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No relation between biomarkers at age 47-49 and aortic diameter after 14-19 years of follow-up - a population-based study

Taimour, Soumia LU ; Zarrouk, Moncef LU ; Holst, Jan LU ; Melander, Olle LU ; Engström, Gunnar LU ; Smith, J. Gustav LU and Gottsäter, Anders LU (2017) In Vasa - European Journal of Vascular Medicine 46(4). p.291-295
Abstract

BACKGROUND: Biomarkers reflecting diverse pathophysiological pathways may play an important role in the pathogenesis of abdominal aortic aneurysm (aortic diameter ≥30 mm, AAA), levels of many biomarkers are elevated and correlated to aortic diameter among 65-year-old men undergoing ultrasound (US) screening for AAA.

PROBANDS AND METHODS: To evaluate potential relationships between biomarkers and aortic dilatation after long-term follow-up, levels of C-reactive protein (CRP), proneurotensin (PNT), copeptin (CPT), lipoprotein-associated phospholipase 2 (Lp-PLA2), cystatin C (Cyst C), midregional proatrial natriuretic peptide (MR-proANP), and midregional proadrenomedullin (MR-proADM) were measured in 117 subjects (114 [97 %] men)... (More)

BACKGROUND: Biomarkers reflecting diverse pathophysiological pathways may play an important role in the pathogenesis of abdominal aortic aneurysm (aortic diameter ≥30 mm, AAA), levels of many biomarkers are elevated and correlated to aortic diameter among 65-year-old men undergoing ultrasound (US) screening for AAA.

PROBANDS AND METHODS: To evaluate potential relationships between biomarkers and aortic dilatation after long-term follow-up, levels of C-reactive protein (CRP), proneurotensin (PNT), copeptin (CPT), lipoprotein-associated phospholipase 2 (Lp-PLA2), cystatin C (Cyst C), midregional proatrial natriuretic peptide (MR-proANP), and midregional proadrenomedullin (MR-proADM) were measured in 117 subjects (114 [97 %] men) aged 47-49 in a prospective population-based cohort study, and related to aortic diameter at US examination of the aorta after 14-19 years of follow-up.

RESULTS: Biomarker levels at baseline did not correlate with aortic diameter after 14-19 years of follow up (CRP [r = 0.153], PNT [r = 0.070], CPT [r = -.156], Lp-PLA2 [r = .024], Cyst C [r = -.015], MR-proANP [r = 0.014], MR-proADM [r = -.117]). Adjusting for age and smoking at baseline in a linear regression model did not reveal any significant correlations.

CONCLUSIONS: Tested biomarker levels at age 47-49 were not associated with aortic diameter at ultrasound examination after 14-19 years of follow-up. If there are relationships between these biomarkers and aortic dilatation, they are not relevant until closer to AAA diagnosis.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Biomarkers, Aortic diameter, Aortic Aneurysm
in
Vasa - European Journal of Vascular Medicine
volume
46
issue
4
pages
5 pages
publisher
Hans Huber
external identifiers
  • scopus:85024492655
  • wos:000408059800009
ISSN
0301-1526
DOI
10.1024/0301-1526/a000632
language
English
LU publication?
yes
id
89b3ddb7-71f7-4d56-b910-c44767f5c7c6
date added to LUP
2017-05-29 11:28:36
date last changed
2018-03-18 05:13:03
@article{89b3ddb7-71f7-4d56-b910-c44767f5c7c6,
  abstract     = {<p>BACKGROUND: Biomarkers reflecting diverse pathophysiological pathways may play an important role in the pathogenesis of abdominal aortic aneurysm (aortic diameter ≥30 mm, AAA), levels of many biomarkers are elevated and correlated to aortic diameter among 65-year-old men undergoing ultrasound (US) screening for AAA.</p><p>PROBANDS AND METHODS: To evaluate potential relationships between biomarkers and aortic dilatation after long-term follow-up, levels of C-reactive protein (CRP), proneurotensin (PNT), copeptin (CPT), lipoprotein-associated phospholipase 2 (Lp-PLA2), cystatin C (Cyst C), midregional proatrial natriuretic peptide (MR-proANP), and midregional proadrenomedullin (MR-proADM) were measured in 117 subjects (114 [97 %] men) aged 47-49 in a prospective population-based cohort study, and related to aortic diameter at US examination of the aorta after 14-19 years of follow-up.</p><p>RESULTS: Biomarker levels at baseline did not correlate with aortic diameter after 14-19 years of follow up (CRP [r = 0.153], PNT [r = 0.070], CPT [r = -.156], Lp-PLA2 [r = .024], Cyst C [r = -.015], MR-proANP [r = 0.014], MR-proADM [r = -.117]). Adjusting for age and smoking at baseline in a linear regression model did not reveal any significant correlations.</p><p>CONCLUSIONS: Tested biomarker levels at age 47-49 were not associated with aortic diameter at ultrasound examination after 14-19 years of follow-up. If there are relationships between these biomarkers and aortic dilatation, they are not relevant until closer to AAA diagnosis.</p>},
  author       = {Taimour, Soumia and Zarrouk, Moncef and Holst, Jan and Melander, Olle and Engström, Gunnar and Smith, J. Gustav and Gottsäter, Anders},
  issn         = {0301-1526},
  keyword      = {Biomarkers,Aortic diameter,Aortic Aneurysm},
  language     = {eng},
  month        = {04},
  number       = {4},
  pages        = {291--295},
  publisher    = {Hans Huber},
  series       = {Vasa - European Journal of Vascular Medicine},
  title        = {No relation between biomarkers at age 47-49 and aortic diameter after 14-19 years of follow-up - a population-based study},
  url          = {http://dx.doi.org/10.1024/0301-1526/a000632},
  volume       = {46},
  year         = {2017},
}