability. METHODS: Four hundred and thirty Danish couples without previous reproductive experience were followed from termination of contraception until pregnancy or for a maximum of six menstrual cycles. At enrolment we obtained semen samples (n = 418) and blood samples to measure reproductive hormones, including inhibin B (n = 343). RESULTS: The fecundability odds ratio for an increment of male inhibin B by 1 log pg/ml was 1.428 (95% confidence interval 1.022-1.994), adjusted for factors influencing the crude estimate. Only inhibin B values below 100 pg/ml were strongly related to fecundability. We designed a receiver operating characteristic curve based on the 29 males with serum inhibin B &lt;= 100 pg/ml. The area under the curve (AUC) for inhibin B was 0.787 and the corresponding AUCs for sperm density and FSH were 0.913 and 0.800, respectively. CONCLUSION: Serum inhibin B may be a reliable marker of male fecundity for epidemiological research and may have some advantages over sperm density. Our findings do not support the replacement of sperm density by male inhibin B when obtaining sperm data is an option.},
  author       = {Mabeck, LM and Jensen, MS and Toft, G and Thulstrup, M and Andersson, M and Jensen, TK and Giwercman, Aleksander and Olsen, J and Bonde, JP},
  issn         = {0268-1161},
  keyword      = {inhibins,fertility,male reproduction,sperm density,time to pregnancy},
  language     = {eng},
  number       = {10},
  pages        = {2909--2915},
  publisher    = {Oxford University Press},
  series       = {Human Reproduction},
  title        = {Fecundability according to male serum inhibin B - a prospective study among first pregnancy planners},
  url          = {http://dx.doi.org/10.1093/humrep/dei141},
  volume       = {20},
  year         = {2005},
}