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Active tuberculosis in Africa is associated with reduced Th1 and increased Th2 activity in vivo

Lienhardt, C; Azzurri, A; Amedei, A; Fielding, K; Sillah, J; Sow, OY; Bah, B; Benagiano, M; Diallo, A and Manetti, R, et al. (2002) In European Journal of Immunology 32(6). p.1605-1613
Abstract
Activation of Th1 lymphocytes, IFN-gamma production and macrophage activation are crucial in defense against Mycobacteria. In developing countries, Th2 activation and IL-4 production have been associated in vitro with tuberculosis and with poor clinical outcome after treatment. Serological markers of Th1 [soluble lymphocyte activation gene (LAG)-3] and Th2 (IgE, soluble CD30, and CCL22/macrophage-derived chemokine) activity were measured in 414 HIV-negative tuberculosis patients from The Gambia and Guinee and in 414 healthy household and community controls. Measurements were repeated during treatment to assess the effect of therapy on Th1/Th2 ratio. At diagnosis, sLAG-3 levels were lower in patients than in community controls... (More)
Activation of Th1 lymphocytes, IFN-gamma production and macrophage activation are crucial in defense against Mycobacteria. In developing countries, Th2 activation and IL-4 production have been associated in vitro with tuberculosis and with poor clinical outcome after treatment. Serological markers of Th1 [soluble lymphocyte activation gene (LAG)-3] and Th2 (IgE, soluble CD30, and CCL22/macrophage-derived chemokine) activity were measured in 414 HIV-negative tuberculosis patients from The Gambia and Guinee and in 414 healthy household and community controls. Measurements were repeated during treatment to assess the effect of therapy on Th1/Th2 ratio. At diagnosis, sLAG-3 levels were lower in patients than in community controls (p<0.0001), but were higher in household controls exposed to contact with patients than in community controls (p<0.0001). In comparison with community controls, patients had consistently higher levels of IgE, sCD30, and CCL22 (p<0.0001), whereas household controls had lower levels of indicators of Th2 activity (P<0.0001). After treatment, cured patients had higher levels of Th1 (p<0.0001) and lower levels of Th2 (p<0.0001) activity than patients who were not successfully treated or interrupted therapy. In Africa, tuberculosis is associated with low Th1 and high Th2 activity in vivo, whereas close exposure to tuberculosis is associated with a high Th1/Th2 ratio. Patients with favorable outcome after treatment exhibit a higher Th1/Th2 ratio compared to patients with poor clinical outcome. (Less)
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publication status
published
subject
keywords
tuberculosis, Th1/Th2 activity, lymphocyte activation gene-3 (LAG-3), soluble CD30, IgE
in
European Journal of Immunology
volume
32
issue
6
pages
1605 - 1613
publisher
John Wiley & Sons
external identifiers
  • wos:000176269000011
  • pmid:12115643
  • scopus:0036087252
ISSN
1521-4141
DOI
10.1002/1521-4141(200206)32:6<1605::AID-IMMU1605>3.0.CO;2-6
language
English
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yes
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5302a395-0140-4bc2-ae32-47ea467ff646 (old id 893082)
date added to LUP
2008-01-23 17:22:06
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2017-08-27 03:58:49
@article{5302a395-0140-4bc2-ae32-47ea467ff646,
  abstract     = {Activation of Th1 lymphocytes, IFN-gamma production and macrophage activation are crucial in defense against Mycobacteria. In developing countries, Th2 activation and IL-4 production have been associated in vitro with tuberculosis and with poor clinical outcome after treatment. Serological markers of Th1 [soluble lymphocyte activation gene (LAG)-3] and Th2 (IgE, soluble CD30, and CCL22/macrophage-derived chemokine) activity were measured in 414 HIV-negative tuberculosis patients from The Gambia and Guinee and in 414 healthy household and community controls. Measurements were repeated during treatment to assess the effect of therapy on Th1/Th2 ratio. At diagnosis, sLAG-3 levels were lower in patients than in community controls (p&lt;0.0001), but were higher in household controls exposed to contact with patients than in community controls (p&lt;0.0001). In comparison with community controls, patients had consistently higher levels of IgE, sCD30, and CCL22 (p&lt;0.0001), whereas household controls had lower levels of indicators of Th2 activity (P&lt;0.0001). After treatment, cured patients had higher levels of Th1 (p&lt;0.0001) and lower levels of Th2 (p&lt;0.0001) activity than patients who were not successfully treated or interrupted therapy. In Africa, tuberculosis is associated with low Th1 and high Th2 activity in vivo, whereas close exposure to tuberculosis is associated with a high Th1/Th2 ratio. Patients with favorable outcome after treatment exhibit a higher Th1/Th2 ratio compared to patients with poor clinical outcome.},
  author       = {Lienhardt, C and Azzurri, A and Amedei, A and Fielding, K and Sillah, J and Sow, OY and Bah, B and Benagiano, M and Diallo, A and Manetti, R and Manneh, K and Gustafson, Per and Bennett, S and D'Elios, MM and McAdam, K and Del Prete, G},
  issn         = {1521-4141},
  keyword      = {tuberculosis,Th1/Th2 activity,lymphocyte activation gene-3 (LAG-3),soluble CD30,IgE},
  language     = {eng},
  number       = {6},
  pages        = {1605--1613},
  publisher    = {John Wiley & Sons},
  series       = {European Journal of Immunology},
  title        = {Active tuberculosis in Africa is associated with reduced Th1 and increased Th2 activity in vivo},
  url          = {http://dx.doi.org/10.1002/1521-4141(200206)32:6<1605::AID-IMMU1605>3.0.CO;2-6},
  volume       = {32},
  year         = {2002},
}