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Genetic association of CDC2 with cerebrospinal fluid tau in Alzheimer's disease

Johansson, A; Zetterberg, H; Hampel, H; Buerger, K; Prince, JA; Minthon, Lennart LU ; Wahlund, LO and Blennow, K (2005) In Dementia and Geriatric Cognitive Disorders 20(6). p.367-374
Abstract
We have recently reported that a polymorphism in the cell division cycle (CDC2) gene, designated Ex6 + 7I/D, is associated with Alzheimer's disease (AD). The CDC2 gene is located on chromosome 10q21.1 close to the marker D10S1225 linked to AD. Active cdc2 accumulates in neurons containing neurofibrillary tangles (NFT), a process that can precede the formation of NFT. Therefore, CDC2 is a promising candidate susceptibility gene for AD. We investigated the possible effects of the CDC2 polymorphism on cerebrospinal fluid (CSF) biomarkers in AD patients. CDC2 genotypes were evaluated in relation to CSF protein levels of total tau, phospho-tau and beta-amyloid (1-42) in AD patients and control individuals, and in relation to the amount of... (More)
We have recently reported that a polymorphism in the cell division cycle (CDC2) gene, designated Ex6 + 7I/D, is associated with Alzheimer's disease (AD). The CDC2 gene is located on chromosome 10q21.1 close to the marker D10S1225 linked to AD. Active cdc2 accumulates in neurons containing neurofibrillary tangles (NFT), a process that can precede the formation of NFT. Therefore, CDC2 is a promising candidate susceptibility gene for AD. We investigated the possible effects of the CDC2 polymorphism on cerebrospinal fluid (CSF) biomarkers in AD patients. CDC2 genotypes were evaluated in relation to CSF protein levels of total tau, phospho-tau and beta-amyloid (1-42) in AD patients and control individuals, and in relation to the amount of senile plaques and NFT in the frontal cortex and in the hippocampus in patients with autopsy-proven AD and controls. The CDC2 Ex6 + 7I allele was associated with a gene dose-dependent increase of CSF total tau levels (F-2,F- 626 = 7.0, p = 0.001) and the homozygous CDC2Ex6 +7II genotype was significantly more frequent among AD patients compared to controls (p = 0.006, OR = 1.57, 95% CI 1.13-2.17). Our results provide further evidence for an involvement of cdc2 in the pathogenesis of AD. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alzheimer's disease, CDC2, cell cycle, tau, beta-amyloid
in
Dementia and Geriatric Cognitive Disorders
volume
20
issue
6
pages
367 - 374
publisher
Karger
external identifiers
  • pmid:16192727
  • wos:000233364300006
  • scopus:27844601188
ISSN
1420-8008
DOI
10.1159/000088634
language
English
LU publication?
yes
id
2905f06f-3680-43fd-9dd2-e239ffe5ae05 (old id 898726)
date added to LUP
2008-01-16 11:42:14
date last changed
2017-01-01 05:05:07
@article{2905f06f-3680-43fd-9dd2-e239ffe5ae05,
  abstract     = {We have recently reported that a polymorphism in the cell division cycle (CDC2) gene, designated Ex6 + 7I/D, is associated with Alzheimer's disease (AD). The CDC2 gene is located on chromosome 10q21.1 close to the marker D10S1225 linked to AD. Active cdc2 accumulates in neurons containing neurofibrillary tangles (NFT), a process that can precede the formation of NFT. Therefore, CDC2 is a promising candidate susceptibility gene for AD. We investigated the possible effects of the CDC2 polymorphism on cerebrospinal fluid (CSF) biomarkers in AD patients. CDC2 genotypes were evaluated in relation to CSF protein levels of total tau, phospho-tau and beta-amyloid (1-42) in AD patients and control individuals, and in relation to the amount of senile plaques and NFT in the frontal cortex and in the hippocampus in patients with autopsy-proven AD and controls. The CDC2 Ex6 + 7I allele was associated with a gene dose-dependent increase of CSF total tau levels (F-2,F- 626 = 7.0, p = 0.001) and the homozygous CDC2Ex6 +7II genotype was significantly more frequent among AD patients compared to controls (p = 0.006, OR = 1.57, 95% CI 1.13-2.17). Our results provide further evidence for an involvement of cdc2 in the pathogenesis of AD.},
  author       = {Johansson, A and Zetterberg, H and Hampel, H and Buerger, K and Prince, JA and Minthon, Lennart and Wahlund, LO and Blennow, K},
  issn         = {1420-8008},
  keyword      = {Alzheimer's disease,CDC2,cell cycle,tau,beta-amyloid},
  language     = {eng},
  number       = {6},
  pages        = {367--374},
  publisher    = {Karger},
  series       = {Dementia and Geriatric Cognitive Disorders},
  title        = {Genetic association of CDC2 with cerebrospinal fluid tau in Alzheimer's disease},
  url          = {http://dx.doi.org/10.1159/000088634},
  volume       = {20},
  year         = {2005},
}