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Circulating high sensitivity C reactive protein concentrations and risk of lung cancer : Nested case-control study within Lung Cancer Cohort Consortium

Muller, David C. ; Larose, Tricia L. ; Hodge, Allison ; Guida, Florence ; Langhammer, Arnulf ; Grankvist, Kjell ; Meyer, Klaus ; Cai, Qiuyin ; Arslan, Alan A. and Zeleniuch-Jacquotte, Anne , et al. (2019) In BMJ (Online) 364.
Abstract

Objectives To conduct a comprehensive analysis of prospectively measured circulating high sensitivity C reactive protein (hsCRP) concentration and risk of lung cancer overall, by smoking status (never, former, and current smokers), and histological sub-type. Design Nested case-control study. setting 20 population based cohort studies in Asia, Europe, Australia, and the United States. ParticiPants 5299 patients with incident lung cancer, with individually incidence density matched controls. exPOsure Circulating hsCRP concentrations in prediagnostic serum or plasma samples. Main OutcOMe Measure Incident lung cancer diagnosis. results A positive association between circulating hsCRP concentration and the risk of lung cancer for current... (More)

Objectives To conduct a comprehensive analysis of prospectively measured circulating high sensitivity C reactive protein (hsCRP) concentration and risk of lung cancer overall, by smoking status (never, former, and current smokers), and histological sub-type. Design Nested case-control study. setting 20 population based cohort studies in Asia, Europe, Australia, and the United States. ParticiPants 5299 patients with incident lung cancer, with individually incidence density matched controls. exPOsure Circulating hsCRP concentrations in prediagnostic serum or plasma samples. Main OutcOMe Measure Incident lung cancer diagnosis. results A positive association between circulating hsCRP concentration and the risk of lung cancer for current (odds ratio associated with a doubling in hsCRP concentration 1.09, 95% confidence interval 1.05 to 1.13) and former smokers (1.09, 1.04 to 1.14) was observed, but not for never smokers (P<0.01 for interaction). This association was strong and consistent across all histological subtypes, except for adenocarcinoma, which was not strongly associated with hsCRP concentration regardless of smoking status (odds ratio for adenocarcinoma overall 0.97, 95% confidence interval 0.94 to 1.01). The association between circulating hsCRP concentration and the risk of lung cancer was strongest in the first two years of follow-up for former and current smokers. Including hsCRP concentration in a risk model, in addition to smoking based variables, did not improve risk discrimination overall, but slightly improved discrimination for cancers diagnosed in the first two years of follow-up. cOnclusiOns Former and current smokers with higher circulating hsCRP concentrations had a higher risk of lung cancer overall. Circulating hsCRP concentration was not associated with the risk of lung adenocarcinoma. Circulating hsCRP concentration could be a prediagnostic marker of lung cancer rather than a causal risk factor.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
BMJ (Online)
volume
364
article number
k4981
publisher
BMJ Publishing Group
external identifiers
  • scopus:85059500268
  • pmid:30606716
ISSN
1756-1833
DOI
10.1136/bmj.k4981
language
English
LU publication?
yes
id
8ae20080-d8b7-4f35-aeaa-6212fbaeb6b4
date added to LUP
2019-01-22 09:17:25
date last changed
2024-11-12 19:44:27
@article{8ae20080-d8b7-4f35-aeaa-6212fbaeb6b4,
  abstract     = {{<p>Objectives To conduct a comprehensive analysis of prospectively measured circulating high sensitivity C reactive protein (hsCRP) concentration and risk of lung cancer overall, by smoking status (never, former, and current smokers), and histological sub-type. Design Nested case-control study. setting 20 population based cohort studies in Asia, Europe, Australia, and the United States. ParticiPants 5299 patients with incident lung cancer, with individually incidence density matched controls. exPOsure Circulating hsCRP concentrations in prediagnostic serum or plasma samples. Main OutcOMe Measure Incident lung cancer diagnosis. results A positive association between circulating hsCRP concentration and the risk of lung cancer for current (odds ratio associated with a doubling in hsCRP concentration 1.09, 95% confidence interval 1.05 to 1.13) and former smokers (1.09, 1.04 to 1.14) was observed, but not for never smokers (P&lt;0.01 for interaction). This association was strong and consistent across all histological subtypes, except for adenocarcinoma, which was not strongly associated with hsCRP concentration regardless of smoking status (odds ratio for adenocarcinoma overall 0.97, 95% confidence interval 0.94 to 1.01). The association between circulating hsCRP concentration and the risk of lung cancer was strongest in the first two years of follow-up for former and current smokers. Including hsCRP concentration in a risk model, in addition to smoking based variables, did not improve risk discrimination overall, but slightly improved discrimination for cancers diagnosed in the first two years of follow-up. cOnclusiOns Former and current smokers with higher circulating hsCRP concentrations had a higher risk of lung cancer overall. Circulating hsCRP concentration was not associated with the risk of lung adenocarcinoma. Circulating hsCRP concentration could be a prediagnostic marker of lung cancer rather than a causal risk factor.</p>}},
  author       = {{Muller, David C. and Larose, Tricia L. and Hodge, Allison and Guida, Florence and Langhammer, Arnulf and Grankvist, Kjell and Meyer, Klaus and Cai, Qiuyin and Arslan, Alan A. and Zeleniuch-Jacquotte, Anne and Albanes, Demetrius and Giles, Graham G. and Sesso, Howard D. and Lee, I. Min and Gaziano, J. Michael and Yuan, Jian Min and Bolton, Judith Hoffman and Buring, Julie E. and Visvanathan, Kala and Le Marchand, Loic and Purdue, Mark P. and Caporaso, Neil E. and Midttun, Øivind and Ueland, Per M. and Prentice, Ross L. and Weinstein, Stephanie J. and Stevens, Victoria L. and Zheng, Wei and Blot, William J. and Shu, Xiao Ou and Zhang, Xuehong and Xiang, Yong Bing and Koh, Woon Puay and Hveem, Kristian and Thomson, Cynthia A. and Pettinger, Mary and Engström, Gunnar and Brunnström, Hans and Milne, Roger L. and Stampfer, Meir J. and Han, Jiali and Johansson, Mikael and Brennan, Paul and Severi, Gianluca and Johansson, Mattias}},
  issn         = {{1756-1833}},
  language     = {{eng}},
  publisher    = {{BMJ Publishing Group}},
  series       = {{BMJ (Online)}},
  title        = {{Circulating high sensitivity C reactive protein concentrations and risk of lung cancer : Nested case-control study within Lung Cancer Cohort Consortium}},
  url          = {{http://dx.doi.org/10.1136/bmj.k4981}},
  doi          = {{10.1136/bmj.k4981}},
  volume       = {{364}},
  year         = {{2019}},
}