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Detecting the vulnerable carotid plaque : The Carotid Artery Multimodality imaging Prognostic study design

Gargani, Luna ; Baldini, Matteo ; Berchiolli, Raffaella ; Bort, Ida Rebecca ; Casolo, Giancarlo ; Chiappino, Dante ; Cosottini, Mirco ; D'Angelo, Gennaro ; De Santis, Mariella and Erba, Paola , et al. (2022) In Journal of Cardiovascular Medicine 23(7). p.466-473
Abstract

BackgroundCarotid artery disease is highly prevalent and a main cause of ischemic stroke and vascular dementia. There is a paucity of information on predictors of serious vascular events. Besides percentage diameter stenosis, international guidelines also recommend the evaluation of qualitative characteristics of carotid artery disease as a guide to treatment, but with no agreement on which qualitative features to assess. This inadequate knowledge leads to a poor ability to identify patients at risk, dispersion of medical resources, and unproven use of expensive and resource-consuming techniques, such as magnetic resonance imaging, positron emission tomography, and computed tomography.ObjectivesThe Carotid Artery Multimodality imaging... (More)

BackgroundCarotid artery disease is highly prevalent and a main cause of ischemic stroke and vascular dementia. There is a paucity of information on predictors of serious vascular events. Besides percentage diameter stenosis, international guidelines also recommend the evaluation of qualitative characteristics of carotid artery disease as a guide to treatment, but with no agreement on which qualitative features to assess. This inadequate knowledge leads to a poor ability to identify patients at risk, dispersion of medical resources, and unproven use of expensive and resource-consuming techniques, such as magnetic resonance imaging, positron emission tomography, and computed tomography.ObjectivesThe Carotid Artery Multimodality imaging Prognostic (CAMP) study will: prospectively determine the best predictors of silent and overt ischemic stroke and vascular dementia in patients with asymptomatic subcritical carotid artery disease by identifying the noninvasive diagnostic features of the 'vulnerable carotid plaque'; assess whether 'smart' use of low-cost diagnostic methods such as ultrasound-based evaluations may yield at least the same level of prospective information as more expensive techniques.Study designWe will compare the prognostic/predictive value of all proposed techniques with regard to silent or clinically manifest ischemic stroke and vascular dementia. The study will include ≥300 patients with asymptomatic, unilateral, intermediate degree (40-60% diameter) common or internal carotid artery stenosis detected at carotid ultrasound, with a 2-year follow-up. The study design has been registered on Clinicaltrial.gov on December 17, 2020 (ID number NCT04679727).

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
atherosclerosis, carotid artery disease, carotid artery plaque, carotid ultrasound, magnetic resonance imaging, stroke, vascular dementia, vascular imaging
in
Journal of Cardiovascular Medicine
volume
23
issue
7
pages
8 pages
publisher
Lippincott Williams & Wilkins
external identifiers
  • scopus:85133105905
  • pmid:35763768
ISSN
1558-2027
DOI
10.2459/JCM.0000000000001314
language
English
LU publication?
yes
id
898f7f36-b640-458f-a3a8-5489ea4d5ce3
date added to LUP
2022-10-10 13:35:52
date last changed
2024-06-13 12:42:31
@article{898f7f36-b640-458f-a3a8-5489ea4d5ce3,
  abstract     = {{<p>BackgroundCarotid artery disease is highly prevalent and a main cause of ischemic stroke and vascular dementia. There is a paucity of information on predictors of serious vascular events. Besides percentage diameter stenosis, international guidelines also recommend the evaluation of qualitative characteristics of carotid artery disease as a guide to treatment, but with no agreement on which qualitative features to assess. This inadequate knowledge leads to a poor ability to identify patients at risk, dispersion of medical resources, and unproven use of expensive and resource-consuming techniques, such as magnetic resonance imaging, positron emission tomography, and computed tomography.ObjectivesThe Carotid Artery Multimodality imaging Prognostic (CAMP) study will: prospectively determine the best predictors of silent and overt ischemic stroke and vascular dementia in patients with asymptomatic subcritical carotid artery disease by identifying the noninvasive diagnostic features of the 'vulnerable carotid plaque'; assess whether 'smart' use of low-cost diagnostic methods such as ultrasound-based evaluations may yield at least the same level of prospective information as more expensive techniques.Study designWe will compare the prognostic/predictive value of all proposed techniques with regard to silent or clinically manifest ischemic stroke and vascular dementia. The study will include ≥300 patients with asymptomatic, unilateral, intermediate degree (40-60% diameter) common or internal carotid artery stenosis detected at carotid ultrasound, with a 2-year follow-up. The study design has been registered on Clinicaltrial.gov on December 17, 2020 (ID number NCT04679727).</p>}},
  author       = {{Gargani, Luna and Baldini, Matteo and Berchiolli, Raffaella and Bort, Ida Rebecca and Casolo, Giancarlo and Chiappino, Dante and Cosottini, Mirco and D'Angelo, Gennaro and De Santis, Mariella and Erba, Paola and Fabiani, Iacopo and Fabiani, Plinio and Gabbriellini, Ilaria and Galeotti, Gian Giacomo and Ghicopulos, Irene and Goncalves, Isabel and Lapi, Simone and Masini, Gabriele and Morizzo, Carmela and Napoli, Vinicio and Nilsson, Jan and Orlandi, Giovanni and Palombo, Carlo and Pieraccini, Francesco and Ricci, Stefano and Siciliano, Gabriele and Slart, Riemer H.J.A. and De Caterina, Raffaele}},
  issn         = {{1558-2027}},
  keywords     = {{atherosclerosis; carotid artery disease; carotid artery plaque; carotid ultrasound; magnetic resonance imaging; stroke; vascular dementia; vascular imaging}},
  language     = {{eng}},
  month        = {{07}},
  number       = {{7}},
  pages        = {{466--473}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{Journal of Cardiovascular Medicine}},
  title        = {{Detecting the vulnerable carotid plaque : The Carotid Artery Multimodality imaging Prognostic study design}},
  url          = {{http://dx.doi.org/10.2459/JCM.0000000000001314}},
  doi          = {{10.2459/JCM.0000000000001314}},
  volume       = {{23}},
  year         = {{2022}},
}