Uncertain future of trials in osteoporosis
(2002) In Osteoporosis International 13(6). p.443-449- Abstract
- The advent of effective agents for the treatment of osteoporosis has led to the view that placebo-controlled trials to test new agents for efficacy are no longer appropriate since proven treatments are available. In this review we argue that, if new agents are to be developed, there is still a place for the placebo-controlled trial. A move to studies of equivalence or non-inferiority raises more problems than it resolves.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/893031
- author
- Kanis, JA ; Oden, A ; Johnell, Olof LU ; Caulin, F ; Bone, H ; Alexandre, JM ; Abadie, E and Lekkerkerker, F
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- drug treatment, fracture, placebo-controlled trials, medical ethics, comparator studies
- in
- Osteoporosis International
- volume
- 13
- issue
- 6
- pages
- 443 - 449
- publisher
- Springer
- external identifiers
-
- wos:000176689600001
- pmid:12107656
- scopus:0036303922
- ISSN
- 1433-2965
- DOI
- 10.1007/s001980200052
- language
- English
- LU publication?
- yes
- id
- b8e20675-a9ce-4c87-919b-73119ec2bc05 (old id 893031)
- date added to LUP
- 2016-04-01 16:15:42
- date last changed
- 2024-01-11 04:48:38
@article{b8e20675-a9ce-4c87-919b-73119ec2bc05, abstract = {{The advent of effective agents for the treatment of osteoporosis has led to the view that placebo-controlled trials to test new agents for efficacy are no longer appropriate since proven treatments are available. In this review we argue that, if new agents are to be developed, there is still a place for the placebo-controlled trial. A move to studies of equivalence or non-inferiority raises more problems than it resolves.}}, author = {{Kanis, JA and Oden, A and Johnell, Olof and Caulin, F and Bone, H and Alexandre, JM and Abadie, E and Lekkerkerker, F}}, issn = {{1433-2965}}, keywords = {{drug treatment; fracture; placebo-controlled trials; medical ethics; comparator studies}}, language = {{eng}}, number = {{6}}, pages = {{443--449}}, publisher = {{Springer}}, series = {{Osteoporosis International}}, title = {{Uncertain future of trials in osteoporosis}}, url = {{http://dx.doi.org/10.1007/s001980200052}}, doi = {{10.1007/s001980200052}}, volume = {{13}}, year = {{2002}}, }