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Photoallergic contact dermatitis from ketoprofen induced by drug-contaminated personal objects

Hindsén, Monica LU ; Isaksson, Marléne LU ; Persson, L; Zimersson, E and Bruze, Magnus LU (2004) In Journal of American Academy of Dermatology 50(2). p.215-219
Abstract
Background: Photoallergic contact dermatitis from ketoprofen has been recognized since the mid-1980s. Skin reactions have been reported to continue weeks after discontinuation of ketoprofen. One reason for this could be residual ketoprofen in the skin, which has been shown in a skin biopsy specimen. Objective: We sought to report on 3 cases of photoallergic contact dermatitis from ketoprofen in topical anti-inflammatory gels and on relapses of dermatitis appearing after use of ketoprofen-contaminated objects. Methods: We patch and photopatch tested, with standard series, the anti-inflammatory gel, ketoprofen, and its ingredients in serial dilutions and extracts of personal objects. We performed chemical investigations of personal objects... (More)
Background: Photoallergic contact dermatitis from ketoprofen has been recognized since the mid-1980s. Skin reactions have been reported to continue weeks after discontinuation of ketoprofen. One reason for this could be residual ketoprofen in the skin, which has been shown in a skin biopsy specimen. Objective: We sought to report on 3 cases of photoallergic contact dermatitis from ketoprofen in topical anti-inflammatory gels and on relapses of dermatitis appearing after use of ketoprofen-contaminated objects. Methods: We patch and photopatch tested, with standard series, the anti-inflammatory gel, ketoprofen, and its ingredients in serial dilutions and extracts of personal objects. We performed chemical investigations of personal objects with thin-layer chromatography, high-pressure liquid chromatography, and gas chromatography-mass spectrometry. Results: Photoallergy was demonstrated to ketoprofen, which was detected in personal objects. Conclusion: Relapses of photoallergic contact dermatitis in patients photoallergic to ketoprofen can be induced by ketoprofen-contaminated objects such as bandages and slippers. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of American Academy of Dermatology
volume
50
issue
2
pages
215 - 219
publisher
Elsevier
external identifiers
  • wos:000188710100007
  • scopus:0842310851
ISSN
0190-9622
DOI
10.1016/j.jaad.2003.07.007
language
English
LU publication?
yes
id
c0b2c840-1960-452c-9111-1869f88857b5 (old id 899404)
date added to LUP
2008-01-10 17:38:38
date last changed
2017-01-01 04:54:50
@article{c0b2c840-1960-452c-9111-1869f88857b5,
  abstract     = {Background: Photoallergic contact dermatitis from ketoprofen has been recognized since the mid-1980s. Skin reactions have been reported to continue weeks after discontinuation of ketoprofen. One reason for this could be residual ketoprofen in the skin, which has been shown in a skin biopsy specimen. Objective: We sought to report on 3 cases of photoallergic contact dermatitis from ketoprofen in topical anti-inflammatory gels and on relapses of dermatitis appearing after use of ketoprofen-contaminated objects. Methods: We patch and photopatch tested, with standard series, the anti-inflammatory gel, ketoprofen, and its ingredients in serial dilutions and extracts of personal objects. We performed chemical investigations of personal objects with thin-layer chromatography, high-pressure liquid chromatography, and gas chromatography-mass spectrometry. Results: Photoallergy was demonstrated to ketoprofen, which was detected in personal objects. Conclusion: Relapses of photoallergic contact dermatitis in patients photoallergic to ketoprofen can be induced by ketoprofen-contaminated objects such as bandages and slippers.},
  author       = {Hindsén, Monica and Isaksson, Marléne and Persson, L and Zimersson, E and Bruze, Magnus},
  issn         = {0190-9622},
  language     = {eng},
  number       = {2},
  pages        = {215--219},
  publisher    = {Elsevier},
  series       = {Journal of American Academy of Dermatology},
  title        = {Photoallergic contact dermatitis from ketoprofen induced by drug-contaminated personal objects},
  url          = {http://dx.doi.org/10.1016/j.jaad.2003.07.007},
  volume       = {50},
  year         = {2004},
}