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Chlamydial antibodies and risk of prostate cancer

Anttila, T; Tenkanen, L; Lumme, S; Leinonen, M; Gislefoss, RE; Hallmans, G; Thoresen, S; Hakulinen, T; Luostarinen, T and Stattin, P, et al. (2005) In Cancer Epidemiology Biomarkers & Prevention 14(2). p.385-389
Abstract
Objective: We assessed the risk of prostate cancer by exposure to Chlamydia trachomatis. Method: Seven hundred thirty eight cases of prostate cancer and 2,271 matched controls were identified from three serum sample banks in Finland, Norway, and Sweden by linkage to the population based cancer registries. Results: A statistically significant inverse association (odds ratio, 0.69; 95% confidence interval, 0.51-0.94) was found. It was consistent by different serotypes and there was a consistent dose-response relationship. Conclusion: C. trachomatis infection is not likely to increase the risk of prostate cancer. Whether the inverse relationship is true or due to difficulties in measuring the true exposure in prostatic tissue by serology,... (More)
Objective: We assessed the risk of prostate cancer by exposure to Chlamydia trachomatis. Method: Seven hundred thirty eight cases of prostate cancer and 2,271 matched controls were identified from three serum sample banks in Finland, Norway, and Sweden by linkage to the population based cancer registries. Results: A statistically significant inverse association (odds ratio, 0.69; 95% confidence interval, 0.51-0.94) was found. It was consistent by different serotypes and there was a consistent dose-response relationship. Conclusion: C. trachomatis infection is not likely to increase the risk of prostate cancer. Whether the inverse relationship is true or due to difficulties in measuring the true exposure in prostatic tissue by serology, confounders or other sources of error remain open. (Less)
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Contribution to journal
publication status
published
subject
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Cancer Epidemiology Biomarkers & Prevention
volume
14
issue
2
pages
385 - 389
publisher
American Association for Cancer Research
external identifiers
  • wos:000227113800015
  • pmid:15734962
  • scopus:20944450872
ISSN
1538-7755
language
English
LU publication?
yes
id
454208c6-0b2a-4875-8a20-84ec10a20018 (old id 897421)
alternative location
http://cebp.aacrjournals.org/cgi/content/full/14/2/385
date added to LUP
2008-01-11 10:58:16
date last changed
2017-01-01 07:16:42
@article{454208c6-0b2a-4875-8a20-84ec10a20018,
  abstract     = {Objective: We assessed the risk of prostate cancer by exposure to Chlamydia trachomatis. Method: Seven hundred thirty eight cases of prostate cancer and 2,271 matched controls were identified from three serum sample banks in Finland, Norway, and Sweden by linkage to the population based cancer registries. Results: A statistically significant inverse association (odds ratio, 0.69; 95% confidence interval, 0.51-0.94) was found. It was consistent by different serotypes and there was a consistent dose-response relationship. Conclusion: C. trachomatis infection is not likely to increase the risk of prostate cancer. Whether the inverse relationship is true or due to difficulties in measuring the true exposure in prostatic tissue by serology, confounders or other sources of error remain open.},
  author       = {Anttila, T and Tenkanen, L and Lumme, S and Leinonen, M and Gislefoss, RE and Hallmans, G and Thoresen, S and Hakulinen, T and Luostarinen, T and Stattin, P and Saikku, P and Dillner, J and Lehtinen, M and Anttila, T and Tenkanen, L and Lumme, S and Leinonen, M and Gislefoss, RE and Hallmans, G and Thoresen, S and Hakulinen, T and Luostarinen, T and Stattin, P and Saikku, P and Dillner, Joakim and Lehtinen, M and Hakama, M},
  issn         = {1538-7755},
  language     = {eng},
  number       = {2},
  pages        = {385--389},
  publisher    = {American Association for Cancer Research},
  series       = {Cancer Epidemiology Biomarkers & Prevention},
  title        = {Chlamydial antibodies and risk of prostate cancer},
  volume       = {14},
  year         = {2005},
}