Road Traffic Noise Exposure and Filled Prescriptions for Antihypertensive Medication : A Danish Cohort Study
(2020) In Environmental Health Perspectives 128(5). p.1-9- Abstract
BACKGROUND: Epidemiological research on effects of transportation noise on incident hypertension is inconsistent.
OBJECTIVES: We aimed to investigate whether residential road traffic noise increases the risk for hypertension.
METHODS: In a population-based cohort of 57,053 individuals 50-64 years of age at enrollment, we identified 21,241 individuals who fulfilled our case definition of filling ≥2 prescriptions and ≥180 defined daily doses of antihypertensive drugs (AHTs) within a year, during a mean follow-up time of 14.0 y. Residential addresses from 1987 to 2016 were obtained from national registers, and road traffic noise at the most exposed façade as well as the least exposed façade was modeled for all addresses.... (More)
BACKGROUND: Epidemiological research on effects of transportation noise on incident hypertension is inconsistent.
OBJECTIVES: We aimed to investigate whether residential road traffic noise increases the risk for hypertension.
METHODS: In a population-based cohort of 57,053 individuals 50-64 years of age at enrollment, we identified 21,241 individuals who fulfilled our case definition of filling ≥2 prescriptions and ≥180 defined daily doses of antihypertensive drugs (AHTs) within a year, during a mean follow-up time of 14.0 y. Residential addresses from 1987 to 2016 were obtained from national registers, and road traffic noise at the most exposed façade as well as the least exposed façade was modeled for all addresses. Analyses were conducted using Cox proportional hazards models.
RESULTS: We found no associations between the 10-y mean exposure to road traffic noise and filled prescriptions for AHTs, with incidence rate ratios (IRRs) of 0.999 [95% confidence intervals (CI): 0.980, 1.019)] per 10-dB increase in road traffic noise at the most exposed façade and of 1.001 (95% CI: 0.977, 1.026) at the least exposed façade. Interaction analyses suggested an association with road traffic noise at the least exposed façade among subpopulations of current smokers and obese individuals.
CONCLUSION: The present study does not support an association between road traffic noise and filled prescriptions for AHTs. https://doi.org/10.1289/EHP6273.
(Less)
- author
- publishing date
- 2020-05
- type
- Contribution to journal
- publication status
- published
- keywords
- Adult, Air Pollution/statistics & numerical data, Antihypertensive Agents/therapeutic use, Cohort Studies, Denmark/epidemiology, Environmental Exposure/statistics & numerical data, Female, Humans, Hypertension/epidemiology, Male, Middle Aged, Noise, Transportation/statistics & numerical data, Prescriptions/statistics & numerical data, Proportional Hazards Models
- in
- Environmental Health Perspectives
- volume
- 128
- issue
- 5
- article number
- 057004
- pages
- 1 - 9
- publisher
- National Institute of Environmental Health Sciences
- external identifiers
-
- scopus:85085158410
- pmid:32438890
- ISSN
- 1552-9924
- DOI
- 10.1289/EHP6273
- language
- English
- LU publication?
- no
- id
- 8b2ab52d-f545-4de1-a03f-8f7019fd1d1b
- date added to LUP
- 2023-05-08 10:51:56
- date last changed
- 2024-04-19 21:36:53
@article{8b2ab52d-f545-4de1-a03f-8f7019fd1d1b,
abstract = {{<p>BACKGROUND: Epidemiological research on effects of transportation noise on incident hypertension is inconsistent.</p><p>OBJECTIVES: We aimed to investigate whether residential road traffic noise increases the risk for hypertension.</p><p>METHODS: In a population-based cohort of 57,053 individuals 50-64 years of age at enrollment, we identified 21,241 individuals who fulfilled our case definition of filling ≥2 prescriptions and ≥180 defined daily doses of antihypertensive drugs (AHTs) within a year, during a mean follow-up time of 14.0 y. Residential addresses from 1987 to 2016 were obtained from national registers, and road traffic noise at the most exposed façade as well as the least exposed façade was modeled for all addresses. Analyses were conducted using Cox proportional hazards models.</p><p>RESULTS: We found no associations between the 10-y mean exposure to road traffic noise and filled prescriptions for AHTs, with incidence rate ratios (IRRs) of 0.999 [95% confidence intervals (CI): 0.980, 1.019)] per 10-dB increase in road traffic noise at the most exposed façade and of 1.001 (95% CI: 0.977, 1.026) at the least exposed façade. Interaction analyses suggested an association with road traffic noise at the least exposed façade among subpopulations of current smokers and obese individuals.</p><p>CONCLUSION: The present study does not support an association between road traffic noise and filled prescriptions for AHTs. https://doi.org/10.1289/EHP6273.</p>}},
author = {{Thacher, Jesse D and Poulsen, Aslak H and Roswall, Nina and Hvidtfeldt, Ulla and Raaschou-Nielsen, Ole and Jensen, Steen Solvang and Ketzel, Matthias and Brandt, Jørgen and Overvad, Kim and Tjønneland, Anne and Münzel, Thomas and Sørensen, Mette}},
issn = {{1552-9924}},
keywords = {{Adult; Air Pollution/statistics & numerical data; Antihypertensive Agents/therapeutic use; Cohort Studies; Denmark/epidemiology; Environmental Exposure/statistics & numerical data; Female; Humans; Hypertension/epidemiology; Male; Middle Aged; Noise, Transportation/statistics & numerical data; Prescriptions/statistics & numerical data; Proportional Hazards Models}},
language = {{eng}},
number = {{5}},
pages = {{1--9}},
publisher = {{National Institute of Environmental Health Sciences}},
series = {{Environmental Health Perspectives}},
title = {{Road Traffic Noise Exposure and Filled Prescriptions for Antihypertensive Medication : A Danish Cohort Study}},
url = {{http://dx.doi.org/10.1289/EHP6273}},
doi = {{10.1289/EHP6273}},
volume = {{128}},
year = {{2020}},
}