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Different HLA-DR-DQ haplotypes are associated with cervical intraepithelial neoplasia among human papillomavirus type-16 seropositive and seronegative Swedish women

Sanjeei, C. B. ; Hjelmström, P. ; Hallmans, G. ; Wiklund, F. ; Lenner, P. ; Ångström, T. ; Dillner, J. LU and Lernmark, Å LU (1996) In International Journal of Cancer 68(4). p.409-414
Abstract

To analyze whether HLA may be a determinant of the risk of developing cervical cancer precursor lesions, the association between HLA and cervical neoplasia among HPV16-seropositive and -negative subjects was determined in a population-based cohort in the Vasterbotten county of Northern Sweden. HLA genotyping of DR and DQ was done by PCR in 74 patients and 164 healthy controls matched for age, sex and area of residence. The presence of DQA1*0102 was weakly associated with cervical neoplasia in HPV16-seropositive patients. DQB1*0602 was weakly associated with disease in all patients, but was strongly increased among HPV16-seropositive patients compared to HPV16-seropositive controls. DR15 had an association with disease that was... (More)

To analyze whether HLA may be a determinant of the risk of developing cervical cancer precursor lesions, the association between HLA and cervical neoplasia among HPV16-seropositive and -negative subjects was determined in a population-based cohort in the Vasterbotten county of Northern Sweden. HLA genotyping of DR and DQ was done by PCR in 74 patients and 164 healthy controls matched for age, sex and area of residence. The presence of DQA1*0102 was weakly associated with cervical neoplasia in HPV16-seropositive patients. DQB1*0602 was weakly associated with disease in all patients, but was strongly increased among HPV16-seropositive patients compared to HPV16-seropositive controls. DR15 had an association with disease that was particularly strong among HPV16-seropositive subjects. The haplotype DQA1*0102-DQB1*0602 (DQ6) was also weakly associated with disease in all patients and significantly increased among HPV16-positive patients when compared to HPV16-positive controls. A similar association was seen when analysis was restricted to CIN 2-3 patients. DQA1*0501-DQB1*0301 (DQ7) was more common among HPV16-negative patients than among HPV16-negative controls and was also more common among HPV16-negative patients than among HPV16-positive patients. In conclusion, DQA1*0102-DQB1*0602 (DQ6) is associated with an increased risk of cervical neoplasia among HPV16-seropositive subjects and DQA1*0501-DQB1*0301 (DQ7) with an increased risk among HPV16-seronegative subjects.

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author
; ; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
in
International Journal of Cancer
volume
68
issue
4
pages
409 - 414
publisher
John Wiley and Sons Inc.
external identifiers
  • scopus:0029807161
  • pmid:8945607
ISSN
0020-7136
DOI
10.1002/(SICI)1097-0215(19961115)68:4<409::AID-IJC1>3.3.CO;2-P
language
English
LU publication?
no
id
8a5117d3-ce71-4b95-be80-1becebdb471f
date added to LUP
2019-07-01 13:25:46
date last changed
2020-07-01 05:15:48
@article{8a5117d3-ce71-4b95-be80-1becebdb471f,
  abstract     = {<p>To analyze whether HLA may be a determinant of the risk of developing cervical cancer precursor lesions, the association between HLA and cervical neoplasia among HPV16-seropositive and -negative subjects was determined in a population-based cohort in the Vasterbotten county of Northern Sweden. HLA genotyping of DR and DQ was done by PCR in 74 patients and 164 healthy controls matched for age, sex and area of residence. The presence of DQA1*0102 was weakly associated with cervical neoplasia in HPV16-seropositive patients. DQB1*0602 was weakly associated with disease in all patients, but was strongly increased among HPV16-seropositive patients compared to HPV16-seropositive controls. DR15 had an association with disease that was particularly strong among HPV16-seropositive subjects. The haplotype DQA1*0102-DQB1*0602 (DQ6) was also weakly associated with disease in all patients and significantly increased among HPV16-positive patients when compared to HPV16-positive controls. A similar association was seen when analysis was restricted to CIN 2-3 patients. DQA1*0501-DQB1*0301 (DQ7) was more common among HPV16-negative patients than among HPV16-negative controls and was also more common among HPV16-negative patients than among HPV16-positive patients. In conclusion, DQA1*0102-DQB1*0602 (DQ6) is associated with an increased risk of cervical neoplasia among HPV16-seropositive subjects and DQA1*0501-DQB1*0301 (DQ7) with an increased risk among HPV16-seronegative subjects.</p>},
  author       = {Sanjeei, C. B. and Hjelmström, P. and Hallmans, G. and Wiklund, F. and Lenner, P. and Ångström, T. and Dillner, J. and Lernmark, Å},
  issn         = {0020-7136},
  language     = {eng},
  month        = {12},
  number       = {4},
  pages        = {409--414},
  publisher    = {John Wiley and Sons Inc.},
  series       = {International Journal of Cancer},
  title        = {Different HLA-DR-DQ haplotypes are associated with cervical intraepithelial neoplasia among human papillomavirus type-16 seropositive and seronegative Swedish women},
  url          = {http://dx.doi.org/10.1002/(SICI)1097-0215(19961115)68:4<409::AID-IJC1>3.3.CO;2-P},
  doi          = {10.1002/(SICI)1097-0215(19961115)68:4<409::AID-IJC1>3.3.CO;2-P},
  volume       = {68},
  year         = {1996},
}