Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Serum amyloid P component : A new biomarker for low sperm concentration?

Sonesson, Annika LU ; Malm, Johan LU ; Rylander, Lars LU orcid ; Giwercman, Aleksander LU and Hillarp, Andreas LU (2021) In Asian Journal of Andrology 23(5). p.450-455
Abstract

Serum amyloid P component (SAP) is present in seminal plasma, on spermatozoa, and in different tissues of the male reproductive tract, but its function is not known. The aims of this study were to determine if the concentration of SAP in seminal plasma is associated with commonly assessed semen parameters and to investigate if SAP could be a new, indirect biomarker for these parameters. In a cross-sectional study of 203 young volunteers, the concentration of SAP in seminal plasma was measured with a in-house developed enzyme-linked immunosorbent assay. Scatter plots, Pearson's correlation coefficients (r), and linear regression models were produced, and SAP showed a statistically significant correlation with sperm concentration (r =... (More)

Serum amyloid P component (SAP) is present in seminal plasma, on spermatozoa, and in different tissues of the male reproductive tract, but its function is not known. The aims of this study were to determine if the concentration of SAP in seminal plasma is associated with commonly assessed semen parameters and to investigate if SAP could be a new, indirect biomarker for these parameters. In a cross-sectional study of 203 young volunteers, the concentration of SAP in seminal plasma was measured with a in-house developed enzyme-linked immunosorbent assay. Scatter plots, Pearson's correlation coefficients (r), and linear regression models were produced, and SAP showed a statistically significant correlation with sperm concentration (r = 0.75), sperm number (r = 0.68), semen volume (r =-0.19), progressive sperm motility (r = 0.24), and sperm immotility (r =-0.20). When the study group was dichotomized, SAP could be used to discriminate samples with a sperm concentration or =5 × 106 ml-1, 15 × 106 ml-1, or 40 × 106 ml-1, and in receiver operating characteristic curves, the corresponding areas under the curves were 0.97, 0.93, and 0.82, respectively, with P 0.001 for all three cutoff values studied. The concentration of SAP in seminal plasma showed a strong, positive correlation with the concentration of spermatozoa in semen. SAP may be used as a new indirect potential biomarker for sperm concentration in fresh and in frozen, stored samples. In addition, it is envisaged that the assay could be developed into a home fertility test to differentiate between a low and a normal sperm concentration.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Fertility, Reproduction, Seminal plasma, Serum amyloid p component, Sperm
in
Asian Journal of Andrology
volume
23
issue
5
pages
6 pages
publisher
Wolters Kluwer
external identifiers
  • scopus:85114445815
  • pmid:33723096
ISSN
1008-682X
DOI
10.4103/aja.aja_7_21
language
English
LU publication?
yes
id
8a82801d-0314-435a-a1ec-d4aa8f92d6bf
date added to LUP
2021-10-07 12:35:51
date last changed
2025-01-13 14:41:03
@article{8a82801d-0314-435a-a1ec-d4aa8f92d6bf,
  abstract     = {{<p>Serum amyloid P component (SAP) is present in seminal plasma, on spermatozoa, and in different tissues of the male reproductive tract, but its function is not known. The aims of this study were to determine if the concentration of SAP in seminal plasma is associated with commonly assessed semen parameters and to investigate if SAP could be a new, indirect biomarker for these parameters. In a cross-sectional study of 203 young volunteers, the concentration of SAP in seminal plasma was measured with a in-house developed enzyme-linked immunosorbent assay. Scatter plots, Pearson's correlation coefficients (r), and linear regression models were produced, and SAP showed a statistically significant correlation with sperm concentration (r = 0.75), sperm number (r = 0.68), semen volume (r =-0.19), progressive sperm motility (r = 0.24), and sperm immotility (r =-0.20). When the study group was dichotomized, SAP could be used to discriminate samples with a sperm concentration or =5 × 106 ml-1, 15 × 106 ml-1, or 40 × 106 ml-1, and in receiver operating characteristic curves, the corresponding areas under the curves were 0.97, 0.93, and 0.82, respectively, with P 0.001 for all three cutoff values studied. The concentration of SAP in seminal plasma showed a strong, positive correlation with the concentration of spermatozoa in semen. SAP may be used as a new indirect potential biomarker for sperm concentration in fresh and in frozen, stored samples. In addition, it is envisaged that the assay could be developed into a home fertility test to differentiate between a low and a normal sperm concentration.</p>}},
  author       = {{Sonesson, Annika and Malm, Johan and Rylander, Lars and Giwercman, Aleksander and Hillarp, Andreas}},
  issn         = {{1008-682X}},
  keywords     = {{Fertility; Reproduction; Seminal plasma; Serum amyloid p component; Sperm}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{450--455}},
  publisher    = {{Wolters Kluwer}},
  series       = {{Asian Journal of Andrology}},
  title        = {{Serum amyloid P component : A new biomarker for low sperm concentration?}},
  url          = {{http://dx.doi.org/10.4103/aja.aja_7_21}},
  doi          = {{10.4103/aja.aja_7_21}},
  volume       = {{23}},
  year         = {{2021}},
}