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Vitamin D in normal and pathological parathyroid glands: New prospects for treating hyperparathyroidism (Review)

Buchwald, Pamela LU ; Westin, G and Akerstrom, G (2005) In International Journal of Molecular Medicine 15(4). p.701-706
Abstract
The secosteroid hormone active vitamin D [1,25(OH)(2)D-3] is a key player in the regulation of calcium homeostasis and bone mineralization. In addition, it has antiproliferative and prodifferentiating effects on various cells in vitro and in vivo. The action of 1,25(OH)(2)D-3 is mediated through the vitamin D receptor (VDR), which belongs to the superfamily of steroid/thyroid hormone nuclear receptors. VDR is expressed in the intestine, bone, kidney, parathyroid glands, and in many other tissues and cell types. In the parathyroid glands, 1,25(OH)(2)D-3 markedly decreases parathyroid hormone gene transcription and parathyroid cell proliferation and induces parathyroid cell differentiation. Diminished VDR expression is frequent in... (More)
The secosteroid hormone active vitamin D [1,25(OH)(2)D-3] is a key player in the regulation of calcium homeostasis and bone mineralization. In addition, it has antiproliferative and prodifferentiating effects on various cells in vitro and in vivo. The action of 1,25(OH)(2)D-3 is mediated through the vitamin D receptor (VDR), which belongs to the superfamily of steroid/thyroid hormone nuclear receptors. VDR is expressed in the intestine, bone, kidney, parathyroid glands, and in many other tissues and cell types. In the parathyroid glands, 1,25(OH)(2)D-3 markedly decreases parathyroid hormone gene transcription and parathyroid cell proliferation and induces parathyroid cell differentiation. Diminished VDR expression is frequent in parathyroid tumors and probably contributes to parathyroid tumorigenesis. The enzyme responsible for catalyzing synthesis of 1,25(OH)(2)D-3 (1 alpha-hydroxylase) has lately been demonstrated in the parathyroid glands. This indicates a new role for 1 alpha-hydroxylase as an intracrine modulator of vitamin D function in non-renal tissues, which recently has been recognized as crucial in parathyroid tumor development. The growth-inhibitory properties of 1,25(OH)(2)D-3 are prospects for treatment of hyperparathyroidism. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
uremia, hyperparathyroidism, 1 alpha-hydroxylase, vitamin D, parathyroid, adenoma
in
International Journal of Molecular Medicine
volume
15
issue
4
pages
701 - 706
publisher
D.A. Spandidos
external identifiers
  • wos:000227753700023
  • pmid:15754035
  • scopus:23044453030
ISSN
1791-244X
language
English
LU publication?
yes
id
8028bbff-602a-47a5-9d8b-dfb492e21c8c (old id 897081)
date added to LUP
2008-01-11 12:27:33
date last changed
2017-07-30 04:34:29
@article{8028bbff-602a-47a5-9d8b-dfb492e21c8c,
  abstract     = {The secosteroid hormone active vitamin D [1,25(OH)(2)D-3] is a key player in the regulation of calcium homeostasis and bone mineralization. In addition, it has antiproliferative and prodifferentiating effects on various cells in vitro and in vivo. The action of 1,25(OH)(2)D-3 is mediated through the vitamin D receptor (VDR), which belongs to the superfamily of steroid/thyroid hormone nuclear receptors. VDR is expressed in the intestine, bone, kidney, parathyroid glands, and in many other tissues and cell types. In the parathyroid glands, 1,25(OH)(2)D-3 markedly decreases parathyroid hormone gene transcription and parathyroid cell proliferation and induces parathyroid cell differentiation. Diminished VDR expression is frequent in parathyroid tumors and probably contributes to parathyroid tumorigenesis. The enzyme responsible for catalyzing synthesis of 1,25(OH)(2)D-3 (1 alpha-hydroxylase) has lately been demonstrated in the parathyroid glands. This indicates a new role for 1 alpha-hydroxylase as an intracrine modulator of vitamin D function in non-renal tissues, which recently has been recognized as crucial in parathyroid tumor development. The growth-inhibitory properties of 1,25(OH)(2)D-3 are prospects for treatment of hyperparathyroidism.},
  author       = {Buchwald, Pamela and Westin, G and Akerstrom, G},
  issn         = {1791-244X},
  keyword      = {uremia,hyperparathyroidism,1 alpha-hydroxylase,vitamin D,parathyroid,adenoma},
  language     = {eng},
  number       = {4},
  pages        = {701--706},
  publisher    = {D.A. Spandidos},
  series       = {International Journal of Molecular Medicine},
  title        = {Vitamin D in normal and pathological parathyroid glands: New prospects for treating hyperparathyroidism (Review)},
  volume       = {15},
  year         = {2005},
}