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Tumor stiffness extends its grip on the metastatic microenvironment

Reid, Steven E. LU and Zanivan, Sara (2017) In Molecular and Cellular Oncology 4(6).
Abstract

The increased stiffness of a tumor triggers a multitude of responses that aid cancer cell dissemination. Stiffness-induced expression of CCN1 mediates autocrine signaling in the endothelium to upregulate N-Cadherin levels. This permits more stable interactions with cancer cells and increases their ability to spread into the circulation.

Please use this url to cite or link to this publication:
author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
blood vessels, cancer metastasis, CYR61/CCN1, proteomics, stiffness
in
Molecular and Cellular Oncology
volume
4
issue
6
article number
e1372866
publisher
Taylor & Francis
external identifiers
  • pmid:29209654
  • scopus:85050724127
ISSN
2372-3556
DOI
10.1080/23723556.2017.1372866
language
English
LU publication?
yes
id
8cbaf922-c3d1-4cad-be2e-a7f478fdddf9
date added to LUP
2018-08-28 13:02:21
date last changed
2024-02-14 00:30:49
@article{8cbaf922-c3d1-4cad-be2e-a7f478fdddf9,
  abstract     = {{<p>The increased stiffness of a tumor triggers a multitude of responses that aid cancer cell dissemination. Stiffness-induced expression of CCN1 mediates autocrine signaling in the endothelium to upregulate N-Cadherin levels. This permits more stable interactions with cancer cells and increases their ability to spread into the circulation.</p>}},
  author       = {{Reid, Steven E. and Zanivan, Sara}},
  issn         = {{2372-3556}},
  keywords     = {{blood vessels; cancer metastasis; CYR61/CCN1; proteomics; stiffness}},
  language     = {{eng}},
  month        = {{11}},
  number       = {{6}},
  publisher    = {{Taylor & Francis}},
  series       = {{Molecular and Cellular Oncology}},
  title        = {{Tumor stiffness extends its grip on the metastatic microenvironment}},
  url          = {{http://dx.doi.org/10.1080/23723556.2017.1372866}},
  doi          = {{10.1080/23723556.2017.1372866}},
  volume       = {{4}},
  year         = {{2017}},
}