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Albuminuria and hypertension are independently associated with circulating antipericyte autoantibodies in type 2 diabetic patients

Nayak, RC; Agardh, Elisabet LU ; Kwok, MGK; Farthing-Nayak, PJ; Lynch, Kristian LU and Agardh, Carl-David LU (2005) In Metabolism, Clinical and Experimental 54(2). p.188-193
Abstract
Aims: To determine whether albuminuria, hypertension, or HbA(1c) are independently associated with antipericyte autoantibodies (APAAs) in type 2 diabetes mellitus. Methods: Two hundred ninety-nine subjects with different degrees of retinopathy according to the Early Treatment Diabetic Retinopathy Study Scale participated in this study. Albuminuria was defined as an albumin/creatinine ratio above the normal cutoff limit, that is, 2.0 g/mol for men and 2.8 g/mol for women. Hypertension was defined as a diastolic blood pressure more than 90 mm Hg, a systolic blood pressure more than 140 mm Hg, or pharmacological antihypertensive treatment. Serum APAAs were detected by immunofluorescence on tissue-cultured bovine retinal pericytes. Association... (More)
Aims: To determine whether albuminuria, hypertension, or HbA(1c) are independently associated with antipericyte autoantibodies (APAAs) in type 2 diabetes mellitus. Methods: Two hundred ninety-nine subjects with different degrees of retinopathy according to the Early Treatment Diabetic Retinopathy Study Scale participated in this study. Albuminuria was defined as an albumin/creatinine ratio above the normal cutoff limit, that is, 2.0 g/mol for men and 2.8 g/mol for women. Hypertension was defined as a diastolic blood pressure more than 90 mm Hg, a systolic blood pressure more than 140 mm Hg, or pharmacological antihypertensive treatment. Serum APAAs were detected by immunofluorescence on tissue-cultured bovine retinal pericytes. Association analysis was performed using univariate and multivariate statistical tools. Results: In type 2 diabetes, APAAs were independently associated with albuminuria (OR = 0.56; P < .04), hypertension (OR = 2.21; P < .01), as well as with proliferative retinopathy (OR = 0.39; P < .01). Conclusions: The increased prevalence of APAA in patients with hypertension may suggest that these antibodies are related to tissue damage and repair and that the decline in frequency with albuminuria may serve as a marker for more advanced angiopathy. Future longitudinal studies are needed to determine whether the frequency of APAA is associated with the progression of angiopathy, and to determine the biological activity and antigens recognized by the antibody. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Metabolism, Clinical and Experimental
volume
54
issue
2
pages
188 - 193
publisher
Elsevier
external identifiers
  • wos:000227141500008
  • pmid:15690312
  • scopus:12944325308
ISSN
1532-8600
DOI
10.1016/j.metabol.2004.08.011
language
English
LU publication?
yes
id
bf110b9a-5ca6-44ba-bed4-b699a5823bd2 (old id 897387)
date added to LUP
2008-01-16 15:27:40
date last changed
2017-01-01 07:16:03
@article{bf110b9a-5ca6-44ba-bed4-b699a5823bd2,
  abstract     = {Aims: To determine whether albuminuria, hypertension, or HbA(1c) are independently associated with antipericyte autoantibodies (APAAs) in type 2 diabetes mellitus. Methods: Two hundred ninety-nine subjects with different degrees of retinopathy according to the Early Treatment Diabetic Retinopathy Study Scale participated in this study. Albuminuria was defined as an albumin/creatinine ratio above the normal cutoff limit, that is, 2.0 g/mol for men and 2.8 g/mol for women. Hypertension was defined as a diastolic blood pressure more than 90 mm Hg, a systolic blood pressure more than 140 mm Hg, or pharmacological antihypertensive treatment. Serum APAAs were detected by immunofluorescence on tissue-cultured bovine retinal pericytes. Association analysis was performed using univariate and multivariate statistical tools. Results: In type 2 diabetes, APAAs were independently associated with albuminuria (OR = 0.56; P &lt; .04), hypertension (OR = 2.21; P &lt; .01), as well as with proliferative retinopathy (OR = 0.39; P &lt; .01). Conclusions: The increased prevalence of APAA in patients with hypertension may suggest that these antibodies are related to tissue damage and repair and that the decline in frequency with albuminuria may serve as a marker for more advanced angiopathy. Future longitudinal studies are needed to determine whether the frequency of APAA is associated with the progression of angiopathy, and to determine the biological activity and antigens recognized by the antibody.},
  author       = {Nayak, RC and Agardh, Elisabet and Kwok, MGK and Farthing-Nayak, PJ and Lynch, Kristian and Agardh, Carl-David},
  issn         = {1532-8600},
  language     = {eng},
  number       = {2},
  pages        = {188--193},
  publisher    = {Elsevier},
  series       = {Metabolism, Clinical and Experimental},
  title        = {Albuminuria and hypertension are independently associated with circulating antipericyte autoantibodies in type 2 diabetic patients},
  url          = {http://dx.doi.org/10.1016/j.metabol.2004.08.011},
  volume       = {54},
  year         = {2005},
}