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Molecular imaging with endogenous substances

Golman, Klaes LU ; Ardenaer-Larsen, JH; Petersson, JS; Månsson, Sven LU and Leunbach, I (2003) In Proceedings of the National Academy of Sciences 100(18). p.10435-10439
Abstract
Dynamic nuclear polarization has enabled hyperpolarization of nuclei such as C-13 and N-15 in endogenous substances. The resulting high nuclear polarization makes it possible to perform subsecond C-13 MRI. By using the dynamic nuclear polarization hyperpolarization technique, 10% polarization was obtained in an aqueous solution of 100 mM C-13-labeled urea, ready for injection. The in vivo T, relaxation time of C-13 in the urea solution was determined to 20 +/- 2 s. Due to the long relaxation time, it is possible to use the hyperpolarized substance for medical imaging. A series of high-resolution (approximate to1-mm) magnetic resonance images were acquired, each with a scan time of 240 ms, 0-5 s after an i.v. injection of the hyperpolarized... (More)
Dynamic nuclear polarization has enabled hyperpolarization of nuclei such as C-13 and N-15 in endogenous substances. The resulting high nuclear polarization makes it possible to perform subsecond C-13 MRI. By using the dynamic nuclear polarization hyperpolarization technique, 10% polarization was obtained in an aqueous solution of 100 mM C-13-labeled urea, ready for injection. The in vivo T, relaxation time of C-13 in the urea solution was determined to 20 +/- 2 s. Due to the long relaxation time, it is possible to use the hyperpolarized substance for medical imaging. A series of high-resolution (approximate to1-mm) magnetic resonance images were acquired, each with a scan time of 240 ms, 0-5 s after an i.v. injection of the hyperpolarized aqueous [C-13]urea solution in a rat. The results show that it is possible to perform C-13 angiography with a signal-to-noise ratio of approximate to275 in approximate to0.25 s. Perfusion studies with endogenous substances may allow higher spatial and/or temporal resolution than is possible with current proton imaging techniques. (Less)
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type
Contribution to journal
publication status
published
subject
in
Proceedings of the National Academy of Sciences
volume
100
issue
18
pages
10435 - 10439
publisher
National Acad Sciences
external identifiers
  • wos:000185119300055
  • scopus:0041836259
ISSN
1091-6490
DOI
10.1073/pnas.1733836100
language
English
LU publication?
yes
id
7739d0e5-8ea0-4c74-ae22-886fc8fc0ee9 (old id 899989)
date added to LUP
2008-01-11 14:51:41
date last changed
2018-10-21 03:36:54
@article{7739d0e5-8ea0-4c74-ae22-886fc8fc0ee9,
  abstract     = {Dynamic nuclear polarization has enabled hyperpolarization of nuclei such as C-13 and N-15 in endogenous substances. The resulting high nuclear polarization makes it possible to perform subsecond C-13 MRI. By using the dynamic nuclear polarization hyperpolarization technique, 10% polarization was obtained in an aqueous solution of 100 mM C-13-labeled urea, ready for injection. The in vivo T, relaxation time of C-13 in the urea solution was determined to 20 +/- 2 s. Due to the long relaxation time, it is possible to use the hyperpolarized substance for medical imaging. A series of high-resolution (approximate to1-mm) magnetic resonance images were acquired, each with a scan time of 240 ms, 0-5 s after an i.v. injection of the hyperpolarized aqueous [C-13]urea solution in a rat. The results show that it is possible to perform C-13 angiography with a signal-to-noise ratio of approximate to275 in approximate to0.25 s. Perfusion studies with endogenous substances may allow higher spatial and/or temporal resolution than is possible with current proton imaging techniques.},
  author       = {Golman, Klaes and Ardenaer-Larsen, JH and Petersson, JS and Månsson, Sven and Leunbach, I},
  issn         = {1091-6490},
  language     = {eng},
  number       = {18},
  pages        = {10435--10439},
  publisher    = {National Acad Sciences},
  series       = {Proceedings of the National Academy of Sciences},
  title        = {Molecular imaging with endogenous substances},
  url          = {http://dx.doi.org/10.1073/pnas.1733836100},
  volume       = {100},
  year         = {2003},
}