Advanced

Toward imaging biomarkers for osteoarthritis

Gray, ML; Eckstein, F; Peterfy, C; Dahlberg, Leif LU ; Kim, YJ and Sorensen, AG (2004) In Clinical Orthopaedics and Related Research p.175-181
Abstract
Many new therapeutic strategies have been and are being developed to correct, prevent, or slow the progression of osteoarthritis. Our ability to evaluate the efficacy of these techniques, or to determine the situations for which they might provide the most benefit, critically depends on diagnostic measures that can serve as proxies for the present or predicted state of the cartilage. Many of the magnetic resonance imaging techniques that have been emerging over the past decades appear promising in that they have shown technical validity in measuring the morphologic and molecular state of cartilage. With continued development and added insight from pilot clinical studies, these or related methods may soon be in customary use. These... (More)
Many new therapeutic strategies have been and are being developed to correct, prevent, or slow the progression of osteoarthritis. Our ability to evaluate the efficacy of these techniques, or to determine the situations for which they might provide the most benefit, critically depends on diagnostic measures that can serve as proxies for the present or predicted state of the cartilage. Many of the magnetic resonance imaging techniques that have been emerging over the past decades appear promising in that they have shown technical validity in measuring the morphologic and molecular state of cartilage. With continued development and added insight from pilot clinical studies, these or related methods may soon be in customary use. These techniques are part of a paradigm shift where therapeutic strategies are developed hand-in-hand with diagnostic approaches-a shift that offers the promise of speeding development of effective therapies, and focusing their use in areas where they can be most successful. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical Orthopaedics and Related Research
issue
427
pages
175 - 181
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000224524400029
  • scopus:5444252070
ISSN
0009-921X
DOI
10.1097/01.blo.0000144972.50849.d9
language
English
LU publication?
yes
id
34a858bb-b278-406c-aa41-dc1de6519b77 (old id 898061)
alternative location
http://www.corronline.com/pt/re/corr/abstract.00003086-200410001-00029.htm
date added to LUP
2008-01-10 15:47:46
date last changed
2017-10-01 03:44:35
@article{34a858bb-b278-406c-aa41-dc1de6519b77,
  abstract     = {Many new therapeutic strategies have been and are being developed to correct, prevent, or slow the progression of osteoarthritis. Our ability to evaluate the efficacy of these techniques, or to determine the situations for which they might provide the most benefit, critically depends on diagnostic measures that can serve as proxies for the present or predicted state of the cartilage. Many of the magnetic resonance imaging techniques that have been emerging over the past decades appear promising in that they have shown technical validity in measuring the morphologic and molecular state of cartilage. With continued development and added insight from pilot clinical studies, these or related methods may soon be in customary use. These techniques are part of a paradigm shift where therapeutic strategies are developed hand-in-hand with diagnostic approaches-a shift that offers the promise of speeding development of effective therapies, and focusing their use in areas where they can be most successful.},
  author       = {Gray, ML and Eckstein, F and Peterfy, C and Dahlberg, Leif and Kim, YJ and Sorensen, AG},
  issn         = {0009-921X},
  language     = {eng},
  number       = {427},
  pages        = {175--181},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Clinical Orthopaedics and Related Research},
  title        = {Toward imaging biomarkers for osteoarthritis},
  url          = {http://dx.doi.org/10.1097/01.blo.0000144972.50849.d9},
  year         = {2004},
}