Cutting Edge : Lymphomyeloid-Primed Progenitor Cell Fates Are Controlled by the Transcription Factor Tal1
(2019) In Journal of immunology 202(10). p.2837-2842- Abstract
Lymphoid specification is the process by which hematopoietic stem cells (HSCs) and their progeny become restricted to differentiation through the lymphoid lineages. The basic helix-loop-helix transcription factors E2A and Lyl1 form a complex that promotes lymphoid specification. In this study, we demonstrate that Tal1, a Lyl1-related basic helix-loop-helix transcription factor that promotes T acute lymphoblastic leukemia and is required for HSC specification, erythropoiesis, and megakaryopoiesis, is a negative regulator of murine lymphoid specification. We demonstrate that Tal1 limits the expression of multiple E2A target genes in HSCs and controls the balance of myeloid versus T lymphocyte differentiation potential in... (More)
Lymphoid specification is the process by which hematopoietic stem cells (HSCs) and their progeny become restricted to differentiation through the lymphoid lineages. The basic helix-loop-helix transcription factors E2A and Lyl1 form a complex that promotes lymphoid specification. In this study, we demonstrate that Tal1, a Lyl1-related basic helix-loop-helix transcription factor that promotes T acute lymphoblastic leukemia and is required for HSC specification, erythropoiesis, and megakaryopoiesis, is a negative regulator of murine lymphoid specification. We demonstrate that Tal1 limits the expression of multiple E2A target genes in HSCs and controls the balance of myeloid versus T lymphocyte differentiation potential in lymphomyeloid-primed progenitors. Our data provide insight into the mechanisms controlling lymphocyte specification and may reveal a basis for the unique functions of Tal1 and Lyl1 in T acute lymphoblastic leukemia.
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- author
- de Pooter, Renée F. ; Dias, Sheila ; Chowdhury, Munmun ; Bartom, Elisabeth T. ; Okoreeh, Michael K. ; Sigvardsson, Mikael LU and Kee, Barbara L.
- organization
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of immunology
- volume
- 202
- issue
- 10
- pages
- 6 pages
- publisher
- American Association of Immunologists
- external identifiers
-
- pmid:30962294
- scopus:85065678622
- ISSN
- 1550-6606
- DOI
- 10.4049/jimmunol.1801220
- language
- English
- LU publication?
- yes
- id
- 8a6aff71-e140-4efe-96d6-363230f32711
- date added to LUP
- 2019-05-28 10:22:48
- date last changed
- 2024-09-17 23:42:33
@article{8a6aff71-e140-4efe-96d6-363230f32711, abstract = {{<p>Lymphoid specification is the process by which hematopoietic stem cells (HSCs) and their progeny become restricted to differentiation through the lymphoid lineages. The basic helix-loop-helix transcription factors E2A and Lyl1 form a complex that promotes lymphoid specification. In this study, we demonstrate that Tal1, a Lyl1-related basic helix-loop-helix transcription factor that promotes T acute lymphoblastic leukemia and is required for HSC specification, erythropoiesis, and megakaryopoiesis, is a negative regulator of murine lymphoid specification. We demonstrate that Tal1 limits the expression of multiple E2A target genes in HSCs and controls the balance of myeloid versus T lymphocyte differentiation potential in lymphomyeloid-primed progenitors. Our data provide insight into the mechanisms controlling lymphocyte specification and may reveal a basis for the unique functions of Tal1 and Lyl1 in T acute lymphoblastic leukemia.</p>}}, author = {{de Pooter, Renée F. and Dias, Sheila and Chowdhury, Munmun and Bartom, Elisabeth T. and Okoreeh, Michael K. and Sigvardsson, Mikael and Kee, Barbara L.}}, issn = {{1550-6606}}, language = {{eng}}, number = {{10}}, pages = {{2837--2842}}, publisher = {{American Association of Immunologists}}, series = {{Journal of immunology}}, title = {{Cutting Edge : Lymphomyeloid-Primed Progenitor Cell Fates Are Controlled by the Transcription Factor Tal1}}, url = {{http://dx.doi.org/10.4049/jimmunol.1801220}}, doi = {{10.4049/jimmunol.1801220}}, volume = {{202}}, year = {{2019}}, }