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The risk and burden of vertebral fractures in Sweden

Kanis, JA; Johnell, Olof LU ; Oden, A; Borgstrom, F; Zethraeus, N; De Laet, C and Jonsson, B (2004) In Osteoporosis International 15(1). p.20-26
Abstract
The aim of this study was to determine the risk and burden of vertebral fractures judged as those coming to clinical attention and as morphometric fractures. Incidence and utility loss were computed from data from Malmo, Sweden. Clinical fractures accounted for 23% of all vertebral deformities in women and for 42% in men. The average 10-year fracture probability for morphometric fractures increased with age in men from 2.9% at the age of 50 years (7.2% in women) to 8.4 at the age of 85 years (26.7% in women). As expected, probabilities increased with decreasing T-score for hip BMD. Cumulative utility loss from a clinical vertebral fracture was substantial and was 50-62% of that due to a hip fracture depending on age. When incidence of... (More)
The aim of this study was to determine the risk and burden of vertebral fractures judged as those coming to clinical attention and as morphometric fractures. Incidence and utility loss were computed from data from Malmo, Sweden. Clinical fractures accounted for 23% of all vertebral deformities in women and for 42% in men. The average 10-year fracture probability for morphometric fractures increased with age in men from 2.9% at the age of 50 years (7.2% in women) to 8.4 at the age of 85 years (26.7% in women). As expected, probabilities increased with decreasing T-score for hip BMD. Cumulative utility loss from a clinical vertebral fracture was substantial and was 50-62% of that due to a hip fracture depending on age. When incidence of fractures in the population was weighted by disutility, all spine fractures accounted for more morbidity than hip fracture up to the age of 75 years. We conclude that vertebral fractures have a major personal and societal impact that needs to be recognised in algorithms for assessment of risk and in health economic strategies for osteoporosis. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
vertebral fracture, utility, burden of fracture, osteoporotic fracture
in
Osteoporosis International
volume
15
issue
1
pages
20 - 26
publisher
Springer
external identifiers
  • wos:000188079200004
  • pmid:14593450
  • scopus:1342310684
ISSN
1433-2965
DOI
10.1007/s00198-003-1463-7
language
English
LU publication?
yes
id
c754cd71-de55-440c-bb5a-09cd6001a435 (old id 899502)
date added to LUP
2008-01-15 12:40:17
date last changed
2017-11-05 04:25:47
@article{c754cd71-de55-440c-bb5a-09cd6001a435,
  abstract     = {The aim of this study was to determine the risk and burden of vertebral fractures judged as those coming to clinical attention and as morphometric fractures. Incidence and utility loss were computed from data from Malmo, Sweden. Clinical fractures accounted for 23% of all vertebral deformities in women and for 42% in men. The average 10-year fracture probability for morphometric fractures increased with age in men from 2.9% at the age of 50 years (7.2% in women) to 8.4 at the age of 85 years (26.7% in women). As expected, probabilities increased with decreasing T-score for hip BMD. Cumulative utility loss from a clinical vertebral fracture was substantial and was 50-62% of that due to a hip fracture depending on age. When incidence of fractures in the population was weighted by disutility, all spine fractures accounted for more morbidity than hip fracture up to the age of 75 years. We conclude that vertebral fractures have a major personal and societal impact that needs to be recognised in algorithms for assessment of risk and in health economic strategies for osteoporosis.},
  author       = {Kanis, JA and Johnell, Olof and Oden, A and Borgstrom, F and Zethraeus, N and De Laet, C and Jonsson, B},
  issn         = {1433-2965},
  keyword      = {vertebral fracture,utility,burden of fracture,osteoporotic fracture},
  language     = {eng},
  number       = {1},
  pages        = {20--26},
  publisher    = {Springer},
  series       = {Osteoporosis International},
  title        = {The risk and burden of vertebral fractures in Sweden},
  url          = {http://dx.doi.org/10.1007/s00198-003-1463-7},
  volume       = {15},
  year         = {2004},
}