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Cerebrospinal fluid levels of biomarkers and activity of acetylcholinesterase (AChE) and butyrylcholinesterase in AD patients before and after treatment with different AChE inhibitors

Parnetti, L; Amici, S; Lanari, A; Romani, C; Antognelli, C; Andreasen, N; Minthon, Lennart LU ; Davidsson, P; Pottel, H and Blennow, K, et al. (2002) In Neurological Sciences 23. p.95-96
Abstract
In order to evaluate the biochemical effects of long-term treatment with inhibitors of acetylcholinesterase (AChE) in patients with Alzheimer's disease (AD), we measured the activities of AChE and butyry1cholinesterase (BuChe) and the concentrations of beta-amyloid (1-42), tau and phosphorylated tau proteins in the cerebrospinal fluid (CSF). A total of 91 patients suffering from probable AD of mild to moderate degree were treated for 6 months with donepezil (n=59), galantamine (n=15), rivastigmine (n=10), or placebo (n=7). AChE activity in CSF was significantly increased after treatment with donepezil and galantamine; the opposite was observed in the rivastigmine-treated group. Untreated patients did not show any AChE activity variation.... (More)
In order to evaluate the biochemical effects of long-term treatment with inhibitors of acetylcholinesterase (AChE) in patients with Alzheimer's disease (AD), we measured the activities of AChE and butyry1cholinesterase (BuChe) and the concentrations of beta-amyloid (1-42), tau and phosphorylated tau proteins in the cerebrospinal fluid (CSF). A total of 91 patients suffering from probable AD of mild to moderate degree were treated for 6 months with donepezil (n=59), galantamine (n=15), rivastigmine (n=10), or placebo (n=7). AChE activity in CSF was significantly increased after treatment with donepezil and galantamine; the opposite was observed in the rivastigmine-treated group. Untreated patients did not show any AChE activity variation. BuChE did not show any change in any of the groups studied. Mean values of beta-amyloid(1-42), total tau and phosphorylated tau also did not vary significantly. We conclude that AChE inhibitors induce different effects on CSF AChE activity, while other CSF biomarkers are not significantly affected by treatment. (Less)
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publication status
published
subject
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Neurological Sciences
volume
23
pages
95 - 96
publisher
Springer
external identifiers
  • wos:000179317800023
  • scopus:18744417222
ISSN
1590-1874
DOI
10.1007/s100720200086
language
English
LU publication?
yes
id
101eb529-6729-4d7b-ad61-6493d62103cf (old id 892350)
date added to LUP
2008-01-23 22:30:00
date last changed
2017-04-16 03:41:27
@article{101eb529-6729-4d7b-ad61-6493d62103cf,
  abstract     = {In order to evaluate the biochemical effects of long-term treatment with inhibitors of acetylcholinesterase (AChE) in patients with Alzheimer's disease (AD), we measured the activities of AChE and butyry1cholinesterase (BuChe) and the concentrations of beta-amyloid (1-42), tau and phosphorylated tau proteins in the cerebrospinal fluid (CSF). A total of 91 patients suffering from probable AD of mild to moderate degree were treated for 6 months with donepezil (n=59), galantamine (n=15), rivastigmine (n=10), or placebo (n=7). AChE activity in CSF was significantly increased after treatment with donepezil and galantamine; the opposite was observed in the rivastigmine-treated group. Untreated patients did not show any AChE activity variation. BuChE did not show any change in any of the groups studied. Mean values of beta-amyloid(1-42), total tau and phosphorylated tau also did not vary significantly. We conclude that AChE inhibitors induce different effects on CSF AChE activity, while other CSF biomarkers are not significantly affected by treatment.},
  author       = {Parnetti, L and Amici, S and Lanari, A and Romani, C and Antognelli, C and Andreasen, N and Minthon, Lennart and Davidsson, P and Pottel, H and Blennow, K and Gallai, V},
  issn         = {1590-1874},
  language     = {eng},
  pages        = {95--96},
  publisher    = {Springer},
  series       = {Neurological Sciences},
  title        = {Cerebrospinal fluid levels of biomarkers and activity of acetylcholinesterase (AChE) and butyrylcholinesterase in AD patients before and after treatment with different AChE inhibitors},
  url          = {http://dx.doi.org/10.1007/s100720200086},
  volume       = {23},
  year         = {2002},
}