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Exercise training meta-analysis of trials in patients with chronic heart failure (ExTraMATCH)

Piepoli, MF; Davos, C; Francis, DP; Coats, AJS; Belardinelli, R; Purcaro, A; Dubach, P; Myers, J; Giannuzzi, P and Temporelli, PL, et al. (2004) In B M J: British Medical Journal1995-01-01+01:00 328(7433). p.189-192
Abstract
Objective To determine the effect of exercise training on survival in patients with heart failure due to left ventricular systolic dysfunction. Design Collaborative meta-analysis. Inclusion criteria Randomised parallel group controlled trials of exercise training, for at least eight weeks with individual patient data on survival for at least three months. Studies reviewed Nine datasets, totalling 801 patients: 395 received exercise training and 406 were controls. Main outcome measure Death from all causes. Results During a mean (SD) follow up of 705 (729) days there were 88 (22%) deaths in the exercise arm and 105 (26%) in the control arm. Exercise training significantly reduced mortality (hazard ratio 0.65, 95% confidence interval, 0.46... (More)
Objective To determine the effect of exercise training on survival in patients with heart failure due to left ventricular systolic dysfunction. Design Collaborative meta-analysis. Inclusion criteria Randomised parallel group controlled trials of exercise training, for at least eight weeks with individual patient data on survival for at least three months. Studies reviewed Nine datasets, totalling 801 patients: 395 received exercise training and 406 were controls. Main outcome measure Death from all causes. Results During a mean (SD) follow up of 705 (729) days there were 88 (22%) deaths in the exercise arm and 105 (26%) in the control arm. Exercise training significantly reduced mortality (hazard ratio 0.65, 95% confidence interval, 0.46 to 0.92; log rank chi(2) = 5.9; P = 0.015). The secondary end point of death or admission to hospital was also reduced (0.72, 0.56 to 0.93; log rank chi(2) = 6.4; P = 0.011). No statistically significant subgroup specific treatment effect was observed. Conclusion Meta-analysis of randomised trials to date gives no evidence that properly supervised medical training programmes for patients with heart failure might be dangerous, and indeed there is clear evidence of an overall reduction in mortality. Further research should focus on optimising exercise programmes and identifying appropriate patient groups to target. (Less)
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B M J: British Medical Journal1995-01-01+01:00
volume
328
issue
7433
pages
189 - 192
publisher
BMJ Publishing Group
external identifiers
  • pmid:14729656
  • wos:000188652200011
  • scopus:0742287196
ISSN
1756-1833
DOI
10.1136/bmj.37938.645220.EE
language
English
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yes
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2b81bd8c-0744-491d-b7ab-f687b10117c0 (old id 899452)
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2008-01-18 11:07:54
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2017-11-05 03:35:42
@article{2b81bd8c-0744-491d-b7ab-f687b10117c0,
  abstract     = {Objective To determine the effect of exercise training on survival in patients with heart failure due to left ventricular systolic dysfunction. Design Collaborative meta-analysis. Inclusion criteria Randomised parallel group controlled trials of exercise training, for at least eight weeks with individual patient data on survival for at least three months. Studies reviewed Nine datasets, totalling 801 patients: 395 received exercise training and 406 were controls. Main outcome measure Death from all causes. Results During a mean (SD) follow up of 705 (729) days there were 88 (22%) deaths in the exercise arm and 105 (26%) in the control arm. Exercise training significantly reduced mortality (hazard ratio 0.65, 95% confidence interval, 0.46 to 0.92; log rank chi(2) = 5.9; P = 0.015). The secondary end point of death or admission to hospital was also reduced (0.72, 0.56 to 0.93; log rank chi(2) = 6.4; P = 0.011). No statistically significant subgroup specific treatment effect was observed. Conclusion Meta-analysis of randomised trials to date gives no evidence that properly supervised medical training programmes for patients with heart failure might be dangerous, and indeed there is clear evidence of an overall reduction in mortality. Further research should focus on optimising exercise programmes and identifying appropriate patient groups to target.},
  author       = {Piepoli, MF and Davos, C and Francis, DP and Coats, AJS and Belardinelli, R and Purcaro, A and Dubach, P and Myers, J and Giannuzzi, P and Temporelli, PL and Hambrecht, R and Linke, A and Kiilavuori, K and Leinonen, H and McKelvie, RS and Teo, KK and Volterrani, M and Giordano, A and Wielenga, RP and Baselier, MRP and Willenheimer, Ronnie and Rydberg, Erik and Adamopoulos, S and Dickestein, K and Gordon, A and Kostis, JB and Sellier, P and Toman, J},
  issn         = {1756-1833},
  language     = {eng},
  number       = {7433},
  pages        = {189--192},
  publisher    = {BMJ Publishing Group},
  series       = {B M J: British Medical Journal1995-01-01+01:00},
  title        = {Exercise training meta-analysis of trials in patients with chronic heart failure (ExTraMATCH)},
  url          = {http://dx.doi.org/10.1136/bmj.37938.645220.EE},
  volume       = {328},
  year         = {2004},
}