Tumor stiffness extends its grip on the metastatic microenvironment
(2017) In Molecular and Cellular Oncology 4(6).- Abstract
The increased stiffness of a tumor triggers a multitude of responses that aid cancer cell dissemination. Stiffness-induced expression of CCN1 mediates autocrine signaling in the endothelium to upregulate N-Cadherin levels. This permits more stable interactions with cancer cells and increases their ability to spread into the circulation.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8cbaf922-c3d1-4cad-be2e-a7f478fdddf9
- author
- Reid, Steven E. LU and Zanivan, Sara
- organization
- publishing date
- 2017-11-02
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- blood vessels, cancer metastasis, CYR61/CCN1, proteomics, stiffness
- in
- Molecular and Cellular Oncology
- volume
- 4
- issue
- 6
- article number
- e1372866
- publisher
- Taylor & Francis
- external identifiers
-
- pmid:29209654
- scopus:85050724127
- ISSN
- 2372-3556
- DOI
- 10.1080/23723556.2017.1372866
- language
- English
- LU publication?
- yes
- id
- 8cbaf922-c3d1-4cad-be2e-a7f478fdddf9
- date added to LUP
- 2018-08-28 13:02:21
- date last changed
- 2025-01-08 13:40:44
@article{8cbaf922-c3d1-4cad-be2e-a7f478fdddf9,
abstract = {{<p>The increased stiffness of a tumor triggers a multitude of responses that aid cancer cell dissemination. Stiffness-induced expression of CCN1 mediates autocrine signaling in the endothelium to upregulate N-Cadherin levels. This permits more stable interactions with cancer cells and increases their ability to spread into the circulation.</p>}},
author = {{Reid, Steven E. and Zanivan, Sara}},
issn = {{2372-3556}},
keywords = {{blood vessels; cancer metastasis; CYR61/CCN1; proteomics; stiffness}},
language = {{eng}},
month = {{11}},
number = {{6}},
publisher = {{Taylor & Francis}},
series = {{Molecular and Cellular Oncology}},
title = {{Tumor stiffness extends its grip on the metastatic microenvironment}},
url = {{http://dx.doi.org/10.1080/23723556.2017.1372866}},
doi = {{10.1080/23723556.2017.1372866}},
volume = {{4}},
year = {{2017}},
}