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Impact of cardiopulmonary bypass and surgical complexity on plasma soluble urokinase-type plasminogen activator receptor levels after cardiac surgery

Dardashti, Alain LU ; Sterner, Niklas ; Fisher, Jane LU ; Thelaus, Louise LU ; Nilsson, Johan LU orcid ; Linder, Adam LU and Zindovic, Igor LU (2021) In Scandinavian Journal of Clinical and Laboratory Investigation 81(8). p.634-640
Abstract

Background: Circulating soluble urokinase plasminogen activator receptor (suPAR) is a marker of inflammation with prognostic value for elevated risk of morbidity and mortality. It has not yet been shown how the inflammatory process induced by cardiac surgery affects suPAR concentrations postoperatively Methods: In a prospective observational study, plasma suPAR levels were measured in 30 patients undergoing cardiac surgery with cardiopulmonary bypass (CPB), pre-, peri, post-operatively, and 3–5 days after surgery. Fifteen patients underwent coronary artery bypass grafting (CABG) and 15 underwent complex procedures with longer CPB duration. Concentrations of suPAR at each time point were compared to the preoperative levels and compared... (More)

Background: Circulating soluble urokinase plasminogen activator receptor (suPAR) is a marker of inflammation with prognostic value for elevated risk of morbidity and mortality. It has not yet been shown how the inflammatory process induced by cardiac surgery affects suPAR concentrations postoperatively Methods: In a prospective observational study, plasma suPAR levels were measured in 30 patients undergoing cardiac surgery with cardiopulmonary bypass (CPB), pre-, peri, post-operatively, and 3–5 days after surgery. Fifteen patients underwent coronary artery bypass grafting (CABG) and 15 underwent complex procedures with longer CPB duration. Concentrations of suPAR at each time point were compared to the preoperative levels and compared between the two groups. Results: In both groups, plasma suPAR concentrations were significantly higher on the first postoperative day (3.27 (interquartile range (IQR) 2.75–3.86) µg/L compared to baseline (2.62 (1.98–3.86)) µg/L, p <.001. There were no significant differences in suPAR concentrations between the groups at any time point. Preoperatively, the median suPAR concentration was 2.57 (2.01–3.60) µg/L in the CABG group versus 2.67 (1.89–3.97) µg/L in the complex group (p =.567). At ICU arrival 2.48 (2.34–3.23) µg/L versus 2.73 (2.28–3.44) µg/L in CABG and complex patients, respectively (p =.914). There was no difference in suPAR concentrations between the groups on postoperative day 1 (3.34 (2.89–3.89) versus 3.19 (2.57–3.62) p =.967) or 3–5 days after surgery (2.72 (1.98–3.16) versus 2.96 (2.39–4.28) p =.085. Conclusions: After a transient rise on the first postoperative day, the suPAR levels returned to the preoperative levels by the third postoperative day. There was no significant difference in suPAR levels between the routine CABG and complex group with longer CPB time.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cardiac surgery, cardiopulmonary bypass, prognosis, receptors, urokinase plasminogen activator
in
Scandinavian Journal of Clinical and Laboratory Investigation
volume
81
issue
8
pages
634 - 640
publisher
Informa Healthcare
external identifiers
  • scopus:85118115992
  • pmid:34657538
ISSN
0036-5513
DOI
10.1080/00365513.2021.1990395
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2021 Medisinsk Fysiologisk Forenings Forlag (MFFF).
id
89bd1fa9-2080-400e-b4f1-981325cedb90
date added to LUP
2021-11-24 09:05:18
date last changed
2024-06-15 21:25:29
@article{89bd1fa9-2080-400e-b4f1-981325cedb90,
  abstract     = {{<p>Background: Circulating soluble urokinase plasminogen activator receptor (suPAR) is a marker of inflammation with prognostic value for elevated risk of morbidity and mortality. It has not yet been shown how the inflammatory process induced by cardiac surgery affects suPAR concentrations postoperatively Methods: In a prospective observational study, plasma suPAR levels were measured in 30 patients undergoing cardiac surgery with cardiopulmonary bypass (CPB), pre-, peri, post-operatively, and 3–5 days after surgery. Fifteen patients underwent coronary artery bypass grafting (CABG) and 15 underwent complex procedures with longer CPB duration. Concentrations of suPAR at each time point were compared to the preoperative levels and compared between the two groups. Results: In both groups, plasma suPAR concentrations were significantly higher on the first postoperative day (3.27 (interquartile range (IQR) 2.75–3.86) µg/L compared to baseline (2.62 (1.98–3.86)) µg/L, p &lt;.001. There were no significant differences in suPAR concentrations between the groups at any time point. Preoperatively, the median suPAR concentration was 2.57 (2.01–3.60) µg/L in the CABG group versus 2.67 (1.89–3.97) µg/L in the complex group (p =.567). At ICU arrival 2.48 (2.34–3.23) µg/L versus 2.73 (2.28–3.44) µg/L in CABG and complex patients, respectively (p =.914). There was no difference in suPAR concentrations between the groups on postoperative day 1 (3.34 (2.89–3.89) versus 3.19 (2.57–3.62) p =.967) or 3–5 days after surgery (2.72 (1.98–3.16) versus 2.96 (2.39–4.28) p =.085. Conclusions: After a transient rise on the first postoperative day, the suPAR levels returned to the preoperative levels by the third postoperative day. There was no significant difference in suPAR levels between the routine CABG and complex group with longer CPB time.</p>}},
  author       = {{Dardashti, Alain and Sterner, Niklas and Fisher, Jane and Thelaus, Louise and Nilsson, Johan and Linder, Adam and Zindovic, Igor}},
  issn         = {{0036-5513}},
  keywords     = {{Cardiac surgery; cardiopulmonary bypass; prognosis; receptors; urokinase plasminogen activator}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{634--640}},
  publisher    = {{Informa Healthcare}},
  series       = {{Scandinavian Journal of Clinical and Laboratory Investigation}},
  title        = {{Impact of cardiopulmonary bypass and surgical complexity on plasma soluble urokinase-type plasminogen activator receptor levels after cardiac surgery}},
  url          = {{http://dx.doi.org/10.1080/00365513.2021.1990395}},
  doi          = {{10.1080/00365513.2021.1990395}},
  volume       = {{81}},
  year         = {{2021}},
}