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Cell density dependent release of hepatic lipase in cultured hepatocytes

Jensen, Elmo ; Florén, Claes-Henrik LU ; Hansson, Per ; Nilsson-Ehle, Peter LU and Nilsson, Åke LU (1989) In Hormone and Metabolic Research 21(1). p.4-7
Abstract
Cultured rat hepatocytes release the enzyme hepatic lipase. In this study we investigated the effect of cell density on this metabolic function under a variety of experimental conditions. The release of hepatic lipase from cultured rat hepatocytes exhibits a cell-density dependence, the secretion per mg cell protein being increased with increasing cell density. When cell density dependence was taken into consideration no significant effect of insulin on the release of hepatic lipase from cultured hepatocytes was observed, whereas glucagon suppressed the release. Glucose stimulating the release of the enzyme, especially in cultures with high cell density.
Please use this url to cite or link to this publication:
author
; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
in
Hormone and Metabolic Research
volume
21
issue
1
pages
4 pages
publisher
Georg Thieme Verlag
external identifiers
  • pmid:2647607
  • scopus:0024596519
ISSN
1439-4286
DOI
10.1055/s-2007-1009136
language
English
LU publication?
no
id
8bd92e94-6259-4862-9ddf-e32da52f0cbd
date added to LUP
2019-05-30 16:33:36
date last changed
2021-12-07 04:00:33
@article{8bd92e94-6259-4862-9ddf-e32da52f0cbd,
  abstract     = {{Cultured rat hepatocytes release the enzyme hepatic lipase. In this study we investigated the effect of cell density on this metabolic function under a variety of experimental conditions. The release of hepatic lipase from cultured rat hepatocytes exhibits a cell-density dependence, the secretion per mg cell protein being increased with increasing cell density. When cell density dependence was taken into consideration no significant effect of insulin on the release of hepatic lipase from cultured hepatocytes was observed, whereas glucagon suppressed the release. Glucose stimulating the release of the enzyme, especially in cultures with high cell density.}},
  author       = {{Jensen, Elmo and Florén, Claes-Henrik and Hansson, Per and Nilsson-Ehle, Peter and Nilsson, Åke}},
  issn         = {{1439-4286}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{1}},
  pages        = {{4--7}},
  publisher    = {{Georg Thieme Verlag}},
  series       = {{Hormone and Metabolic Research}},
  title        = {{Cell density dependent release of hepatic lipase in cultured hepatocytes}},
  url          = {{http://dx.doi.org/10.1055/s-2007-1009136}},
  doi          = {{10.1055/s-2007-1009136}},
  volume       = {{21}},
  year         = {{1989}},
}