Advanced

Epidemiology of Kaposi's sarcoma herpesvirus (HHV8) in Vasterbotten county, Sweden

Tedeschi, R ; Bidoli, E ; Agren, A ; Hallmans, G ; Wadell, G ; De Paoli, P and Dillner, Joakim LU (2006) In Journal of Medical Virology 78(3). p.372-378
Abstract
A population-based serosurvey of Human Herpesvirus type 8 (HHV8) in Vasterbotten county, an area of Northern Sweden with high incidence of Kaposi's Sarcoma, was conducted. Serum samples from an age- and sex-stratified random sample of 520 subjects (260 men and 260 women) participating in a population-based biobanking project were tested for antibodies against HHV8, using a sensitive indirect immunofluorescence assay to latent and lytic HHV8 antigens. Buffy coat DNA was also analyzed for viral DNA using real time PCR assay. HHV8 DNA was not detectable in any one of the buffy coat samples. Eighty-four subjects (16.2%) were HHV8 seropositive, 14.4% for the lytic HHV8 antigen, and 1.7% for the latent HHV8 antigen. HHV8 seroprevalences were not... (More)
A population-based serosurvey of Human Herpesvirus type 8 (HHV8) in Vasterbotten county, an area of Northern Sweden with high incidence of Kaposi's Sarcoma, was conducted. Serum samples from an age- and sex-stratified random sample of 520 subjects (260 men and 260 women) participating in a population-based biobanking project were tested for antibodies against HHV8, using a sensitive indirect immunofluorescence assay to latent and lytic HHV8 antigens. Buffy coat DNA was also analyzed for viral DNA using real time PCR assay. HHV8 DNA was not detectable in any one of the buffy coat samples. Eighty-four subjects (16.2%) were HHV8 seropositive, 14.4% for the lytic HHV8 antigen, and 1.7% for the latent HHV8 antigen. HHV8 seroprevalences were not associated significantly with sex or age. HHV8 seropositivity was more common among smokers (OR: 1.95, 95% CI: 1.02-3.75), but was less common among consumers of wine and spirits (OR: 0.44,95% CI: 0.25-0.77 and OR: 0.50,95% CI: 0.26-0.95, respectively). In summary, HHV8 has an intermediate high and stable seroprevalence rate in Northern Sweden, but environmental determinants that can explain the viral distribution were not found. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
biobank, population-based study, seroprevalence, IFA, antibody, HHV8
in
Journal of Medical Virology
volume
78
issue
3
pages
372 - 378
publisher
John Wiley & Sons
external identifiers
  • pmid:16419115
  • wos:000235202300010
  • scopus:33644646896
ISSN
1096-9071
DOI
10.1002/jmv.20549
language
English
LU publication?
yes
id
8ac0133a-ae03-4eea-b826-a992f703f7b2 (old id 417743)
date added to LUP
2016-04-01 12:13:59
date last changed
2019-11-26 03:25:28
@article{8ac0133a-ae03-4eea-b826-a992f703f7b2,
  abstract     = {A population-based serosurvey of Human Herpesvirus type 8 (HHV8) in Vasterbotten county, an area of Northern Sweden with high incidence of Kaposi's Sarcoma, was conducted. Serum samples from an age- and sex-stratified random sample of 520 subjects (260 men and 260 women) participating in a population-based biobanking project were tested for antibodies against HHV8, using a sensitive indirect immunofluorescence assay to latent and lytic HHV8 antigens. Buffy coat DNA was also analyzed for viral DNA using real time PCR assay. HHV8 DNA was not detectable in any one of the buffy coat samples. Eighty-four subjects (16.2%) were HHV8 seropositive, 14.4% for the lytic HHV8 antigen, and 1.7% for the latent HHV8 antigen. HHV8 seroprevalences were not associated significantly with sex or age. HHV8 seropositivity was more common among smokers (OR: 1.95, 95% CI: 1.02-3.75), but was less common among consumers of wine and spirits (OR: 0.44,95% CI: 0.25-0.77 and OR: 0.50,95% CI: 0.26-0.95, respectively). In summary, HHV8 has an intermediate high and stable seroprevalence rate in Northern Sweden, but environmental determinants that can explain the viral distribution were not found.},
  author       = {Tedeschi, R and Bidoli, E and Agren, A and Hallmans, G and Wadell, G and De Paoli, P and Dillner, Joakim},
  issn         = {1096-9071},
  language     = {eng},
  number       = {3},
  pages        = {372--378},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Medical Virology},
  title        = {Epidemiology of Kaposi's sarcoma herpesvirus (HHV8) in Vasterbotten county, Sweden},
  url          = {http://dx.doi.org/10.1002/jmv.20549},
  doi          = {10.1002/jmv.20549},
  volume       = {78},
  year         = {2006},
}