Cerebrospinal fluid levels of biomarkers and activity of acetylcholinesterase (AChE) and butyrylcholinesterase in AD patients before and after treatment with different AChE inhibitors
(2002) In Neurological Sciences 23. p.95-96- Abstract
- In order to evaluate the biochemical effects of long-term treatment with inhibitors of acetylcholinesterase (AChE) in patients with Alzheimer's disease (AD), we measured the activities of AChE and butyry1cholinesterase (BuChe) and the concentrations of beta-amyloid (1-42), tau and phosphorylated tau proteins in the cerebrospinal fluid (CSF). A total of 91 patients suffering from probable AD of mild to moderate degree were treated for 6 months with donepezil (n=59), galantamine (n=15), rivastigmine (n=10), or placebo (n=7). AChE activity in CSF was significantly increased after treatment with donepezil and galantamine; the opposite was observed in the rivastigmine-treated group. Untreated patients did not show any AChE activity variation.... (More)
- In order to evaluate the biochemical effects of long-term treatment with inhibitors of acetylcholinesterase (AChE) in patients with Alzheimer's disease (AD), we measured the activities of AChE and butyry1cholinesterase (BuChe) and the concentrations of beta-amyloid (1-42), tau and phosphorylated tau proteins in the cerebrospinal fluid (CSF). A total of 91 patients suffering from probable AD of mild to moderate degree were treated for 6 months with donepezil (n=59), galantamine (n=15), rivastigmine (n=10), or placebo (n=7). AChE activity in CSF was significantly increased after treatment with donepezil and galantamine; the opposite was observed in the rivastigmine-treated group. Untreated patients did not show any AChE activity variation. BuChE did not show any change in any of the groups studied. Mean values of beta-amyloid(1-42), total tau and phosphorylated tau also did not vary significantly. We conclude that AChE inhibitors induce different effects on CSF AChE activity, while other CSF biomarkers are not significantly affected by treatment. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/892350
- author
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Neurological Sciences
- volume
- 23
- pages
- 95 - 96
- publisher
- Springer
- external identifiers
-
- wos:000179317800023
- scopus:18744417222
- pmid:12548360
- ISSN
- 1590-1874
- DOI
- 10.1007/s100720200086
- language
- English
- LU publication?
- yes
- id
- 101eb529-6729-4d7b-ad61-6493d62103cf (old id 892350)
- date added to LUP
- 2016-04-01 12:34:24
- date last changed
- 2022-03-29 02:41:08
@article{101eb529-6729-4d7b-ad61-6493d62103cf, abstract = {{In order to evaluate the biochemical effects of long-term treatment with inhibitors of acetylcholinesterase (AChE) in patients with Alzheimer's disease (AD), we measured the activities of AChE and butyry1cholinesterase (BuChe) and the concentrations of beta-amyloid (1-42), tau and phosphorylated tau proteins in the cerebrospinal fluid (CSF). A total of 91 patients suffering from probable AD of mild to moderate degree were treated for 6 months with donepezil (n=59), galantamine (n=15), rivastigmine (n=10), or placebo (n=7). AChE activity in CSF was significantly increased after treatment with donepezil and galantamine; the opposite was observed in the rivastigmine-treated group. Untreated patients did not show any AChE activity variation. BuChE did not show any change in any of the groups studied. Mean values of beta-amyloid(1-42), total tau and phosphorylated tau also did not vary significantly. We conclude that AChE inhibitors induce different effects on CSF AChE activity, while other CSF biomarkers are not significantly affected by treatment.}}, author = {{Parnetti, L and Amici, S and Lanari, A and Romani, C and Antognelli, C and Andreasen, N and Minthon, Lennart and Davidsson, P and Pottel, H and Blennow, K and Gallai, V}}, issn = {{1590-1874}}, language = {{eng}}, pages = {{95--96}}, publisher = {{Springer}}, series = {{Neurological Sciences}}, title = {{Cerebrospinal fluid levels of biomarkers and activity of acetylcholinesterase (AChE) and butyrylcholinesterase in AD patients before and after treatment with different AChE inhibitors}}, url = {{http://dx.doi.org/10.1007/s100720200086}}, doi = {{10.1007/s100720200086}}, volume = {{23}}, year = {{2002}}, }