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A set-up for respiratory tract deposition efficiency measurements (15–5000 nm) and first results for a group of children and adults

Rissler, Jenny LU ; Nicklasson, Hanna LU ; Gudmundsson, Anders LU ; Wollmer, Per LU ; Swietlicki, Erik LU and Löndahl, Jakob LU (2017) In Aerosol and Air Quality Research 17(5). p.1244-1255
Abstract

Exposure to airborne particulate matter is associated with a number of negative health effects ranging from respiratory diseases to systemic effects and cancer. One important factor for understanding the health effects is the individual variation in the respiratory tract deposition of inhaled particles. In this study, we describe an experimental set-up for size-resolved measurements of the lung deposited fraction of airborne particles, covering the diameter range from 15 to 5000 nm. The set-up includes a system for generating a stable aerosol with a sufficiently broad size distribution. We used a scanning mobility particle sizer and an aerodynamic particle sizer to determine particle number and size. The set-up was used to investigate... (More)

Exposure to airborne particulate matter is associated with a number of negative health effects ranging from respiratory diseases to systemic effects and cancer. One important factor for understanding the health effects is the individual variation in the respiratory tract deposition of inhaled particles. In this study, we describe an experimental set-up for size-resolved measurements of the lung deposited fraction of airborne particles, covering the diameter range from 15 to 5000 nm. The set-up includes a system for generating a stable aerosol with a sufficiently broad size distribution. We used a scanning mobility particle sizer and an aerodynamic particle sizer to determine particle number and size. The set-up was used to investigate individual differences in the deposition fraction (DF) of particles in the respiratory tract for a group of 67 subjects of both sexes aged 7–70 years. The measured DF was applied to two model aerosols, one representing an urban environment and one a rural environment, and the particle deposition rates were derived (i.e., the deposited amount of particles per unit time). Furthermore, the deposition rates were normalized to lung surface area and body mass – two dose measures that are considered relevant for the health effects of airborne particles. In addition to validation of the set-up, we show that there is a large individual variation in DF, with some subjects having a DF that is more than twice as high as that of others. Although we observe differences in the DF between different subgroups, most individual variation was explained neither by age nor by gender. When normalizing the deposition rates to lung surface area or body mass, the deposition rates of children become significantly higher than those of adults. Furthermore, the individual variability is larger for the lung surface area or body mass normalized deposition rates than for DF.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Aerosols, Airborne particles, Deposition efficiency, Dose rate, Individual variability
in
Aerosol and Air Quality Research
volume
17
issue
5
pages
12 pages
publisher
Taiwan Association for Aerosol Research
external identifiers
  • scopus:85018422203
  • wos:000403503700012
ISSN
1680-8584
DOI
10.4209/aaqr.2016.09.0425
language
English
LU publication?
yes
id
8cbaef5f-d03b-4918-8bf5-530fd35aa25c
date added to LUP
2017-05-17 14:13:38
date last changed
2017-09-18 11:36:05
@article{8cbaef5f-d03b-4918-8bf5-530fd35aa25c,
  abstract     = {<p>Exposure to airborne particulate matter is associated with a number of negative health effects ranging from respiratory diseases to systemic effects and cancer. One important factor for understanding the health effects is the individual variation in the respiratory tract deposition of inhaled particles. In this study, we describe an experimental set-up for size-resolved measurements of the lung deposited fraction of airborne particles, covering the diameter range from 15 to 5000 nm. The set-up includes a system for generating a stable aerosol with a sufficiently broad size distribution. We used a scanning mobility particle sizer and an aerodynamic particle sizer to determine particle number and size. The set-up was used to investigate individual differences in the deposition fraction (DF) of particles in the respiratory tract for a group of 67 subjects of both sexes aged 7–70 years. The measured DF was applied to two model aerosols, one representing an urban environment and one a rural environment, and the particle deposition rates were derived (i.e., the deposited amount of particles per unit time). Furthermore, the deposition rates were normalized to lung surface area and body mass – two dose measures that are considered relevant for the health effects of airborne particles. In addition to validation of the set-up, we show that there is a large individual variation in DF, with some subjects having a DF that is more than twice as high as that of others. Although we observe differences in the DF between different subgroups, most individual variation was explained neither by age nor by gender. When normalizing the deposition rates to lung surface area or body mass, the deposition rates of children become significantly higher than those of adults. Furthermore, the individual variability is larger for the lung surface area or body mass normalized deposition rates than for DF.</p>},
  author       = {Rissler, Jenny and Nicklasson, Hanna and Gudmundsson, Anders and Wollmer, Per and Swietlicki, Erik and Löndahl, Jakob},
  issn         = {1680-8584},
  keyword      = {Aerosols,Airborne particles,Deposition efficiency,Dose rate,Individual variability},
  language     = {eng},
  month        = {05},
  number       = {5},
  pages        = {1244--1255},
  publisher    = {Taiwan Association for Aerosol Research},
  series       = {Aerosol and Air Quality Research},
  title        = {A set-up for respiratory tract deposition efficiency measurements (15–5000 nm) and first results for a group of children and adults},
  url          = {http://dx.doi.org/10.4209/aaqr.2016.09.0425},
  volume       = {17},
  year         = {2017},
}