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Impact of ABO blood group on bleeding complications after surgery for acute type A aortic dissection

Guné, Henrik LU orcid ; Larsson, Mårten LU ; Nozohoor, Shahab LU orcid ; Herou, Erik LU orcid ; Luts, Cecilia LU orcid ; Ragnarsson, Sigurdur LU ; Samuelsson, Maria ; Sjögren, Johan LU ; Svensson, Peter J. LU and Zindovic, Igor LU (2021) In Blood Coagulation and Fibrinolysis 32(4). p.253-258
Abstract

Excessive bleeding is a serious complication associated with impaired survival after surgery for acute type A aortic dissection (ATAAD). Different ABO blood groups are associated with variable levels of circulating von Willebrand factor and therefore potentially altered risks of surgical haemorrhage. The current study aimed to assess the impact of blood group on bleeding complications after ATAAD surgery. This was a retrospective cohort study including 336 patients surgically treated for ATAAD between January 2004 and January 2019. Patients with blood group O were compared with non-O patients. In total, 152 blood group O patients were compared with 184 non-O patients. There were no differences in rates of massive bleeding (27.0 vs.... (More)

Excessive bleeding is a serious complication associated with impaired survival after surgery for acute type A aortic dissection (ATAAD). Different ABO blood groups are associated with variable levels of circulating von Willebrand factor and therefore potentially altered risks of surgical haemorrhage. The current study aimed to assess the impact of blood group on bleeding complications after ATAAD surgery. This was a retrospective cohort study including 336 patients surgically treated for ATAAD between January 2004 and January 2019. Patients with blood group O were compared with non-O patients. In total, 152 blood group O patients were compared with 184 non-O patients. There were no differences in rates of massive bleeding (27.0 vs. 25.5%, P = 0.767) or re-exploration for bleeding (16.4 vs. 13.0%, P = 0.379) in blood group O and non-O patients, respectively. Median chest tube output 12 h after surgery was 520 ml (350-815 ml) in blood group O and 490 ml (278-703 ml) in non-O patients (P = 0.229). Blood group O patients received more fibrinogen concentrate (6.1 ± 4.0 vs. 4.9 ± 3.3 g, P = 0.023) but administered units of packed red blood cells [5 (2-8) vs. 4 (2-9) U, P = 0.736], platelets [4 (2-4) vs. 3 (2-5) U, P = 0.521] or plasma [4 (1-7) vs. 4 (0-7) U, P = 0.562] were similar. This study could not demonstrate any association between blood group and bleeding after surgery for ATAAD. It cannot be ruled out that potential differences were levelled out by blood group O patients receiving significantly more fibrinogen concentrate.

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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Blood Coagulation and Fibrinolysis
volume
32
issue
4
pages
253 - 258
publisher
Lippincott Williams & Wilkins
external identifiers
  • scopus:85105510376
  • pmid:33955859
ISSN
1473-5733
DOI
10.1097/MBC.0000000000001024
language
English
LU publication?
yes
id
8b27ca0c-6205-4ee7-bc33-ee96542c94b4
date added to LUP
2021-06-01 09:31:47
date last changed
2025-03-01 03:21:19
@article{8b27ca0c-6205-4ee7-bc33-ee96542c94b4,
  abstract     = {{<p>Excessive bleeding is a serious complication associated with impaired survival after surgery for acute type A aortic dissection (ATAAD). Different ABO blood groups are associated with variable levels of circulating von Willebrand factor and therefore potentially altered risks of surgical haemorrhage. The current study aimed to assess the impact of blood group on bleeding complications after ATAAD surgery. This was a retrospective cohort study including 336 patients surgically treated for ATAAD between January 2004 and January 2019. Patients with blood group O were compared with non-O patients. In total, 152 blood group O patients were compared with 184 non-O patients. There were no differences in rates of massive bleeding (27.0 vs. 25.5%, P = 0.767) or re-exploration for bleeding (16.4 vs. 13.0%, P = 0.379) in blood group O and non-O patients, respectively. Median chest tube output 12 h after surgery was 520 ml (350-815 ml) in blood group O and 490 ml (278-703 ml) in non-O patients (P = 0.229). Blood group O patients received more fibrinogen concentrate (6.1 ± 4.0 vs. 4.9 ± 3.3 g, P = 0.023) but administered units of packed red blood cells [5 (2-8) vs. 4 (2-9) U, P = 0.736], platelets [4 (2-4) vs. 3 (2-5) U, P = 0.521] or plasma [4 (1-7) vs. 4 (0-7) U, P = 0.562] were similar. This study could not demonstrate any association between blood group and bleeding after surgery for ATAAD. It cannot be ruled out that potential differences were levelled out by blood group O patients receiving significantly more fibrinogen concentrate.</p>}},
  author       = {{Guné, Henrik and Larsson, Mårten and Nozohoor, Shahab and Herou, Erik and Luts, Cecilia and Ragnarsson, Sigurdur and Samuelsson, Maria and Sjögren, Johan and Svensson, Peter J. and Zindovic, Igor}},
  issn         = {{1473-5733}},
  language     = {{eng}},
  month        = {{06}},
  number       = {{4}},
  pages        = {{253--258}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{Blood Coagulation and Fibrinolysis}},
  title        = {{Impact of ABO blood group on bleeding complications after surgery for acute type A aortic dissection}},
  url          = {{http://dx.doi.org/10.1097/MBC.0000000000001024}},
  doi          = {{10.1097/MBC.0000000000001024}},
  volume       = {{32}},
  year         = {{2021}},
}