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Bacterial-host interactions : Physiology and pathophysiology of respiratory infection

Hakansson, A. P. LU ; Orihuela, C. J. and Bogaert, D. (2018) In Physiological Reviews 98(2). p.781-811
Abstract

It has long been thought that respiratory infections are the direct result of acquisition of pathogenic viruses or bacteria, followed by their overgrowth, dissemination, and in some instances tissue invasion. In the last decades, it has become apparent that in contrast to this classical view, the majority of microorganisms associated with respiratory infections and inflammation are actually common members of the respiratory ecosystem and only in rare circumstances do they cause disease. This suggests that a complex interplay between host, environment, and properties of colonizing microorganisms together determines disease development and its severity. To understand the pathophysiological processes that underlie respiratory infectious... (More)

It has long been thought that respiratory infections are the direct result of acquisition of pathogenic viruses or bacteria, followed by their overgrowth, dissemination, and in some instances tissue invasion. In the last decades, it has become apparent that in contrast to this classical view, the majority of microorganisms associated with respiratory infections and inflammation are actually common members of the respiratory ecosystem and only in rare circumstances do they cause disease. This suggests that a complex interplay between host, environment, and properties of colonizing microorganisms together determines disease development and its severity. To understand the pathophysiological processes that underlie respiratory infectious diseases, it is therefore necessary to understand the host-bacterial interactions occurring at mucosal surfaces, along with the microbes inhabiting them, during symbiosis. Current knowledge regarding host-bacterial interactions during asymptomatic colonization will be discussed, including a plausible role for the human microbiome in maintaining a healthy state. With this as a starting point, we will discuss possible disruptive factors contributing to dysbiosis, which is likely to be a key trigger for pathobionts in the development and pathophysiology of respiratory diseases. Finally, from this renewed perspective, we will reflect on current and potential new approaches for treatment in the future.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Physiological Reviews
volume
98
issue
2
pages
31 pages
publisher
American Physiological Society
external identifiers
  • scopus:85043788881
ISSN
0031-9333
DOI
10.1152/physrev.00040.2016
language
English
LU publication?
yes
id
895a4ede-e105-4c42-9fdf-e53484f87368
date added to LUP
2018-03-28 13:15:46
date last changed
2019-08-14 04:13:12
@article{895a4ede-e105-4c42-9fdf-e53484f87368,
  abstract     = {<p>It has long been thought that respiratory infections are the direct result of acquisition of pathogenic viruses or bacteria, followed by their overgrowth, dissemination, and in some instances tissue invasion. In the last decades, it has become apparent that in contrast to this classical view, the majority of microorganisms associated with respiratory infections and inflammation are actually common members of the respiratory ecosystem and only in rare circumstances do they cause disease. This suggests that a complex interplay between host, environment, and properties of colonizing microorganisms together determines disease development and its severity. To understand the pathophysiological processes that underlie respiratory infectious diseases, it is therefore necessary to understand the host-bacterial interactions occurring at mucosal surfaces, along with the microbes inhabiting them, during symbiosis. Current knowledge regarding host-bacterial interactions during asymptomatic colonization will be discussed, including a plausible role for the human microbiome in maintaining a healthy state. With this as a starting point, we will discuss possible disruptive factors contributing to dysbiosis, which is likely to be a key trigger for pathobionts in the development and pathophysiology of respiratory diseases. Finally, from this renewed perspective, we will reflect on current and potential new approaches for treatment in the future.</p>},
  author       = {Hakansson, A. P. and Orihuela, C. J. and Bogaert, D.},
  issn         = {0031-9333},
  language     = {eng},
  number       = {2},
  pages        = {781--811},
  publisher    = {American Physiological Society},
  series       = {Physiological Reviews},
  title        = {Bacterial-host interactions : Physiology and pathophysiology of respiratory infection},
  url          = {http://dx.doi.org/10.1152/physrev.00040.2016},
  volume       = {98},
  year         = {2018},
}