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Asymptomatic atherosclerosis and myocardial infarction: Risk modified by ability to adapt to stressful situations. Results from prospective cohort study "Men born in 1914", Malmo, Sweden

André-Petersson, Lena LU ; Hedblad, Bo LU ; Janzon, Lars LU and Steen, G (2004) In Medical Science Monitor 10(10). p.549-556
Abstract
Background: The purpose of this study was to investigate whether different behaviors in a stressful situation modify the risk of atherosclerosis in association with a myocardial infarction, cardiovascular mortality, and all-cause mortality. Many individuals have atherosclerotic changes in their arteries but may never experience any symptoms nor develop cardiovascular disease. A myocardial infarction is caused by a disruption of a vulnerable atherosclerotic plaque. The mechanisms that trigger these events are not fully understood, but among the proposed agents is psychological stress. A differential in risk exposure could be expected since individuals differ in their ability to cope with stressful situations. Materials/Methods: In the... (More)
Background: The purpose of this study was to investigate whether different behaviors in a stressful situation modify the risk of atherosclerosis in association with a myocardial infarction, cardiovascular mortality, and all-cause mortality. Many individuals have atherosclerotic changes in their arteries but may never experience any symptoms nor develop cardiovascular disease. A myocardial infarction is caused by a disruption of a vulnerable atherosclerotic plaque. The mechanisms that trigger these events are not fully understood, but among the proposed agents is psychological stress. A differential in risk exposure could be expected since individuals differ in their ability to cope with stressful situations. Materials/Methods: In the prospective cohort study "Men born in 1914", atherosclerosis was noninvasively studied in the peripheral, carotid, and coronary arteries at a baseline examination in 1982/83. The serial Color Word Test, which is a semi-experimental way to assess how individuals adapt in a stressful situation, was administered at the same examination. Participants were followed-up regarding incidence of myocardial infarction and mortality until December 31 1996. Results: Atherosclerosis was associated with an increased risk of myocardial infarction (relative risk (RR) 2.96; 95% confidence interval (CI) 1.52 to 5.74) and cardiovascular mortality (RR 3.31; 95% Cl 2.08 to 5.28) during follow-up only among the men who showed maladaptive behavior. No excess risk could be established in men with an adaptive behavior pattern. Conclusions: The serial Color Word Test can assist in identifying men at high cardiovascular risk (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
atherosclerosis, adaptive behavior, stress, noninvasive detection, Color Word Test
in
Medical Science Monitor
volume
10
issue
10
pages
549 - 556
publisher
Medical Science Monitor
external identifiers
  • wos:000224834000007
  • pmid:15448593
  • scopus:7044227598
ISSN
1643-3750
language
English
LU publication?
yes
id
8f07f749-bc75-4336-8129-a155f0fe2bec (old id 897989)
alternative location
http://www.medscimonit.com/abstracted.php?level=5&icid=11781
date added to LUP
2008-01-10 10:57:14
date last changed
2017-01-01 05:14:28
@article{8f07f749-bc75-4336-8129-a155f0fe2bec,
  abstract     = {Background: The purpose of this study was to investigate whether different behaviors in a stressful situation modify the risk of atherosclerosis in association with a myocardial infarction, cardiovascular mortality, and all-cause mortality. Many individuals have atherosclerotic changes in their arteries but may never experience any symptoms nor develop cardiovascular disease. A myocardial infarction is caused by a disruption of a vulnerable atherosclerotic plaque. The mechanisms that trigger these events are not fully understood, but among the proposed agents is psychological stress. A differential in risk exposure could be expected since individuals differ in their ability to cope with stressful situations. Materials/Methods: In the prospective cohort study "Men born in 1914", atherosclerosis was noninvasively studied in the peripheral, carotid, and coronary arteries at a baseline examination in 1982/83. The serial Color Word Test, which is a semi-experimental way to assess how individuals adapt in a stressful situation, was administered at the same examination. Participants were followed-up regarding incidence of myocardial infarction and mortality until December 31 1996. Results: Atherosclerosis was associated with an increased risk of myocardial infarction (relative risk (RR) 2.96; 95% confidence interval (CI) 1.52 to 5.74) and cardiovascular mortality (RR 3.31; 95% Cl 2.08 to 5.28) during follow-up only among the men who showed maladaptive behavior. No excess risk could be established in men with an adaptive behavior pattern. Conclusions: The serial Color Word Test can assist in identifying men at high cardiovascular risk},
  author       = {André-Petersson, Lena and Hedblad, Bo and Janzon, Lars and Steen, G},
  issn         = {1643-3750},
  keyword      = {atherosclerosis,adaptive behavior,stress,noninvasive detection,Color Word Test},
  language     = {eng},
  number       = {10},
  pages        = {549--556},
  publisher    = {Medical Science Monitor},
  series       = {Medical Science Monitor},
  title        = {Asymptomatic atherosclerosis and myocardial infarction: Risk modified by ability to adapt to stressful situations. Results from prospective cohort study "Men born in 1914", Malmo, Sweden},
  volume       = {10},
  year         = {2004},
}