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Uncertain future of trials in osteoporosis

Kanis, JA; Oden, A; Johnell, Olof LU ; Caulin, F; Bone, H; Alexandre, JM; Abadie, E and Lekkerkerker, F (2002) In Osteoporosis International 13(6). p.443-449
Abstract
The advent of effective agents for the treatment of osteoporosis has led to the view that placebo-controlled trials to test new agents for efficacy are no longer appropriate since proven treatments are available. In this review we argue that, if new agents are to be developed, there is still a place for the placebo-controlled trial. A move to studies of equivalence or non-inferiority raises more problems than it resolves.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
drug treatment, fracture, placebo-controlled trials, medical ethics, comparator studies
in
Osteoporosis International
volume
13
issue
6
pages
443 - 449
publisher
Springer
external identifiers
  • wos:000176689600001
  • pmid:12107656
  • scopus:0036303922
ISSN
1433-2965
DOI
10.1007/s001980200052
language
English
LU publication?
yes
id
b8e20675-a9ce-4c87-919b-73119ec2bc05 (old id 893031)
date added to LUP
2008-01-23 16:52:42
date last changed
2017-10-01 04:42:58
@article{b8e20675-a9ce-4c87-919b-73119ec2bc05,
  abstract     = {The advent of effective agents for the treatment of osteoporosis has led to the view that placebo-controlled trials to test new agents for efficacy are no longer appropriate since proven treatments are available. In this review we argue that, if new agents are to be developed, there is still a place for the placebo-controlled trial. A move to studies of equivalence or non-inferiority raises more problems than it resolves.},
  author       = {Kanis, JA and Oden, A and Johnell, Olof and Caulin, F and Bone, H and Alexandre, JM and Abadie, E and Lekkerkerker, F},
  issn         = {1433-2965},
  keyword      = {drug treatment,fracture,placebo-controlled trials,medical ethics,comparator studies},
  language     = {eng},
  number       = {6},
  pages        = {443--449},
  publisher    = {Springer},
  series       = {Osteoporosis International},
  title        = {Uncertain future of trials in osteoporosis},
  url          = {http://dx.doi.org/10.1007/s001980200052},
  volume       = {13},
  year         = {2002},
}